Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017168 (
gastroesophageal reflux disease
)
11,783
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Esophageal dysfunctions occur frequently in patients with diabetic autonomic neuropathy, and the complication of
gastroesophageal reflux disease
(
GERD
) has also been reported. However, the characteristics of the
GERD
complicated with diabetes are obscure, because no detail assessment was performed. We recorded esophageal motility and acid reflux simultaneously in diabetic patients, and the correlation between esophageal dysfunction and diabetic neuropathy was examined. Esophageal dysfunctions including
GERD
were significantly related to diabetic motor neuropathy. Although the
GERD
is frequently complicated with diabetes, the symptoms are not apparent in diabetic patients. Therefore, physicians treating diabetic patients should have
GERD
in mind regardless of the symptoms. We also examined the effect of
aldose reductase
inhibitor (ARI) on the esophageal dysfunction in diabetic patients. Significant improvement of
gastroesophageal reflux
and esophageal motility were observed in diabetic patients by ARI treatment. ARI may be useful for the treatment of
GERD
complicated with diabetes.
...
PMID:[Gastroesophageal reflux disease in diabetic patients]. 1534 49
