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Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The epidemiological and clinical data suggest the influence of gastroesophageal reflux disease (GER) on the course of bronchial asthma (BA). Pathogenetic relationships of both diseases are still not clear. The most possible theory seems to be micro-aspirations of refluxing digestive contents leading to the development of bronchial inflammation. It is increasingly improved the benefits of treatment for gastroesophageal reflux on asthma course. Apart from advices referring proper diet and resting with semirecumbent position, the most effective method of treatment seems to be appropriately high dose of proton pump inhibitors. It is seamed that in some cases an important role in development of GER could play hypotention produced in mediastinum in patients with exacerbated course of asthma. It is suggested to connect treatment of both illnesses to benefit in clinical course of GER and BA as well.
Pol Merkur Lekarski 2006 Oct
PMID:[The influence of gastroesophageal reflux on the course and therapy of bronchial asthma]. 1720 65

It is increasingly suggested a connection between gastroesophageal reflux (GER) and bronchial asthma (BA). Coexistence of both these diseases is suggested by presence of asthmatics symptoms in non-atopic patients, difficult control and resistance of the specific treatment for asthma disease in some patients, worsening of respiratory symptoms in circumstances which favored GER. The purpose of the paper was presentation of the potential pathogenetic relationships between asthma and GER, their clinical manifestations and epidemiology in different age groups, and finally confirmation of the effectiveness of treatments for gastroesophageal reflux (especially using protonic pumps inhibitors) in terms of their benefit on asthma course, both in children as in adults.
Pol Merkur Lekarski 2006 Oct
PMID:[The connection between gastroesophageal reflux and airways inflammatory diseases]. 1720 81

Otitis media with effusion (OME) is one of the most often diagnosed diseases in the pre-school children. OME is defined as the presence of effusion behind the intact tympanic memebrane without symptoms of acute infection. Pathogenesis of OME is multifactorial and represents the interactions between environmental, social, anatomical and infectious factors and an allergy. Due to the hearing impairment accompanying this disease, effective prevention and treatment are necessary. This publication presents current knowledge concerning etiopathogenesis of OME taking into consideration the role of Eustachian tube, infectious factor, allergy, immunological factors, NO and gastroesophageal reflux disease. Recommended methods of treatment depending on the clinical condition and the age of children are also presented. The initiation of appropriate therapy is crucial because of the possibility of remote complications.
Otolaryngol Pol 2006
PMID:[Current opinions on pathogenesis and treatment of otitis media with effusion in children]. 1726 39

Tetany, which occurs in young women, poses common diagnostic problem. Two types of tetany are distinguished: one which is characterized by hypocalcemia and which rarely occurs (in person after strumectomy in the course of post-operational hypoparathyroidism) and latent one, which occurs more often. In the literature there is a lack of precise data concerned witch most probably results from its underestimation. Clinical symptoms which appear in latent tetany (normocalcemic) are related to the intracellular magnesium deficiency and increased respiratory drive. A noncharacteristic clinical picture and the lack of a pathognomonic symptom, cause that despite of the fearly common occurrence, the latent tetany is rarely recognized. In this paper the case of a 53 year old women has been described. The women had the symptoms of gastroesophageal reflux of asthma and depressive syndrome, witch masked the symptoms of the latent tetany.
Pneumonol Alergol Pol 2006
PMID:[Latent tetany masked by syndroms of bronchial asthma and depressive syndrome. Case report]. 1726 73

The case of a thirty year old woman patient with subglottic oedema lasting for two years and causing periodically recurrent laryngeal breathlessness has been described. Multispecialistic diagnostic procedure as well as the clinical course of the disease have been presented. The issue of the degree to which the Hashimoto disease or the gastroesophageal reflux disease may be the cause of the oedema has been discussed.
Otolaryngol Pol 2006
PMID:[The case of chronic subglottic oedema in a woman patient with hashimoto thyroiditis and gastroesophageal reflux disease]. 1735 79

Gastroesophageal reflux disease (GERD) is a common cause of chronic cough, heartburn, epigastric or retrosternal discomfort, chest pain and abdominal pain or esophagitis. Our patients with OSAS seldom manifest GERD symptoms. We suspected that obesity and high pressure in abdominal cavity may induce acid gastroesophageal reflux in these patients. The aim of the study was to test the hypothesis that obesity, cigarettes smoking or ventilatory and gas exchange abnormalities provoke GERD. We studied 21 consecutive patients with severe OSAS (mean AHI 44.9+/-23.8) before CPAP treatment, all without GERD clinical symptoms. Standard polysomnography, gastroscopy and 24-h oesophageal pH monitoring was performed. There were 6 females, 15 males, mean age 57+/-9 years, mean BMI 38+/-6 kg/m2. All patients presented with normal spirometric and gas exchange values (mean VC 3.64+/-1.23 1, 90% of normal, mean FEV1 2.61+/-0.95 1, 83% of normal, mean FEV1%VC 72%, mean PaO2 68.1+/-7.7 mmHg, mean PaCO2 40.8+/-5.8 mmHg, mean pH 7.42+/-0.02). GERD was diagnosed in 14 patients. Patients with GERD were younger, more often were cigarettes smokers (5/14). We did not fi nd statistically significant differences between severity of OSAS, BMI, ventilatory or gas exchange parameters and GERD.
Pneumonol Alergol Pol 2006
PMID:[Gastroesophageal reflux disease (GERD) in patients with obstructive sleep apnoea syndrome (OSAS)]. 1742 43

