Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Proton pump inhibitor (PPI) is major treatment for acid reflux. It reduces major symptom of GERD and effective. However, the cause of GERD is the insufficiency of anti-reflux mechanism of cardia. Only surgical treatment can care for hiatal hernia as the main cause of the disruption. Redundant reflux against conservative treatment or obvious hiatal hernia is indication for laparoscopic Nissen fundoplication. Late diagnosis might request radical operation, so we need to know the indication for laparoscopic treatment. For the safer laparoscopic procedure, we perform curtain retraction technique and Floppy Nissen -short cuff method. The former contribute to prevent hemorrhage or pneumothorax, and the latter can reduce the post-operative disphagia.
 ...
PMID:[Surgical treatment for gastroesophageal reflux disease (GERD)]. 1751 Dec 31

About 10% (per cent) of world population have Hiatal hernia and gastro-esophageal reflux diseases of different forms. From this amount of people 1/5 need required surgical treatment. The goal of the thesis is to show the results and effectiveness of laparoscopic surgical treatment of this disease. In 2005-2013. at out clinics (Thoracoabdominal clinic and Caraps Medline) had been performed 145 laparoscopic fundoplications. Were used as Nissen Method with its modifications (Floppy Nissen, Classic Nissen and Nissen Rosset), as well as "Toupet" and "Dor" methods of fundoplication. From 145 cases were 84 - female, 61 - male. Age ranged from 24 to 76. From performed 145 operations in 97 cases was done Floppy Nissen Fundoplication, 23 cases - Nissen-Rosset modification, 5 cases - Classic Nissen. Toupet method Partial Fundoplication was done in 17 cases and anterior Fundopexia - Dor method - was done in 3 cases. Using various methods of laparoscopic fundoplication, due to the analysis of our results, the perfect positive result was achieved in 93.2% (per cent).
...
PMID:Laparoscopic surgery of hiatal hernia and gastro-esophageal reflux disease. 2502 Jan 64