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Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Bernstein test has been applied for over 30 years in the diagnosis of the causes of pyrosis. Its drawback is a considerable percentage of false positive results in healthy persons, caused by a too large amount of 0.1 M HCl given. Presented in the paper are studied results in 34 patients with symptoms of gastroesophageal reflux disease (GERD), and in 23 healthy persons in which into the body of the esophagus and into the cardia was given alternately 0.1 M HCl and 0.15 M NaCl at a speed of 0.8 cm3.min-1. During the testing the complaints reported by the patients were recorded, and by means of polyphysiograph the spasms of the body of the esophagus were recorded and morphologically assessed. In addition, in 12 volunteers of 23 healthy persons Bernstein classic test was carried out by giving them alternately 0.1 M HCl and 0.15 M NaCl at a speed of 0.8 cm3 x min-1. The testing carried out shows that a reduction in the amount of acid given in Bernstein test causes a decrease in the percentage of false positive results in healthy persons. HCl infusion into the body of the esophagus and into the cardia in patients with symptoms of GERD caused pathological motility in the body of the esophagus. The most frequent anomaly were multipeaked spasms, which can be an additional diagnostic criterion of this disease.
Mater Med Pol
PMID:Assessment of clinical value of Bernstein test and attempts of its modification. 130 43

In 16 patients with symptomatic gastroesophageal reflux disease (GERD) 24-h intraesophageal pH monitoring (Medilog 1010, Oxford) was carried out after placebo, cisapride (4 x 5 mg) and cimetidine (3 x 200 mg plus 400 mg at bedtime). The per cent time at which intraesophageal pH < 4.0 (refluxive time) was analysed. Cisapride shortened daytime and postprandial refluxive time from 16.1 +/- 14.5% and 12.6 +/- 9.2% to 5.1 +/- 4.4% and 7.5 +/- 6.5%, respectively (p < 0.01, p < 0.05). Whereas, cimetidine shortened particularly night refluxive time from 24.7 +/- 14.1% to 8.8 +/- 6.9% (p < 0.01) and total time from 20.4 +/- 12.8% to 12.0 +/- 6.4% (p < 0.05).
Mater Med Pol
PMID:Effect of cisapride and cimetidine on 24-hour intraesophageal pH monitoring in patients with gastroesophageal reflux disease. 130 54

The action of metoclopramide was studied on peristaltic as well as antiperistaltic activity in frog stomach and guinea-pig ileum. It was observed that metoclopramide enhances normal peristaltic activity by acting on dopamine-receptors whereas it inhibits antiperistalsis by some unknown mechanism. It is, therefore, inferred that inhibition of antiperistaltic activity might be an additional mechanism for its antiemetic effect. It also explains the pharmacological basis for its use in oesophagitis due to gastro-oesophageal reflux.
Mater Med Pol
PMID:Effect of metoclopramide on peristalsis and antiperistalsis in isolated frog stomach and guinea-pig ileum. 249 Dec 69

Airway resistance (Raw) and functional residual capacity (FRC pl) were determined by plethysmography in 17 children aged 3 to 12 months. Gastroesophageal reflux was diagnosed on the ground of longterm monitoring of esophageal pH or the X-ray examination of the stomach. No elevated airway resistance was found. In 41% of the cases FRC (per kg of body weight) was increased. This indirectly indicates the diminished small airways patency.
Pediatr Pol 1989 Jun
PMID:[Functional status of the bronchial tree in infants with gastroesophageal reflux]. 263 69

16 children with various pulmonary symptoms were presented. Gastrooesophageal reflux was diagnosed as a cause of that. The causal correlation between gastrooesophageal reflux and respiratory symptoms was established on the ground of 24-hour monitoring of oesophageal pH, radioisotopic examination of the stomach and oesophagus, evaluation of the bronchial reactivity to the acidification of the oesophagus and of the allergic tests. Eventually surgical treatment was performed in all children which resulted in the complete remission of the symptoms or marked subjective improvement. It has been shown that gastrooesophageal reflux is an important cause of acute or chronic lung disease. The close collaboration should be established between pediatricians and pediatric surgeons in the treatment of gastrooesophageal reflux.
Pediatr Pol
PMID:[Gastroesophageal reflux and diseases of the respiratory system in children; etiopathogenesis, diagnosis and treatment]. 264 71

