Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A ringlike structure around the cardia has proven to be sufficient in preventing gastroesophageal reflux, as seen with the Angelchick prosthesis. To avoid the insertion of a nonabsorbable foreign body, a scarring was induced by implanting a Vicryl scarf around the esophagogastric junction. Reflux disease was induced in 18 dogs by circular cardiomyomectomy. In 12 dogs, a Vicryl scarf was laid around the cardia; six dogs served as controls. All of the dogs in the control group either died or had to be sacrificed due to severe reflux esophagitis. All animals receiving the scarf survived the entire duration of the experiment. Endoscopically, only one case of temporary reflux esophagitis could be detected. Long-term pH-metry demonstrated complete reflux suppression after the third postoperative month. Radiographically, esophagogastric transit was always unimpaired. On autopsy, the scarf was found to have changed into a slim scarring after the sixth postoperative month and then remained unaltered. We conclude that inducing scarring around the cardia is as effective in reflux prevention as the silicone ring.
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PMID:Vicryl-scarf-induced scarring around esophagogastric junction as treatment of esophageal reflux disease. An experimental study in the dog. 158 92

Severe gastroesophageal reflux was accomplished in 18 dogs by circular cardiomyectomy. After this intervention a Vicryl scarf was placed around the cardia in 12 dogs. The Vicryl scarf was absorbed within 6 months and in its place remained a scarred tissue. In the follow up gastroesophageal reflux could not be detected by manometry, pH-metry, radiology and endoscopy. In the control group all 6 dogs died within 3 weeks due to complications of gastroesophageal reflux. On the basis of these data the Vicryl scarf implantation is an effective, simple, new antireflux operation which can be initiated into the human surgical practice.
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PMID:[Can gastroesophageal reflux be prevented by inducing a scar tissue ring around the cardia?]. 162 58