Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of this prospective study was to assess the effects of highly selective vagotomy on lower esophageal sphincter pressure, and to determine whether or not it leads to increased gastroesophageal reflux. Fifteen patients (4 females, 11 males), mean age 43 years (22-63) suffering from duodenal ulcer without any clinical or pH evidence of gastroesophageal reflux were treated by highly selective vagotomy. All of them were studied before and 3-6 months after operation by history taking, pH reflux, manometric, and acid secretory pentagastrin tests. After operation none of the 15 patients had clinical evidence of duodenal ulcer or gastroesophageal reflux. The basal and stimulated acid outputs were decreased after vagotomy; pre and postoperative values were 6.8 +/- 8.9 mmol/h and 0.9 +/- 1.6 mmol/h; 42.2 +/- 10.3 mmol/h and 21.4 +/- 6.4 mmol/h, for BAO and PAO respectively (p less than 0.001). The lower esophageal sphincter pressure was 22.5 +/- 5.6 cm H20 before and 21.1 +/- 4.9 cm H20 after surgery (p less than 0.01). None of the values were lower than normal. There was no significant difference in pH reflux tests; the total duration of pH less than 5 reflux was 1.2 +/- 2.1 p. 100 before, and 1.9 +/- 2.8 p. 100 after vagotomy. These results suggest that an efficient highly selective vagotomy does not impair lower esophageal sphincter efficiency in patients-without gastroesophageal reflux, and that the routine addition of an antireflux procedure is not well advised.
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PMID:[Effect of proximal gastric vagotomy on the competence of the lower sphincter of the esophagus]. 273 77

The relationship between GAS and oesophageal reflux complications in patients with hiatal hernia and incompetent antireflux mechanism is a matter of controversy. In a study of 70 patients operated upon for hiatal hernia, BAO and PAO after betazole stimulation were studied preoperatively in relation to oesophageal reflux complications, age and oesophageal motility. No correlation was found between BAO and oesophageal reflux complications. There was no association between PAO and such complications in patients with oesophageal hypomotility whereas PAO was clearly correlated to these complications in patients with normal oesophageal motility. Oesophageal reflux complications were closely correlated to oesophageal hypomotility and age.
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PMID:Gastric acid secretion (GAS) and hiatal hernia. I. Relationship between GAS and oesophageal reflux complications. 722 98

The indications for surgical procedures reducing gastric acid secretion in patients with hiatal hernia and symptomatic gastroesophageal reflux remain unclear. In a study of the postoperative results in 40 patients operated upon with modified Husfeldt hernia repair only, the results were assessed in relation to BAO and PAO. No correlation was found between the clinical results and BAO or PAO in patients in whom the reflux was successfully corrected by the procedure. It is concluded that gastric acid-reducing procedures are not indicated in patients in whom correction of reflux is anticipated.
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PMID:Gastric acid secretion (GAS) and hiatal hernia. II. Relationship between GAS and clinical results after hernia repair. 722 99