Proton pump inhibitors (PPI) are characterized by high effectiveness, selectivity and few adverse events. Development of PPI was an important issue in aspect of acid-related diseases treatment. Nowadays following PPI are available on the market: omeprazole, lansoprazole, pantoprazole, rabeprazole and esomeprazole. In children these drugs are the most frequently use in gastritis and duodenitis, ulcer disease with coexistence of Helicobacter pylori infection and gastroesophageal reflux disease. Pharmacokinetics of PPI is slightly different in children than in adults and so far there is a lack of randomised studies assessing the efficacy of PPI i developmental period medicine on numerous groups of patients. In our study literature review of PPI use in children and youth was presented.
Pol Merkur Lekarski 2007 Feb
PMID:[Proton pump inhibitors in developmental period medicine]. 1759 63

Tretament in gastro-esophageal reflux disease (GERD) is in constant change. It is caused by the fact of change and development of diagnostic and therapeutic methods. Alternative methods of treatment are still searched beacause patients do not accept many years long drug treatment or surgical procedures. New methods are developed. Some of them as endoscopic fundoplication or methods of polimerizing substances injection in the area of lower esophageal sphincer have been abandoned because of low quickly diminishing efficacy Endoscopic sewing that implicate all layers of gaster is still under clinical trials and is considered as interesting. Stertt's procedure that is based on electromagnetic wave application in the area of lower esophageal sphincter is used in clinical practice. Despite effective methods of diagnosing and treatment of GERD there is no evidence of lowering incidence of complications of GERD. It is still common to find esophagus stricture as the first illness manifastation. Chronic character of GERD is associated with intestinal metaplasia and adenocarcinoma of the esophagus in its distal part. The most effective endoscopic methods of the treatment include: endoscopic dilation of the strictures and endoscopic methods of patological epithelium removal in Barrett's esophagus. These are: photodynamic therapy, argon coagulation, laser thermoablation, multipolar ablation and endoscpic mucosectomy. The paper is the review of the methods aimed at GERD and its complication treatment.
Pol Merkur Lekarski 2007 May
PMID:[Endoscopic methods of gastro-esophageal reflux disease (GERD) treatment and their complications]. 1767 88

Gastroesophageal reflux is defined as regurgitation of the stomach contents into the esophagus due to transient or persistent failure of the lower esophageal sphincter. The measurement of impedance is a new technique used to diagnose gastroesophageal reflux. This technique is devoid of restrictions connected with classical esophageal pH-metry. Multichannel intraluminal impedance depends on changes in resistance to alternating current between two metal ring electrodes (impedance measuring segment) generated by the presence of bolus within that segment. The impedance measuring segments are located at 3, 5, 7, 9 cm (distal esophagus) and at 15 and 17 cm (proximal esophagus) over the proximal margin of the lower esophageal sphincter. The technique allows for classification of gastroesophageal reflux incidents as acid, weakly acidic and non-acid, assessment of reflux contents as liquid, gas or gas-liquid and the height of reflux regurgitation into the esophagus. The usefulness of pH-impedance analysis is still difficult due to the lack of normal values in children.
Pol Merkur Lekarski 2007 Oct
PMID:[Impedance-pH analysis in gastroesophageal reflux monitoring]. 1829 56

Helicobacter pylori is an etiologic factor of chronic gastritis, duodenal and gastric ulcers and gastric cancer or gastric MALT lymphoma. The role of H. pylori infection in gastroesophageal reflux disease (GERD) pathogenesis is still controversial. The presence of H. pylori infection in gastric mucosa may play a protective or aggressive role. It appears that the influence of H. pylori infection on frequency and degree of gastroesophageal reflux depends on the localization of inflammation. More active in inducing changes in mucosa are strains producing VacA and CagA cytotoxins. It has also been reported that CagA(+) strains protect more effectively against GERD and its complications. Not all results of studies confirm this dependence. Also, pathogenesis of the above dependences is not completely known. Treatment of the infection causes reduction in inflammatory changes and subsidence of symptoms, and it also reduces the risk of complications such as gastric and duodenal ulcers. The influence of H. pylori eradication on the degree of gastroesophageal reflux and the incidence of de novo GERD is undetermined.
Pol Merkur Lekarski 2007 Dec
PMID:[Influence of Helicobacter pylori on gastroesophageal reflux disease]. 1843 30


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