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Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Respiratory distress, apnea, and chronic pulmonary disease since birth were identified in 14 infants who also had symptomatic gastroesophageal reflux. Birth weights varied from 760 to 4,540 gm. All infants had radiographic changes similar to those in bronchopulmonary dysplasia. Cessation of apnea and improvement of pulmonary disease occurred only after medical (8) or surgical (6) control of gastroesophageal reflux. Simultaneous tracings of esophageal pH, heart rate, impedance pneumography, and nasal air flow in five infants demonstrated that reflux preceded apnea. Apnea could be induced by instillation of dilute acid, but not water or formula, into the esophagus. Prolonged monitoring of esophageal pH more than two hours after feeding in 14 other infants less than 6 weeks of age (birth weight 780 to 3,350 gm) without a history of recent vomiting indicated that reflux was not greater than in normal older children.
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PMID:Gastroesophageal reflux causing respiratory distress and apnea in newborn infants. 3 84

Twelve-hour simultaneous registration of acid gastro-oesophageal reflux and peristaltic activity in the oesophagus was carried out on 30 healthy subjects. The intensity of the acid gastro-oesophageal reflux was determined by automatic integration of the pH variation. Acid gastro-oesophageal reflux to pH less than or equal to 4 occurs in normal subjects within a range of 0--2.4% of the total registration period. The intravariation was measured in 10 investigations on 1 subject, and lay within the intervariation. To maintain the pressure-measuring system intact, 3 ml H2O/h were fed to the proximal and distal pressure catheters, respectively; it has been shown that this small quantity of water has no influence on the pH variation. Peristaltic activity for the entire measuring period was recorded and related to the individual reflex episodes. The total activity was found to be dependent on the level of consciousness, with little activity occurring during sleep. A positive correlation was found between the lowest pH during a reflux episode and the peristaltic activity in the oesophagus (p less than 0.001), between the lowest pH during a reflux episode and the duration of the reflux episode (p less than 0.001), and between the peristaltic activity and the duration of the reflux episode (p less than 0.001). During long-term registration of oesophageal pH it appears that pH less than or equal to 4 is a usable parameter for distinguishing between pathological and non-pathological acid gastro-oesophageal reflux. Sudden falls in pH to below 4 release increased peristalsis in the oesophagus.
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PMID:12-Hour simultaneous registration of acid reflex and peristaltic activity in the oesophagus. A study in normal subjects. 4 Mar 3

Symptomatic infants displayed three patterns of gastroesophageal reflux after drinking apple juice (20 ml/kg or 300 ml/m2 of body surface area). The type I pattern occurred in patients who had continuous postcibal gastroesophageal reflux, large hiatal hernias and frequently required an antireflux operation. A functional motility disorder suggesting delayed gastric emptying appeared to be important in infants with discontinuous reflux (type II pattern). These infants had frequent gastroesophageal reflux for only 2 3/4 hours postcibally, antral-pylorospasm, increased low esophageal sphincter pressures, and a high incidence of pulmonary symptoms and non-specific watery diarrhea. The mixed (type III) pattern of gastroesophageal reflux occurred in a small number of infants and exhibited features of both type I and II patterns.
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PMID:Patterns of postcibal gastroesophageal reflux in symptomatic infants. 4 57

Following a hemorrhage, ten patients with esophageal varices were examined by means of gastroscopy and functional analysis of the esophagus with special regard to gastroesophageal reflux. A pathological gastroesophageal reflux was not confirmed. These results plus previously published findings lead to the assumption that reflux is of not importance in the initiation of esophageal variceal bleeding.
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PMID:[Gastroesophageal reflux: a factor eliciting esophageal variceal hemorrhage?]. 4 87

