Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017168 (
gastroesophageal reflux disease
)
11,783
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
During routine typing procedures the individual
GER
was demonstrated to possess an unusual class II phenotype exhibiting three DR serotypes (
DR1
, DR2, DRw6). Closer serologic examination on this person's family showed that the
DR1
and DR2 antigens segregated together on one haplotype. Biochemical evidence will be presented that the B cell line derived from the individual
GER
expresses five distinct types of DR molecules. Antigen presentation studies proved that the DR molecules carrying either
DR1
, DR2, or DRw6 (DRw13) allodeterminants are not only coordinately expressed but also are functional. No evidence could be found for altered DQ expression. The implications of these findings for the evolutionary aspects of the MHC class II region will be discussed.
...
PMID:Molecular, serologic, and functional evidence for an apparent HLA-DR triplet. 348 13
