Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The endoscopic and morphological changes in esophagus of 71 patients with ulcer disease, accompanied with gastroesophageal reflux were studied, with following up of 10 histological signs in the multi-layer pavement epithelium of esophagus at the same time quantitatively evaluated. It has been established that morphological signs of esophagitis develop in case of gastroesophageal reflux among ulcer patients to 53.5%, being twice more frequent in duodenal ulcer than in gastric. Among the histological signs of reflux-esophagitis higher papillae were established, as well as thickening of the basal-cellular layer, vacuolization of spinous-like and granular layer, parakeratosis. Granulocytic infiltration was established in reflux-esophagitis with pronounced endoscopic destructive changes.
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PMID:[Endoscopic and morphological research on the changes in the esophageal mucosa in peptic ulcer combined with gastroesophageal reflux]. 371 59

The aim of the article was to study morphological features of esophageal mucosa in patients with type II diabetes mellitus and gastroesophageal reflux disease (GERD). The research was conducted on 67 patients with type II diabetes mellitus and GERD and 50 non-diabetic patients with GERD. The histological study of the mucous membrane of the distal esophagus in patients with combined pathology detected parakeratosis and acanthosis, outflows edema and bundles epithelium, surfacial hyperplasia, infiltration of neutrophils and vascular ectasia. The obtained results demonstrate that type II diabetes causes change in symptoms, endoscopic and histologic manifestations of GERD. It is concluded about the importance to develop and improve diagnostic tools for the detection of GERD with type II diabetes by means of invasive and non-invasive diagnostic techniques.
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PMID:[Morphological peculiarities of esophageal mucosa in patients with gastroesophageal reflux disease and type ii diabetes mellitus]. 2463 43