Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Electromyogram of the submental muscles, esophageal manometry, and pH studies were simultaneously performed in an unselected group of 12 patients with subjective and objective evidence of gastroesophageal reflux (GER) disease to determine the frequency of transient relaxation of the lower esophageal sphincter (LES) and mechanisms of GER. Findings from these patients were compared with data from 10 asymptomatic healthy volunteers. Recordings were obtained for 1 h in the fasting state and 3 h after a standard 850-kcal meal. Transient relaxation of the LES was the only mechanism of acid reflux in normal subjects and accounted for 73.0% of the episodes of acid reflux in patients with GER disease. In both normal subjects and patients with GER, a large number of transient relaxations were associated at their onset with an attenuated submental EMG complex, a small pharyngeal contraction, and an esophageal contraction. The incidences of these associated events were similar in the two study populations. The frequency of transient relaxation of the LES in patients with GER was identical to that of controls. The frequency did not differ even in 9 patients with GER disease who had endoscopic esophagitis. Thirty-six percent of transient relaxations in the normal subjects were accompanied by pH evidence of reflux, but in the GER patients with endoscopic esophagitis 65% of the transient LES relaxations resulted in a reflux event. Acid reflux at the moment of deep inspiration was the second most common mechanism of GER in our patients. Four patients who demonstrated this mechanism had hiatal hernias and more severe esophagitis than the rest of the group. Our findings confirm that transient relaxation of the LES is the major mechanism of GER in patients with reflux esophagitis. However, the similar frequency of this relaxation in GER patients and in healthy asymptomatic subjects suggests that factors other than transient LES relaxation play an important role in the pathogenesis of GER disease.
Gastroenterology 1988 Sep
PMID:Characteristics and frequency of transient relaxations of the lower esophageal sphincter in patients with reflux esophagitis. 339 10

The case of a 3-week-old male infant is described. After receiving an iatrogenic overdose of metoclopramide (1.0 mg/kg every six hours) throughout a 36-hour period for the treatment of suspected gastroesophageal reflux, he became cyanotic, lethargic, and irritable, he fed poorly, and he had diarrhea and respiratory distress. Methemoglobinemia (20.5%) and reduced oxyhemoglobin saturation (79%) were identified. The patient had an excellent clinical response following a single IV dose of methylene blue. Subsequently, methemoglobin reductase activity was normal and there was no measurable hemoglobin M. The diagnosis of methemoglobinemia should be considered in any infant receiving large doses of metoclopramide who has clinical findings of cyanosis, ashen color, or a history of lethargy and/or motor restlessness.
Pediatrics 1988 Sep
PMID:Metoclopramide-induced methemoglobinemia. 340 65

The aims of the present study were to evaluate the accuracy of 24-hr intraesophageal pH monitoring in the diagnosis of gastroesophageal reflux in the hospital setting and to establish whether there were any differences in terms of reflux events between patients with and without endoscopic esophagitis. Fifteen control subjects and 47 patients with proven gastroesophageal reflux disease were studied. A composite score of reflux events (number of reflux episodes; total, upright, and supine reflux time; number of refluxes lasting more than 5 min; and duration of the longest reflux) provided the best discrimination between controls and patients (94% sensitivity and 100% specificity). Patients with esophagitis showed concurrently a longer total reflux time and supine reflux time, and more prolonged reflux episodes than those without esophagitis. On the other hand the severity of esophagitis was directly related to the duration of both total and supine reflux. The results indicate that inpatient 24-hr pH-metry is very accurate in the diagnosis of gastroesophageal reflux. They also suggest that prolonged esophageal exposure to acid, particularly at night, and slow esophageal acid clearing are factors that determine the appearance and/or perpetuation of esophagitis in patients with reflux.
Dig Dis Sci 1988 Sep
PMID:Utility of inpatient 24-hour intraesophageal pH monitoring in diagnosis of gastroesophageal reflux. 340 99

Significant complications are encountered in some patients as a result of prolonged endotracheal intubation. The finding of low gastric pH values at postmortem examination in patients whose larynx was severely traumatized after endotracheal intubation suggested that gastroesophageal reflux (GER) is an important factor in the pathogenesis of these problems. To evaluate the occurrence and character of GER as well as its effects upon the larynx and trachea of intubated patients, clinical observations and several animal models were employed. Monitoring of pH values for GER was performed in intubated patients both in the operating room and the intensive care unit with a 40% incidence of GER in ICU patients not receiving antacid therapy. After exposure to gastric juice, marked inflammation and necrosis were observed in the larynx of rabbits, and a significant reduction of mucociliary flow was found to occur in the dog's trachea. The physiology and mechanisms of these events are discussed and indicate that GER may play an important role in the development of permanent laryngeal and tracheal injury in the intubated patient. It is recommended that pharyngeal pH be monitored in intubated patients because their altered state of consciousness may predispose to gastric reflux. When GER is encountered, initiation of treatment should be undertaken because prevention is considerably more effective than subsequent treatment.
Laryngoscope 1988 Sep
PMID:Gastroesophageal reflux as an etiologic factor in laryngeal complications of intubation. 341 96

