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Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Gastroesophageal reflux disease has become a serious problem not only for general practitioners but for other specialists as well. It is caused by the fact that its clinical picture and symptomatology are very rich. Beside characteristic symptoms such as: heartburn, eructation, gastric contents reflux, epigastric burning or dysphagia, there may appear extroesophageal symptoms (frequently as single or leading ones). It is generally though that the above symptoms result from the direct effect of gastric contents on throat and larynx and/or through vagus nerve. Direct effect of hydrochloric acid and other gastric juice components on larynx may be the cause of subglottic laryngostenosis, neoplastic transformation and development of squamous cell carcinoma. This, it may be concluded that gastroesophageal reflux disease should be in the sphere of interest of laryngologists as well as gastroenterologists. Cooperation of these specialists is particularly useful as it quickens the choice of proper diagnostic procedure and an introduction of an appropriate therapeutic treatment.
Otolaryngol Pol 2001
PMID:[Laryngeal mask of gastroesophageal reflux disease]. 1176 26

In the last few years the interest of extraesophageal symptoms of gastroesophageal reflux disease is getting greater and greater. Because of it is often appearance, this disease is noticed not only by gastroenterologists, but also other doctors and dentists. They think that pathological, backward reflux of esophagus in many cases can be responsible for dental organ disease. Clinical research proofs that often pouring the sour mixture from the stomach into the esophagus and then to mouth can cause a diminution in the teeth such as: erosion and decay. The background agum and tounque can be gastroesophageal reflux disease. acquantance with this facts among the dentists can help to make a diagnosis and treat well patients with a pathological reflux of esophagus.
Pol Merkur Lekarski 2002 Jan
PMID:[Dental mask of gastroesophageal reflux disease]. 1195 12

The aim of the current study was to analyse selected parameters of pH monitoring in the proximal and distal parts of esophagus. One hundred and twelve infants aged 1.25 to 18 months (mean = 5.6) with symptoms and signs suggesting gastroesophageal reflux (GER) were evaluated. The results are presented of the measurement of reflux index (RI), the number of reflux episodes and the duration of the longest reflux episode in patients classified into the following groups: group I--39 children with vomiting/excessive regurgitation, group II--29 infants with persistent distress/inconsolable crying, group III--16 children with Apparent Life Threatening Events (ALTE), group IV--28 infants with chronic/recurrent respiratory system diseases. No statistically significant difference was noted between the groups in pH parameters at the distal esophageal level, whereas at the proximal level the differences included only the number of reflux episodes. However, we found, that by using the ANOVA test, the incidence was higher in group IV than in group II. As determined by applying Mann-Whitney rank sum test, reflux episodes occurred most frequently in group IV, than in other groups of patients (including controls). None of the reflux parameters recorded at the proximal level among children presenting with ALTE was statistically significantly different than in other groups.
Pol Merkur Lekarski 2003 May
PMID:[Dual simultaneous esophageal pH monitoring in infants with gastroesophageal reflux]. 1293 13

The aim of this study was the assessment of citric acid cough threshold in patients with chronic cough due to GERD, confirmed by 24-hour esophageal pH- monitoring, with other reasons of chronic cough excluded. Thirty subjects with chronic cough due to GERD and 15 healthy volunteers underwent cough challenge with doubling concentrations of citric acid using Asthma Provocation System (Jaeger). The cough threshold was defined as the first concentration of citric acid that induced cough. Spirometric parameters (FEV, PEF and FVC) were measured before and 10 minutes after cough challenge in all groups. A day and night cough score diaries (verbal category descriptive score) were completed in all subjects. The cough threshold was significantly lower in GERD patients in comparison with healthy volunteers. In GERD patients the negative correlation was found between day cough score measurements and cough threshold. Citric acid cough challenge did not cause bronchoconstriction or any significant change of spirometric parameters.
Pneumonol Alergol Pol 2003
PMID:[Assessment of cough threshold in patients with gastroesophageal reflux disease]. 1458 28

