Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Diurnal variations in the pattern of esophageal motility and acidity were studied in 14 healthy volunteers. Data from a two-channel manometry and one-channel pH-metry recording were stored in a portable 1-MByte, solid-state data logger for subsequent computerised analysis. Comparison of predefined nighttime, mealtime and nonmeal daytime periods showed that propagated contractions predominated during mealtimes (56% of all contractions) and nonmeal daytime periods (53.5% of contractions) and that their propagation velocity (2.98 cm/sec) was at its lowest and the AUC of all contractions (134.6 hectoPascal.sec) at its greatest during mealtime periods. During the night, propagated contractions (0.136/min) and simultaneous contractions (0.025/min) were significantly less frequent than during both meal (1.31/min and 0.172/min, respectively) and nonmeal daytimes (0.665/min and 0.133/min, respectively), whereas the nocturnal segmental contraction frequency (0.181/min) was not significantly lower than the nonmeal daytime contraction frequency (0.243/min). Median reflux time was in the normal range (1.2%), although two subjects had prolonged reflux times (9.5% and 14.5%). In conclusion, all subjects showed similar patterns of diurnal esophageal contractory activity determined partly by meal intake and partly by a characteristic clustering of nocturnal contractions that could not be explained by episodes of nocturnal gastroesophageal reflux. It may, therefore, be speculated that nocturnal contraction clusters are associated with rhythmic phenomena such as MMC or specific sleep stages.
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PMID:Twenty-four-hour pattern of esophageal motility in asymptomatic volunteers. 220 86

Control of breathing, bronchomotor tone and lung function are inferior to circadian rhythms, which can already be demonstrated at healthy subjects. They get relevant especially at patients with obstructive airway disease and sleep disturbances. Particularly in the early morning hours flow resistance in the airways and in the nose rises. Several different mechanisms are suspected to be responsible: Allergen exposure in bed, supine position, interruption of the bronchodilator therapy, gastro-oesophageal reflux, tenseness of the airways and secretory accumulation. Connected to nocturnal asthma might also be an increased airway responsiveness. Several factors contribute to nocturnal asthma, but they don't constitute a general concept for the explanation of nightly exacerbations. Many hormonal neural cellular and humoral factors show diurnal fluctuations which favour a constrictive bronchial response in the night. Diurnal or ultradian changes in O2 and CO2 sensitivity only play a minor role. However, we have to realise alterations in the responses of the central neuronal control mechanisms of breathing within the respiratory cycle. Oscillations of arterial CO2 partial pressure or pH-values influence tidal volume and ventilation directly. Circadian changes of different vital functions cause minor alterations in airway responsiveness and airway resistance in normal subjects, however in patients with asthma they are enlarged in amplitude and become relevant especially in the night and early morning hours.
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PMID:[Chronobiology of the bronchial system]. 924 91

Circadian rhythm is driven by the molecular circadian-clock system and regulates many physiological functions. Diurnal rhythms in the gastrointestinal tract are known to be related to feeding pattern, but whether these rhythms are also related to the gastrointestinal damage or injuries; for example, gastroesophageal reflux disease (GERD), is unclear. This study was conducted to determine whether expression of circadian-clock genes or factors involved in vagal stimulation or sensitization were altered in the esophagus of GERD patients. Diurnal patterns of PER1, PER2, BMAL1, CRY2, TRPV1, and NGF mRNA expression were found in patient controls, and these patterns were altered and significantly correlated to the GERD severity in GERD patients. Although levels of CRY1, TIM, CB1, NHE3, GDNF, and TAC1 mRNA expression did not show diurnal patterns, they were elevated and also correlated with GERD severity in GERD patients. Finally, strong correlations among PER1, TRPV1, NGF and CRY2 mRNA expression, and among PER2, TRPV1 and CRY2 expression were found. Expression levels of CRY1 mRNA highly correlated with levels of TIM, CB1, NHE3, GDNF and TAC1. This study suggests that the circadian rhythm in the esophagus may be important for the mediation of and/or the response to erosive damage in GERD patients.
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PMID:Changes in Gene Expression Patterns of Circadian-Clock, Transient Receptor Potential Vanilloid-1 and Nerve Growth Factor in Inflamed Human Esophagus. 2633 63