Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Unsettled behaviour in the first few months of life is a common clinical problem, with the associated risks of postnatal depression, premature cessation of breastfeeding, long-term psychological disturbance, and child abuse. Parents of new babies complain of difficulty accessing appropriate care and receiving conflicting advice. Although organic disturbance is implicated in only 5% of cases, gastro-oesophageal reflux disease, food allergies and lactose intolerance are often mistakenly diagnosed in unsettled babies. There is no evidence that acid-suppressive medications help in treating unsettled behaviour and, until the hypothesis that proton-pump inhibitors may predispose to food allergies has been properly investigated, treatment with acid-suppressive medications should be avoided in this population. Although unsettled behaviour in infants is commonly a transient neurodevelopmental phenomenon that peaks at 6 weeks of age, failure to diagnose other correctable problems, including breastfeeding difficulty and cows milk allergy, risks entrenching anxiety and disrupted mother-infant interactions in the long term. In the current climate of health system reform, the design and evaluation of an integrated, evidence-based, multidisciplinary primary care approach to management of unsettled babies and their mothers is a priority.
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PMID:The unsettled baby: crying out for an integrated, multidisciplinary primary care approach. 2103 88

Asthma is a common chronic respiratory disease in children. The diagnosis of asthma in children may be associated with other comorbidities, which may influence the disease in several ways, including optimal asthma control. The main objective of this study was to determine the association of common comorbidities with asthma in children between 5 and 15 years. A cross-sectional study was carried out in a tertiary care hospital of western Rajasthan. A set of 23 questions were offered to the children with asthma and/or their parents and their responses were noted manually. A total of 95 children (74 male) were enrolled, allergic rhinitis (AR) was documented in 72 (75%) followed by psychological disturbance in 68 (71%), snoring in 47 (49.5%), gastro-esophageal reflux disease (GERD) in 44 (46.3%), atopic dermatitis in 26 (27.3%), and sinusitis in 19 (20%) children. There was no statistical significant association observed between asthma comorbidities and gender. Allergic rhinitis was the most common comorbidity in children with asthma followed by psychological disturbance, GER, and snoring. Both boys and girls had similar prevalence of asthma comorbidities.
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PMID:Association of common comorbidities with asthma in children: a cross-sectional study. 3196 36