Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Severe gastroesophageal reflux disease is usually a chronic problem with periods of relapse, but effective medical and surgical therapies are available. Two recently introduced agents, omeprazole (Prilosec) and cisapride (Propulsid), represent advances in medical therapy; the safety of long-term, continuous omeprazole therapy is under investigation. Used by surgeons with sufficient experience, the new laparoscopic approach offers potential advantages over conventional anti-reflux surgery in suitable candidates. The decision of whether to recommend long-term medical therapy or surgery must be individualized. Medical therapy may be the best choice in elderly patients and poor surgical candidates, in patients whose symptoms are well controlled with omeprazole and who accept its benefit-risk profile, and when a highly experienced anti-reflux surgeon is not available. Surgery may be appropriate (assuming a skilled surgeon is available) in patients who are young, have trouble taking medication, need multiple agents to control symptoms, and need continuous omeprazole therapy but are unwilling to accept the theoretical risk of gastric carcinoid tumors that accompanies it.
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PMID:Severe gastroesophageal reflux disease. Medical and surgical options for long-term care. 775 50

Gastro-oesophageal reflux disease is a primary motility disorder of the upper gastro-intestinal tract, with varying degrees of disturbed lower oesophageal sphincter function, disturbed peristalsis of the oesophageal body and delayed gastric emptying. Traditional treatment has focused on "detoxifying" the refluxate by suppressing gastric acid secretion. With the advent of cisapride (Prepulsid), prokinetic drugs offer a possibility of influencing the underlying motility disturbances without causing the serious side effects of earlier prokinetic drugs. It seems to be well documented that cisapride is useful in both the short-term and the long-term treatment of grade 1 reflux oesophagitis, and also in more severe cases as part of combination regimens involving acid suppressive drugs.
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PMID:[Prokinetics in reflux disease. Action mechanisms and clinical effects]. 819 52

Propulsid is indicated in the treatment of patients with nocturnal heartburn due to gastroesophageal reflux disease. Propulsid administration increases lower esophageal sphincter pressure and increases esophageal acid clearance.
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PMID:Propulsid (cisapride). 819 88