One hundred patients with achalasia of the esophagus were analyzed at a late follow-up by means of subjective and objective parameters. The surgical technique consisted of an anterior esophagomyotomy (6 cm long, not extending into the stomach more than 5 to 10 mm) with the addition of an anterior hemi-Nissen or Dor procedure, similar to the Thal serosal patch. No operative deaths occurred. The mean follow-up was 6.8 years, and only 1 patient was lost from this follow-up. Preoperative dysphagia, which was present in 100% of the patients, persisted only occasionally in 8%, and a significant gain in weight was recorded in 90% of the patients. In three patients epidermoid carcinoma developed 5 to 9 years after surgery. In one patient a severe gastroesophageal reflux with an esophageal ulcer developed. Radiologic studies demonstrated a significant increase in the diameter at the gastroesophageal junction and a decrease at the middle third of the esophagus (p less than 0.0001). The resting pressure of the lower esophageal sphincter showed a significant decrease, from 37 mm Hg to 10 mm Hg, after surgery (p less than 0.0001), when we analyzed 84 patients before and 68 patients after operation. The total length of this sphincter also decreased. The manometric evaluation of the lower esophageal sphincter pressure in the same 42 patients before, 2 months after, and 5 to 7 years after surgery demonstrated persistence of the low sphincter pressure. There was a significant increase in the amplitude of the esophageal waves, and the standard acid-reflux test demonstrated reflux into the esophagus in 19% of the patients. Final clinical evaluation showed excellent and good results in 92 of the 94 controlled patients.
Surgery 1988 Sep
PMID:Late subjective and objective evaluation of the results of esophagomyotomy in 100 patients with achalasia of the esophagus. 341 76

We describe the medical odyssey of two infants who turned out to be constitutionally short. The measurements of length gradually came to rank below the fifth percentile during the first 18 months of life. Numerous tests were performed, and the diagnosis of gastroesophageal reflux led to fundoplication. The concept that higher energy intakes result in greater increases in length led eventually to gastrostomy. Increases in weight during gastrostomy feedings had no effect on growth in length. It was very difficult to convince the parents that the gastrostomies were not necessary. The parents had in fact become "gastrostomy dependent." The vague concept of "failure to thrive" proved to be misleading and obscured the knowledge that constitutionally short children can fall below the fifth percentile in length at any time before the age of 2 or 3 years.
Am J Dis Child 1988 Sep
PMID:Gastrostomy dependence in two constitutionally short children. 341 23

The effect of 150 mg ranitidine twice daily was compared with placebo by the double-blind crossover technique (8 weeks twice) in patients with gastro-oesophageal reflux (paired comparison in 38 patients). Ranitidine was superior to placebo with regard to effect on symptoms, improvement of oesophagitis as assessed by endoscopy and biopsy, and decrease of oesophageal acid hypersensitivity. The symptomatic response to ranitidine was, however, unsatisfactory in more than half of the cases. When symptomatic responders taking ranitidine (R) were compared with non-responders (NR), there was no difference with regard to the severity of oesophagitis or frequency of positive acid perfusion tests before or after the 8-week treatment. NR were younger and more often had endoscopic signs of incompetence of the cardia and gastric prolapse. Ranitidine is an efficient drug in patients with reflux disease. It cannot be expected that mechanical problems in the hiatal region will be influenced by ranitidine, which is probably why half the patients did not respond.
Scand J Gastroenterol 1986 Sep
PMID:Double-blind crossover study of ranitidine and placebo in gastro-oesophageal reflux disease. 353 4

The study comprises 31 patients with gastro-oesophageal reflux disease who received 8 weeks' treatment with ranitidine. Sixteen of the patients received in addition maintenance treatment with ranitidine (150 mg twice daily) for another 6 months, and fundoplication was performed on 15 patients. There was a significant improvement in endoscopic and histologic findings, a decrease in gastric acid secretion, and a reduction of symptoms during short-term treatment with ranitidine. No further improvement was seen in any of the factors after half a year of ranitidine. After surgery the total reflux time during 24 h decreased to practically zero, all patients had normal endoscopic findings and negative acid perfusion tests, and reflux symptoms had disappeared completely. Anti-reflux surgery was superior to treatment with ranitidine. Reflux oesophagitis is therefore not improved any further by a half year's treatment with ranitidine beyond what is achieved with short-term therapy.
Scand J Gastroenterol 1986 Sep
PMID:Maintenance treatment with ranitidine compared with fundoplication in gastro-oesophageal reflux disease. 353 5

Eighteen patients with progressive systemic sclerosis and symptomatic gastroesophageal reflux were studied for 20 weeks. All patients were initially treated with ranitidine for a 6-week period. From the 7th week the patients were randomized to further treatment with either ranitidine or placebo. Heartburn and dysphagia, the endoscopic appearance of the esophageal mucosa, the esophageal motility, and gastroesophageal reflux were assessed during the study. The efficacy of ranitidine was maintained during the 20-week period. A shift to placebo was recognized by the patients almost immediately and caused heartburn and esophageal mucosal inflammation to increase significantly.
Scand J Gastroenterol 1986 Sep
PMID:Long-term ranitidine in progressive systemic sclerosis (scleroderma) with gastroesophageal reflux. 353 6

Gastro-oesophageal reflux (GOR) occurs with increased frequency in asthmatics. GOR may cause pulmonary symptoms either by reflux of gastric contents into the trachea or by a reflex mechanism. Several studies have shown that the presence of acid in the oesophagus may induce slight bronchospasm. However, more recent studies have clearly demonstrated that acidification of the oesophagus may exacerbate the bronchial hyperreactivity characteristic of the asthmatic patient, thus rendering the patient more susceptible to bronchoconstriction by other stimuli. As some drugs used in the treatment of asthma decrease lower oesophageal sphincter pressure and thereby enhance GOR, a vicious circle may arise. As surgical and medical anti-reflux therapy has been shown to be effective in diminishing asthmatic symptoms in the asthmatic patient with proven GOR, 24-hour ambulatory oesophageal pH monitoring is recommended in order to detect such patients and give them a trial with an H2 receptor antagonist.
Schweiz Med Wochenschr 1986 Sep 27
PMID:[Gastroesophageal reflux and asthma]. 353 63


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