Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Over the last ten years (1984-1994), 124 patients undergo one-stage operations for diseases of the heart valves and coronary arteries and other surgical conditions. This makes 3.38 per cent of the total of 3661 patients subjected to open-heart surgery in the observation period. The indications for undertaking surgical treatment in the series of 124 patients reviewed are classified in three groups, as follows: Group A. Life-threatening conditions due to concomitant surgical disease (bleeding from the gastrointestinal tract, acute calculus cholecystitis, obstructive jaundice, peritonitis, end-stage pregnancy)--16 patients. Group B: Serious non-heart surgical diseases (malignancy, hypersplenism, aneurysm of the abdominal aorta)--47 patients. Group C. Non-heart diseases giving rise to serious complaints and life style deterioration (advanced inguinal hernia, hiatal hernia with gastroesophageal reflux, duodenal ulcus, thyroidism, etc.)--61 patients. The early postoperative mortality and complications rates--2.41 per cent and 3.22 per cent, respectively--do not differ essentially from those in patients with open-heart surgery alone. One-stage surgical procedures after careful assessment of the indications are recommended.
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PMID:[One-stage operations in pathology of the heart valves and coronary vessels and other general surgical diseases in 124 patients]. 747 57

We present the case of a 7-month-old girl with Gaucher disease who required anesthetic care during laryngoscopy, bronchoscopy, and central line placement. Gaucher disease is a familial disorder of lipid catabolism with autosomal recessive inheritance. Due to the defective function of the enzyme glucosylceramide beta-glucosidase, glycosphingolipids accumulate, leading to end-organ dysfunction. Three clinical variants of the disease, which differ in age of onset, degree of central nervous system (CNS) involvement, and frequency in the population, have been described. Of concern to the anesthesiologist is the occurrence of significant CNS dysfunction in types II and III, with seizures, gastroesophageal reflux, and chronic aspiration. Bulbar involvement and infiltration of the upper airway with glycolipids may lead to upper airway obstruction. Additionally, hepatosplenomegaly, present in all three variants, may lead to hypersplenism with thrombocytopenia and anemia. Preoperative identification of the associated end-organ dysfunction will allow the safe provision of anesthetic care for these children.
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PMID:Anesthetic considerations in the child with Gaucher disease. 809 1