Gastroesophageal reflux disease (GERD) is considered an important etiological factor of numerous larynx dysfunctions. The goal of our study was to describe larynx status of patients with GERD before and after treatment. Forty-five patients with GERD symptoms entered our study. GERD was confirmed in 24-hours pH-metric examination. Patients were treated with proton pump inhibitors in doses chosen accordingly to GERD severity. All patients underwent endoscopic evaluation of the larynx and acoustic voice analysis before and after the treatment. GERD was diagnosed in 35 out of 45 patients. Acoustic voice analysis revealed that voice disorders appeared more often in patients with severe than moderate or mild refluxes (p = 0.023). Laryngeal changes found in endoscopic evaluation also depended on reflux severity (p = 0.05). The voice quality improved (p = 0.031) and the changes in larynx diminished after anti-reflux treatment (p = 0.016).
Otolaryngol Pol 2003
PMID:[Laryngeal symptoms in patients with gastroesophageal reflux diseases]. 1504 81

The aim of the study was long-term observation of patients with gastroesophageal reflux (GER), diagnosed in their infancy, in aspect of spontaneous resolution of this disorder. 290 symptomatic infants aged 5 weeks to 11 months (mean--5.8 months) underwent 24-hour esophageal pH monitoring. In 243 (83.8%) patients, abnormal reflux score was observed. After one year of conservative therapy, follow-up study by esophageal pH-monitoring has been performed in 136 (46.9%) children and still showed pathological GER in 95 (69.8%) subjects. After 2 years, 45 (15.5%) patients has been investigated--14/45 (31.0%) of them had normal reflux score. At the following five-year clinical observation was available group of 28/290 (9.6%) patients. In the 2-3 year of their life, 13 of them had resolved symptoms and had normal acid reflux parameters, whereas 9 patients still had pathological GER. In the following years, basing of results of 24-hour pH monitoring, pathological GER persisted: in 7 children in age 4, in 5 subjects in age 5 and in 3 children over fifth year of life. Long-term clinical follow-up of these children is necessary because of risk of GER complications.
Pol Merkur Lekarski 2004 Mar
PMID:[Long-term clinical observation of infants with gastroesophageal reflux]. 1519 May 91

Gastro-esophageal reflux disease (GERD) is one of the most important problems of gastroenterology at present. The symptoms of GERD have negative influence of patients' life on a daily basis. The principal aim of reflux disease treatment is to eliminate or alleviate the symptoms, to heal tissue damages and to reduce the frequency and duration of recurrences. Lifestyle and dietary modification are of only limited value in GERD treatment. Proton pump inhibitors (PPI) are the mainstay of GERD pharmacotherapy for both initial episode and long-term management. Surgical treatment is indicated in: complicated GERD, in patients who need high effective dose of medication, young patients who need lifelong PPI, patients with big hiatus hernia. Laparoscopic Nissen fundoplication has become the operation of choice. Nevertheless patients who have undergone fundoplication may experience adverse post operative complication. The useful alternatives in the management of GERD may indeed eventually prove the new endoscopic methods of minimally invasive treatment which are currently under thorough evaluation. The most promising methods of endoscopic treatment of GERD have been discussed: radiofrequency ablation (the Streett's procedure), endoscopic gastroplasty, endoscopic implantation of biopolymer hydrogel prosthesis.
Pol Merkur Lekarski 2004 Mar
PMID:[Endoscopic treatment of gastroesophageal reflux disease--new possibilities]. 1519 Jun 8