An analysis of the clinical picture of Barrett's esophagus in 18 children is presented. This group of patients have been distinguished out of 114 children with chronic gastroesophageal reflux on the base of anatomopathological examinations. Clinical course and efficiency of the diagnostic examinations depend on the degree of esophagitis. They are slightly characteristic in children with minimal lesions. Long-term follow up - necessary due to the risk of cancer - have shown that there is possibility of recovery in cases of minimal advancement and short duration of the disease.
Pol Tyg Lek 1989 Jan 23
PMID:[Barrett esophagus]. 279 13

13.5-year-old girl who was admitted to hospital because of anorexia nervosa started to complain of abdominal pain in her 3-rd week of hospitalization. She underwent 24-hour pH-metry and upper GI endoscopy. These procedures showed that GER was the cause of anorexia. Therapeutic management led to marked improvement.
Pediatr Pol 1996 May
PMID:[Anorexia as the main symptom of gastroesophageal reflux: case study of a 13.5-year-old girl]. 871 Apr 33

An effect of cimetidine and famotidine on the lower esophagus sphincter pressure and esophageal body motility has been investigated. The studies involved 30 patients with duodenal ulcer. The lower esophagus sphincter pressure, mean force and mean duration of spasms as well as wave transmission velocity in esophageal body, 1-13 cm above the sphincter, have been recorded with Polyphysiograph R-611. The lower esophagus sphincter pressure and esophageal body motility have been recorded 15 minutes prior to and following the administration of 200 mg cimetidine or 20 mg famotidine. It was shown that cimetidine has net changed the lower esophagus sphincter pressure and esophageal body motility parameters. Famotidine increased the lower esophagus sphincter pressure from the initial 2.31 +/- 1.19 kPa to 3.51 +/- 1.61 kPa (p < 0.05) and had no effect on the esophageal body motility parameters. It may be concluded that within H2-receptor antagonists famotidine may be considered a drug of choice in the treatment of gastroesophageal reflux.
Pol Tyg Lek 1996 Apr
PMID:[The effect of cimetidine and famotidine on esophageal motility]. 896 65

In the paper, on the basis of literature and of the authors own observations, the disorders resulting from smoking within the upper segment of the alimentary tract have been discussed. Tobacco has been identified as a factor substantially interfering in the motility of the upper segment of the alimentary tract and unfavourably influencing the gastric and duodenal mucosa. It explains its facilitating role in the pathogenesis of gastroesophageal reflux disease and a slower healing of peptic ulcers and also their more frequent relapse in smokers with a chronic peptic ulcer disease.
Pol Merkur Lekarski 1998 Aug
PMID:[Selected problems concerning harmful effects of smoking on the upper segment of the alimentary tract]. 1010 64

Changes in intraesophageal pH can influence myocardium perfusion via neural reflexes. The aim of this study was to estimate the relationships between intraesophageal pH and the course of electrocardiographic exercise test. 38 male patients with atypical chest pain in mean age 41.1 +/- 7.8 years were studied. In all among other 24-hours oesophageal pH monitoring and exercise test on running track with simultaneous oesophageal pH monitoring were made. Pathological acid reflux in 24-hours monitoring had 11 (29%) patients, exertional acid gastroesophageal reflux in 8 (21%) patients was found and significant ST interval depression in ecg in 11 (29%) patients was observed. The differences in patients quantity in respective subgroups were not significant. Patients with significant ST interval depression during exercise test, in comparison with patients without significant ecg changes, had lower HDL cholesterol level and higher values of daily and exertional gastroesophageal acid reflux parameters. Multiple-regression analysis showed that indicators of functional (pH-metry) and morphological (endoscopy and histology) oesophageal status were the independent factors determining variance of: exercise test duration, percentage of maximal heart rate during exercise test, double product value and maximal ST interval depression. In conclusion, changes in intraesophageal pH can influence exercise test course.
Pol Arch Med Wewn
PMID:[Relationship between results of electrocardiographic exercise tests and intraesophageal pH in men with atypical chest pain]. 1123 39


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