Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Over a period of 14 years, 1246 patients had emergency gastroscopy because of upper gastrointestinal tract (UGIT) bleeding. The endoscopic findings in these patients showed duodenal ulcer disease (DUD) in 364 (29.2%) was the most common followed by esophageal varices in 302 (24.2%), erosive gastritis in 198 (15.9%), gastroesophageal reflux disease (GERD) in 156 (12.5%), gastric ulcer in 69 (5.5%), and normal (negative) endoscopy in 132 (10.6%). Only 65 (21.5%) patients with varices had active bleeding from the esophageal varices, 10 (3.3%) from the gastric varices and in 34 other patients with varices (11.3%), the bleeding was mainly from associated gastrophy. Eighty-six patients (23.6%) with DUD had active bleeding at endoscopy; 66 (80.5%) of these had ulcers showing stigmata of recent hemorrhage. Of those who had active bleeding, the source of the bleeding could not be identified in only five.
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PMID:Causes of upper gastrointestinal bleeding: Experience at a major hospital in Riyadh. 1758 20

The study included 190 patients divided in to 5 groups: 20 normal as healthy control complaining of dyspepsia, GERD etc., 20 patients positive HCV without cirrhosis or varices, 50 patients compensated cirrhosis with varices, 50 patients decompensated cirrhosis with varices and 50 patients with primary acute variceal bleeding. All were subjected to full history taking, clinical examination, routine laboratory examinations including serum pre-albumin, abdominal ultrasonography, MELD score was calculated for all patients, Child classification for all patient and upper gastrointestinal endoscopy. The results showed that platelet count was lowest in patients with varices, decrease of platelet count with increase of grading of esophageal varices. Platelet count was lowest in patients with early bleeding esophageal varices at 6 weeks in comparison to patients with bleeding esophageal varices at 4 months and patients with bleeding esophageal varices at 6 months. MELD score proved to be sensitive and specific in differentiation between patients with and without varices. The increasing of MELD score with increase of grade of varices pre albumin (PA) was lowest in patient with esophageal variceS and decrease of PA level with increase of grade of varices.
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PMID:Prognostic and predictive values of MELD score, platelet count and pre-albumin in patients with compensated and decompensated liver cirrhosis with acute variceal bleeding. 2321 21


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