Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In our country, it is reported that reflux esophagitis(GERD) has been increasing like in European countries. One of the reasons for this tendency may be the arrival of the aging society. Another explanation is the lowering of Helicobacter pylori infection rate in the younger generation. Though the Los Angeles classification is mainly used at present, the Savary-Miller classification is also clinically important. For the initial treatment of GERD, proton pump inhibitor(PPI) has been mainly used, while there is large problems in the ideal way of maintenance therapy. The guideline on the GERD treatment is also being considered, based on EBM.
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PMID:[Clinical update of GERD]. 1100 4

The endpoints should be settled before the treatment of GERD. These are symptom relief, healing and maintenance of erosive or ulcerative lesions, and also probably prevention of several complications of GERD. In medical treatment for GERD, we can take some different strategies, that is, single-agent, step-up or step-down therapy. The authors reviewed the effects of many drugs, being used for GERD therapy, and decided the levels of therapeutic effects from the view point of EBM. Using these results, we recommended that the therapy of GERD should be started with PPI of a regular dose and stepped-down in usual cases, but it should be begun with PPI and stepped-up in refractory cases. PPI may be necessary also for maintenance treatment in most latter cases. The guideline of the treatment for GERD were discussed.
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PMID:[Guideline for treatment of gastroesophageal reflux disease]. 1100 13