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Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Distal oesophageal pH was monitored for three hours after a standard meal in 10 young healthy subjects without symptoms of gastro-oesophageal reflux. Episodes of reflux occurred in nine of these subjects; and, in five, oesophageal pH was less than 5 for between 11 and 75% of the first postprandial hour. Intermittent incompetence of the lower oesophageal sphincter after food must, therefore, be regarded as a normal phenomenon. The method described would be suitable for the evaluation of agents believed to weaken or to strengthen the lower oesophageal sphincter.
Gut 1977 Sep
PMID:Postprandial gastro-oesophageal reflux in healthy people. 2 83

Further report on the importance of routine "water test" in the demonstration of an unsuspected gastroesophageal reflux and possible associated reflux esophagitis. Analysis based on 24,106 consecutive and unselected gastrointestinal tract examinations and description of the technique.
Radiol Med 1979 Sep
PMID:[The water test in the demonstration of gastroesophageal reflux and of an unsuspected reflux esophagitis (author's transl)]. 55 43

Two patients had both scleroderma and a columnar epithelium-lined lower esophagus (Barrett esophagus). Features of Barrett's esophagus included high esophageal strictures in both patients and ulcer craters in the columnar area of one. Biopsy confirmed columnar epithelium in the lower esophagus of each patient. In these patients, the Barrett esophagus probably was a complication of scleroderma and resulted from long-standing gastroesophageal reflux.
Mayo Clin Proc 1978 Sep
PMID:Barrett's esophagus occurring as a complication of scleroderma. 68 90

In summary, the recent understanding of the pathogenesis of gastroesophageal reflux disease as owing to LES incompetence has led to improvement in both the diagnosis and the treatment of this disorder. Diagnosis now dependent on demonstrating the presence of reflux, an incompetent sphincter mechanism, or some complication of reflux. Treatment is focused on reducing the endogenous factors that contribute to reflux, or actually restoring the sphincteral barrier to reflux by pharmacologic or surgical means.
Arch Intern Med 1978 Sep
PMID:The pathophysiology and treatment of gastroesophageal reflux disease: new concepts. 68 32

New manometric techniques in for examining the lower oesophageal sphincter (LOS) were applied an investigation of the oesophago-gastric junction after partial gastric resection. Pressure and blood gastrin data are reported for eight cases examined before and after surgery, under basal conditions and after stimulation with a protein meal. It was found that gastric resection leads to a decrease in LOS performance (43.6% fall in maximum pressure) and length (-33.3%). There is also a 93.5% decrease in the pressure response to a protein meal, and hence a predisposition to gastroesophageal reflux.
Minerva Chir 1978 Sep 15
PMID:[The lower esophageal sphincter in gastrectomized patients. Manometric study]. 69 88

Among 457 esophageal stenosis treated between 1954 and 1977, 258 (56%) were caustic stenosis. The treatment of those is the most difficult. Functionnal healding was satisfactory in 93% of the treated cases by dilatations. Four strict rules ought to be observed in the management of this cases. Immediate and long terme antibiotic treatment of the corrosive esophagitis. X rays are the only means to be used during evolution of corrosive esophagitis. No instrumental performance until sufficient cicatrization. Retrograde dilatations after gastrostomy shall be prefered in serious cases. Gastro-esophageal reflux may complicate this evolution and require surgery. Total esophageal replacement can be averted in most cases.
Ann Otolaryngol Chir Cervicofac 1978 Sep
PMID:[Assessment of a thirty year long experience in treatment of esophageal caustic stenosis (author's transl)]. 74 87

A modified end-to-side esophagogastrostomy devised at our department to prevent postoperative reflux was evaluated both experimentally in 15 dogs and clinically in 4 cases. The seromuscular coat of the anterior wall of the remnant stomach was excised longitudinally, the distal esophagus was buried and anastomosed at its distal end so as to provide an effective thin flap valve. The presence of gastroesophageal reflux was attested by the use of withdrawal pH, intraluminal pressure and fluoroscopy studies as well as by autopsy in dogs. Furthermore, 7 out of 15 dogs were subjected to the analytical study of reflux prevention mechanism employing an intraoperative pressure measurement. The results are summarized as follows: Gastroesophageal reflux was absent in 11 out of 15 dogs and in all the 4 clinical cases. A specific finding after this procedure was that even after resection of the cardia, there was seen creation of an artificial high pressure zone at the site of the anastomosis serving as a barrier to reflux. Reflux prevention mechanism of the present method lies in an effective flap valve mechanism which seals the distal esophagus receiving the side pressure from the artificial fundus. The procedure is technically easy and seems to serve overcoming the problem of postoperative reflux highly seen after conventional end-to-end or end-to-side esophagogastrostomy.
Nihon Heikatsukin Gakkai Zasshi 1978 Sep
PMID:[Experimental and clinical studies on anti-reflux effect of modified end-to-side esophagogastrostomy in proximal gastrectomy (author's transl)]. 75 Jun 88

Findings in this study correlated a low circulating gastrin level with an incompetent lower esophageal sphincter mechanism and abnormal reflux. Such reflux, in amounts causing esophagitis distally, was treated surgically by a mechanically simple method of fundoplication. The success of this reefing method of fundoplication was explained by using physiologically active sling fibers of the gastric fundus to augment the lower esophageal sphincter. Available gastrin was used more effectively in this manner. The high incidence of associated foregut diseases suggested an embryologic factor in the development of gastroesophageal reflux. The dilated hiatus and its attendant hernia had no apparent relationship to the development of reflux esophagitis. The term symptomatic sliding hiatal hernia, therefore, seemed to be a diagnostic and therapeutic misnomer.
Surg Gynecol Obstet 1976 Sep
PMID:The role of gastrin in the treatment of sliding hiatal hernia with reflux using the reefing method of fundoplication. 78 38

In spite of numerous experimental and clinical studies the pathogenesis of the disease resulting from pathological gastroesophageal reflux is yet unsettled. The importance of hiatus hernia has been questioned. The disturbed function of the lower esophageal sphincter does not always explain the occurrence of increased gastroesophageal reflux. there is no correlation between symptoms (pyrosis) and the typical esophageal mucosal changes which are best demonstrated by means of endoscopy. Guided biopsy is usually not necessary. Medical therapy consists in application of antacids, most effectively in combination with alginic acid. Further help can be expected from stimulation of the lower esophageal sphincter with metoclopramide and/or cholinergic drugs. Further measures are elevation of the head of the bed (30 degrees), reduction of body weight if necessary (to reduce intraabdominal pressure) and a high protein, low fat diet. Operative intervention (fundoplicatio) is rarely indicated, mostly in case of stricture.
Fortschr Med 1977 Sep 15
PMID:[Therapy of gastroesophageal reflux]. 90 73

A case of complicated spontaneous esophageal perforation is presented. The control of gastroesophageal reflux by esophageal banding appears to be a crucial factor in healing. Using a modified esophageal exclusion technique without sacrifice of the esophagus proves to be both effective and lifesaving.
Chest 1976 Sep
PMID:Modified exclusion technique for complicated esophageal perforation. 95 69


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