Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Between 1976-1987, 408 patients were studied for Reflux Esophagitis. Clinical, endoscopic, manometric characteristic were analyzed, and scintigraphic studies for gastroesophageal and duodenogastric reflux were done. Esophagitis was classified according endoscopic findings in Esophagitis grade I (non confluent erosion), grade II (confluent erosions), grade III ("uncomplicated Barrett syndrome") and grade IV (esophageal ulcer or stricture ("complicated Barrett syndrome"). Fifty six (56) patients with mild (grade I), 52 with moderate (grade II) and 146 patients with severe esophagitis (56 grade III, and 90 grade IV) were included in this protocol. No significative differences were found in clinical feature except dysphagia and bleeding, symptoms more frequent in severe esophagitis than mild or moderate grades. Lower esophageal sphincter pressure was similar in both groups of patients, but the frequency of motor disorders was significative higher in severe esophagitis. Scintigraphic gastroesophageal reflux was positive in all patients and no differences in gastric emptying and duodenogastric reflux were detected. In conclusion, the differences in subjective and objective analysis between different grade of esophagitis suggest to employ different models of management.
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PMID:[Clinical and laboratory correlation of severe esophagitis compared to mild or moderate esophagitis]. 260 19

The effectiveness of cimetidine (30-40 mg/kg/day) was evaluated in 32 children with gastroesophageal reflux disease complicated by esophagitis who entered a random double-blind trial for 12 weeks. Esophagitis was diagnosed in all patients by endoscopy with biopsy. Seventeen patients (age, mean +/- SD: 21.7 +/- 37.65 months) received cimetidine (c-pts), and 15 (age, mean +/- SD: 29.03 +/- 39.73 months) received a placebo (p-pts). All patients received intensive postural therapy. Based on clinical and endoscopic (and histologic) data, 12 c-pts and three p-pts were healed (p less than 0.01), the condition of four c-pts and three p-pts had improved (not statistically significant), and the condition of one c-pt and nine p-pts had worsened (p less than 0.01). Both clinical and esophagitis scores significantly decreased only in the c-pt group, as compared with p-pts. Improvement of esophagitis was seen in all (100%) of c-pts with mild or moderate esophagitis versus 57.14% of p-pts (p less than 0.01) and in 87.5% of c-pts with severe esophagitis as compared with 25% of the p-pt group (p less than 0.01). We conclude that cimetidine is an effective agent for treatment of reflux esophagitis in children. Although gastroesophageal reflux disease in infancy has a naturally self-limited course with conservative care (thickened feedings and posture adjustment), extensive pharmacologic therapy is needed in the presence of esophagitis.
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PMID:Cimetidine treatment of reflux esophagitis in children: an Italian multicentric study. 265 32

Symptomatic gastroesophageal reflux is a common medical problem. But only few data exist on the epidemiology of reflux disease (without inflammation) and reflux esophagitis. The literature is critically reviewed and ecological causes of gastroesophageal reflux are discussed. The prevalence of reflux esophagitis in Western countries is estimated to be 2% and that of reflux disease 5%. Sparse reports exist on the natural history of both diseases. They appear to have little if any effect on life expectancy. The main complications of reflux esophagitis are Barrett's esophagus, peptic stricture, ulceration and bleeding.
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PMID:Epidemiology of reflux disease and reflux esophagitis. 266 90

The possible effect of hiatal hernia, reflux esophagitis, and glucagon on the quality of the double-contrast esophagram was studied in 177 patients. Overall, the quality of the double-contrast esophageal views were judged poor in 46 (26%) patients and good in 131 (74%). No significant improvement in quality was evident in patients receiving glucagon, or in those with hiatal hernia or documented reflux esophagitis. Although the presence of gastroesophageal reflux or the lowering of esophageal sphincter pressure by glucagon would be expected to promote gaseous reflux from the stomach, no improvement in the quality of the double-contrast views of the esophagus was evident in our study.
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PMID:Effects of hiatal hernia, reflux esophagitis, and glucagon on the quality of double-contrast esophagram. 270 46

A series of 82 subjects affected with reflux esophagitis is presented. Gastroesophageal reflux and peptic esophagitis were discovered and staged by contrast meal and endoscopy with biopsy. All patients underwent medical therapy based on drugs affecting gastroesophageal motility and acidity of gastric content: this therapy was administered for three months, then was performed a control endoscopic examination. Endoscopic recovery of esophagitis allowed a long term maintenance therapy, endoscopically controlled every year. When esophagitis persisted, cycles of medical attack therapy, were repeated. surgical operation was performed in 15 cases in which either three cycles of medical therapy failed to improve esophageal lesions, or when endoscopy showed worsening esophagitis.
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PMID:[Role of conservative therapy and surgical treatment in disease caused by gastroesophageal reflux]. 273 42

