Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ischemic heart disease (IHD) and gastroesophageal reflux disease (GERD) are among the most common diseases worldwide, which in a considerable percentage of cases occur together, thus complicating symptoms, posing problems for timely diagnosis and hindering development of a comprehensive treatment regimen for both diseases. Research has shown that endothelial dysfunction is one of the major pathophysiological mechanisms in the development of IHD. Endothelial dysfunction also affects regional perfusion of the esophagus, thus compromising esophageal tissue defense mechanisms. The aim of our study was to investigate the role of endothelial dysfunction in the mechanisms of GERD development in patients with IHD. For the purpose of this study, we collected data on serum levels of endothelin-1, nitric oxide metabolites and lipid peroxidation products, gastric pH, parameters of regional blood flow, and quality of life assessment. Study results revealed that in IHD patients with concomitant GERD, endothelial dysfunction manifested by a significant increase in the levels of endothelin-1 and lipid peroxidation products, with decreased levels of nitric oxide metabolites, regional blood flow and quality of life. These findings suggest that hypoxia of the esophageal mucosa, caused by endothelial dysfunction, leads to a decrease in the esophageal tissue resistance and to esophageal lower sphincter dysfunction, which, in turn, are the leading factors in the development of GERD.
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PMID:The Role of Endothelial Dysfunction in the Mechanism of Gastroesophageal Reflux Disease Development in Patients with Ischemic Heart Disease. 2959 Jul 16

The elderly patients problem is comorbidity - concurrent presence of different diseases. Coronary artery disease (CAD) and gastroesophageal reflux disease (GERD) are one of the most common diseases worldwide that in a considerable percentage of cases occur together. The aim of our study was to investigate features of endothelial dysfunction in old people with CAD and concomitant GERD. Endothelial dysfunction manifests itself as a decrease in stable nitric oxide metabolite levels and an increase in endothelin-1 levels, disturbance of celiac trunk regional blood flow, causing a decrease in oesophageal tissue resistance, leading to lower oesophageal sphincter dysfunction. Endothelial dysfunction is one of the leading mechanisms of GERD development in people with CAD, while in people with isolated GERD, endothelial dysfunction is secondary, exacerbating the disease presentation.
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PMID:FEATURES OF ENDOTHELIAL DYSFUNCTION IN ELDERLY PERSONS WITH CORONARY HEART DISEASE AND CONCOMITANT GASTROESOPHAGEAL REFLUX DISEASE. 3095 93