The aim of this study was to determine the prevalence of gastroesophageal reflux disease (GERD) in patient with asthma, its relation to the severity of asthma, BMI (body mass index) and method of treatment. Two hundred eight patients with asthma were included in the study. All patients were carefully studied for asthma severity and surveyed using questionnaire specific for diagnosis of GERD also BMI was determined. Among the asthmatics 22.1% had chronic severe asthma, 43.3% had chronic moderate asthma and 34.6% had chronic mild asthma. GERD was present in 86.9% of patients with severe asthma (p<0.001 as compared to moderate and mild asthma), 62.2% of patients with moderate asthma and 48.6% of patients with mild asthma. BMI was significantly higher in patients with severe asthma and reached 28+/-5.3 kg/m2. GERD was present in all patients with severe asthma and BMI above 30 kg/m2. 72.5%, 17.85% and 8.6% of patients with severe, moderate and mild asthma respectively, experienced symptoms of GERD after ingestion of theophylline and oral steroids. The study demonstrated a greater prevalence of GERD symptoms in severe asthma and related GERD to BMI and treatment with theophylline and systemic steroids.
Pol Merkur Lekarski 2004 Jun
PMID:[Prevalence of gastroesophageal reflux disease in patients with bronchial asthma]. 1551 Aug 89

Oxygen free radicals trigger arachidonic acid peroxidation. The end-products of this reaction are malonyl dialdehyde (MDA) and conjugated dienes (CDs). The pattern of changes of MDA and CD concentrations in serum and esophagus mucosa homogenates were estimated in patients with GERD. The study was conducted on a group of 92 patients. They were divided into a non-esophagitis and co-existent esophagitis subgroup. The presence of inflammation was confirmed by means of pathomorphological examination. Results were verified against upper gastrointestinal tract endoscopy outcomes. The measurements were taken before and 8 weeks after anti-GERD treatment. Results were compared against 20 patients awaiting hernia repair. In both groups MDA serum concentrations before treatment were significantly different from the control group (2.02 nmol/mL in group I and 3.92 nmol/mL in group II). It decreased significantly after treatment in group II (2.72 nmol/mL) and insignificantly in group I. Also DS serum concentrations before treatment was significantly different comparing to the control group (1.34 nmol/mL in group I, and 2.13 nmol/mL in group II). Like MDA, dienes' concentrations decreased significantly after treatment in group II and insignificantly in group I. MDA and DS tissue concentrations were always higher than the serum ones. Both before and after treatment they displayed statistically significant differences between the esophagitis and non-esophagitis groups. Oxygen free radicals measured by means of MDA and DS serum and tissue homogenate concentrations rise significantly in patients with GERD compared to the control group. Arachidonic acid peroxidation products' concentrations were significantly higher in patients with GERD and esophagitis than in the non-esophagitis group.
Pol Merkur Lekarski 2004 Jun
PMID:[Effect of arachidonic acid peroxidation products on the development of gastroesophageal reflux disease]. 1551 Aug 90

Gastroesophageal reflux (GER) plays an important role in pathogenesis of recurrent/chronic disorders of the respiratory tract. Atypical symptoms of GER can be suggested to be cause of the otorhinolaryngological problems. For these last manifestations no cause-effect relationship has yet been proven. There are many therapeutic studies, in which treatment of GERD is examined for its impact on coexisting respiratory disorders. The aim of our study was to confirm the presence of acid reflux by using 24-hour intraesophageal pH monitoring. From the group of 29 patients with recurrent episodes of the pharyngitis, laryngitis and tracheitis, we evaluated 18 children aged 3 months to 8 years (mean, 4.23 +/- 2.85) with coexisting reflux symptoms. The protocol included a parenteral interview, physical examination, roentgenograms of the chest and larynx, laryngoscopy, as well as 24-hour simultaneous proximal and distal esophageal pH monitoring. The most significant differences between examined patients and control subjects was noted in terms of the lowest pH value, number of reflux episodes and index reflux while pH dropped below 4. Every significant drop under pH 6 recorded in proximal esophagus was simultaneous with reflux episode in distal esophagus. We found increased both sensitivity and specificity of the simultaneous pH monitoring in the distal and proximal part of the esophagus comparing to monitoring by the single probe. We confirmed the presence of gastroesophagopharyngeal reflux in patients with recurrent disorders of pharynx, larynx and/or trachea.
Pol Merkur Lekarski 2004 May
PMID:[Gastroesophagopharyngeal reflux in infants and children with recurrent symptoms of the upper respiratory tract]. 1551 27


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