Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Among nearly 1 300 infants and children studied for chronic or recurrent respiratory diseases 36 of them had plasma and/or salivary IgA deficiency. They were 1 to 13 years of age with 20 between 3 to 6 years; 11 had total, lack or traces of salivary IgA, 9 had very low or nul plasma IgA titer and 6 had both. The deficiency was transitory in 10. Associated abnormalities with potential liability for the disease: allergy, gastroesophageal reflux, alpha-1-antitrypsin deficiency and other immunologic deficiency were encountered in 26. The often multifactorial pattern of respiratory diseases in pediatrics is emphasized. The pathogenic role of IgA deficiency is discussed. Even though its responsibility is demonstrated, its real magnitude and extent requires further studies.
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PMID:[Recurrent respiratory disease and IgA deficiency in infants and children (author's transl)]. 626 3

Persistent pneumonia associated with H1N1 influenza infection is a rarely reported clinical entity. The authors describe the case of an infant who presented to the emergency department with respiratory distress and a 30-day history of intermittent cough and breathing difficulty. Low grade gastro-oesophageal reflux (GER) was a possible cause for the patient's persistent lower respiratory tract symptoms. However, despite appropriate and adequate therapy for GER, his symptoms persisted and he worsened a week after admission. A search for causes of persistent pneumonia showed positive results for H1N1 virus and isolated IgA deficiency. IgA deficiency in an infant with H1N1 infection has not been previously reported. Inability to mount an adequate local immune response due to deficiency of the antibody could have led to the persistence of symptoms in this case. Screening of family members for the source of infection revealed that the mother was positive for the virus. The authors report this case to highlight the need to rule out underlying IgA deficiency in children with an atypical course of H1N1 pneumonia.
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PMID:H1N1 infection associated with persistent lower respiratory tract illness in an infant with isolated IgA deficiency. 2266 68

Collagenous gastritis, without colonic involvement, is exceptionally rare. It is not known to be associated with IgA deficiency and scleroderma. This is the first report of this type of association. We present a 26-year-old white female with a past medical history of gastroesophageal reflux disease and scleroderma. She was evaluated for complaints of abdominal pain and diarrhea. Esophagogastroduodenoscopy showed gastritis and duodenitis. Colonoscopy was normal. The histopathological report showed collagenous gastritis and focal lymphocytic duodenitis. A definitive treatment has not been established for this condition. Reporting such cases furthers understanding of the disease and will help to establish diagnostic criteria and to develop therapeutic strategies.
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PMID:Collagenous Gastritis in a Young Female With IgA Deficiency. 2849 34