Peptic esophagitis is a common complication of gastroesophageal reflux. Therapeutic measures aimed at reinforcing the anti-gastroesophageal reflux barrier, reducing acid secretion, or increasing the defense mechanisms of the esophageal mucosa are used to treat this form of esophagitis. The purpose of this study was to determine the efficacy of sucralfate in the treatment of peptic esophagitis in children. We studied 75 patients diagnosed endoscopically as suffering from esophagitis. The age of the patients ranged from three months to 13 years. Gastroesophageal reflux was diagnosed by isotopic investigation and/or radiologically. None of the patients had kidney disease or had received anti-inflammatory drugs, sucralfate, or cimetidine during the preceding two weeks. The patients were divided into three groups of 25. Patients were homogeneous in age, sex, nutritional status, symptoms, and grade of esophagitis. All patients in each group were treated with cimetidine, sucralfate tablets, or sucralfate suspension. No other dietary or postural measures were prescribed. Clinical examinations were carried out on Days 14, 28, 42, and 56, with an endoscopic examination on Day 28. Endoscopy was repeated on Day 56 if the course was unsatisfactory. Statistical examination of the data showed that there were no differences between the three groups. Sucralfate is a useful drug for the treatment of peptic esophagitis in children.
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PMID:Sucralfate versus cimetidine in the treatment of reflux esophagitis in children. 273 38

In order to evaluate the use of sucralfate in the treatment of children with reflux esophagitis, we studied 66 children aged from 4 months to 12 years (mean 5.9 years, SD 3.5) diagnosed to have gastroesophageal reflux by means of esophageal isotopic examination and radiology. An endoscopic examination was carried out in all cases. None of the patients suffered from kidney disease or had taken antacids, cimetidine, sucralfate or antirheumatic drugs in the two weeks prior to the study. Patients were divided into three groups matched according to age, grade of esophagitis, sex, nutritional state and semiology and treated with sucralfate in tablets, cimetidine, or sucralfate in suspension; no dietetic or postural measures were used. On days 14, 28, 42 and 56, clinical control was carried out and endoscopy was done on day 28, this being repeated on day 56 if the course was not satisfactory. From the statistical analysis of the results we deduce that there are no differences between the three groups. Therefore sucralfate appears to be a useful drug for the treatment of children with esophagitis due to GER.
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PMID:Sucralfate in the treatment of reflux esophagitis in children. Preliminary results. 274 Aug 41

Patients with severe reflux esophagitis unresponsive to standard medical therapy constitute a vexing clinical problem. We evaluated 8 patients with long-standing gastroesophageal reflux disease complicated by peptic stricture (n = 6), Barrett's esophagus (n = 5), bleeding esophageal ulcer (n = 2), and/or failure or prior antireflux surgery (n = 4), and 4 patients with rapidly advancing esophagitis following surgical resection of the cardia. After an 8-week course of full-dose H2-receptor antagonists, domperidone and antacids, marginal clinical improvement and unchanged or worsened endoscopic appearance of esophagitis was observed in all patients. Thereafter, in an attempt to enhance esophageal mucosal resistance, sucralfate alone (4.0 g/d) was given for 8 weeks. Both symptoms and endoscopic appearance improved in all patients after sucralfate, and the need for dilatation of strictures was lessened. On follow-up, complete healing of esophagitis was demonstrated by endoscopy in 6 patients after 4 to 6 months of uninterrupted sucralfate therapy. The results of this pilot study indicate that (cyto)protection with sucralfate has an important therapeutic potential in reflux esophagitis. They also suggest that impaired esophageal epithelial resistance is an important pathophysiological factor in persistence of esophageal inflammation in esophagitis refractory to conventional treatment.
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PMID:Efficacy of sucralfate in refractory reflux esophagitis. Results of a pilot study. 274 Aug 42

446 patients with an active peptic ulcer were examined. In 81.2% of them gastroesophageal reflux was found. In 220 patients the changes in the esophageal mucosa were studied morphologically. The patients were classified into groups according to their age and the duration of the disease. In 70.3% of the patients with a history of peptic ulcer over 15 years a reflux esophagitis was found and in 34.5% of the patients it was well expressed while in only 39% of the patients with a 5 year history of the disease a reflux esophagitis was found histologically and it was well expressed in 8.1% of them. Gastroesophageal reflux and reflux esophagitis are more frequent in patients over 40 years of age and in these patients the more severe forms prevail. The longer is the duration of the disease the greater is the number of cases with well expressed destructive changes.
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PMID:[Effect of age and the duration of the peptic ulcer on reflux changes of the esophageal mucosa]. 277 57

Gastroesophageal reflux and its resultant esophagitis are common complications following removal of the middle and lower part of the esophagus as well as the gastric cardia with reconstruction by simple esophagogastrostomy. Twenty-one dogs were randomly divided into 3 groups: (1) LES preserving group; (2) Nissen's fundoplication group; (3) Sweet's esophagogastrostomy group. Results by esophageal manometry, X-ray video tape recorder, and pathological examination respectively, 3 months postoperatively were compared. Esophageal manometry showed that the pressure of the preserved LES was still present. X-ray video tape recorder revealed that antireflex function was present in the preserved LES. Pathological examination confirmed no signs of reflux esophagitis in the mucosal specimen of the preserved LES group. We concluded that LES is the main barrier of gastroesophageal reflux. The intrathoracic LES could still have the function of anti-reflux.
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PMID:[Experimental study of antigastroesophageal reflux by preservation of the lower esophageal sphincter]. 277 40


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