Continuous pH measurements were undertaken by 87 patients (17 without, 30 with small, 40 with heavy symptons of reflux) for the study of gastroesophageal reflux 1 hour before and after standardized meal. A significant increase of reflux was shown by 19 patients with reflux under dry conditions, whereas reflux was demonstrated by 47 patients for the first time. After meal provocation of reflux was shown by patients with typical symptoms of reflux. An increase of reflux was shown the heavier reflux sumptoms were. pH measurements of gastroesophageal reflux seem to improve the evidence of results after such standardized meal.
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PMID:[Studies about influence of food on gastroesophageal reflux. I. pH measurements before and after standardized meal (author's transl)]. 4 25

Twenty-two patients with chronic upper dyspepsia but without ulcer disease were examined for gastro-oesophageal reflux and gastro-oesophageal sphincter pressure. Thirteen had an abnormal duodenal loop and nine a normal duodenum. An increased incidence of gastro-oesophageal reflux was found in patients with abnormal duodenal loop, whereas no differences were seen in the gastro-oesophageal sphincter pressure.
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PMID:Gastro-oesophageal sphincter pressure and reflux in controls and patients with abnormal duodenal loop. 4 88

Esophageal function was evaluated in 51 children less than 2 years of age with radiologic evidence of gastroesophageal reflux. Detection of an acid esophageal pH was a sensitive measure of gastroesophageal reflux. Lower esophageal sphincter pressures were greater in reflux patients with respiratory symptoms (18.0 +/- 1.4 mm Hg) than in reflux patients without respiratory symptoms (9.5 +/- 1.0 mm Hg). The intra-abdominal segment of the lower esophageal sphincter was shorter in patients with reflux than in controls (0.51 +/- 0.05 cm vs. 0.75 +/- 0.08 cm). It was also shorter in patients requiring surgical therapy (0.34 +/- 0.05 cm) than in those responding to medical therapy (0.63 +/- 0.07 cm).
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PMID:The lower esophageal sphincter in gastroesophageal reflux in children. 4 40

A preliminary communication on the excellent results of a new intraluminal prosthesis for palliative intubation of advanced oesophageal of cardial carcinoma is reported. Such prothesis includes an original and effective device to avoid gastro-oesophageal reflux and the ensuing peptic oesophagitis. Piloroplasty is considered convenient as an adjuvant in the prevention of gastro-oesophageal reflux.
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PMID:[Intubation of neoplastic esophageal stenoses. A new prosthesis with an antireflux device]. 5 13

Twenty-seven patients with symptomatic gastro-oesophageal reflux received cimetidine 1.6 g daily for 6 weeks and matching placebo for 6 weeks in a randomised double-blind crossover trial. They complained of significantly more episodes of pain on placebo than on cimetidine (1186 vs 581) and consumed significantly more antacid tablets on placebo than on cimetidine (1645 vs. 1011). Cimetidine and placebo had similar effects on mucosal sensitivity to acid and on oesophagitis assessed endoscopically and histologically, suggesting that the symptomatic benefit is the result of a simple antacid effect.
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PMID:Effect of cimetidine in symptomatic gastro-oesophageal reflux. 8 86

Between 1949 and 1976, 899 patients underwent treatment for achalasia of the esophagus at the Mayo Clinic, 431 by forceful hydrostatic or pneumatic dilation and 468 by a standardized transthoracic esophagomyotomy. Esophageal leak and mediastinal sepsis was an uncommon but major complication of both types of therapy, occurring four times more often with dilation (4%) than with myotomy (1%), although no deaths resulted from this in either group. The 30-day mortality was 0.2% after myotomy and 0.5% after forceful dilation. Although there was minimal morbidity and mortality with either modality, the late results were significantly superior after myotomy. Excellent to good results were obtained by 85% of the group treated with myotomy but only by 65% of those treated with hydrostatic dilation. Late poor results were encountered three times more frequently after dilation (19%) than after myotomy (6%). Analysis of poor results after myotomy indicates that late serious complications of gastroesophageal reflux developed in only 3% of patients operated on.
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PMID:Esophagomyotomy versus forceful dilation for achalasia of the esophagus: results in 899 patients. 8 37


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