Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Bulimia nervosa, an eating disorder now recognized with increasing frequency, is receiving growing attention because of purported complications. Recent claims of a high frequency of erosions, ulceration, and bleeding in the esophagus, ascribed to repeated, self-induced vomiting, prompted us to investigate by endoscopy the upper gastrointestinal mucosa in 37 consecutive patients with long-standing bulimia nervosa. The endoscopic appearance of esophageal and gastric mucosa was normal in 23 patients. Signs of mild esophagitis observed in eight patients were not related to the duration or severity of bulimic behavior or to symptoms of gastroesophageal reflux; two of these eight patients had sliding hiatal hernias. The remaining six patients were found to have superficial mucosal erythema in the stomach or duodenum, but none showed actual erosions, ulcers, or bleeding. Our observations suggest that, in contrast to reports by others, mucosal injury consequent to chronic, self-induced vomiting in patients with bulimia nervosa is relatively infrequent and limited.
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PMID:Upper gastrointestinal endoscopy findings in patients with long-standing bulimia nervosa. 259 94

Acid reflux, which is the entry of acidic gastric contents into the upper gastrointestinal tract, may manifest as two clinical syndromes-gastroesophageal reflux and/or laryngopharyngeal reflux. The latter syndrome, laryngopharyngeal reflux, is associated with the symptom of hoarseness. In the literature on eating disorders, according to general articles on medical complications, case reports, review articles on reflux, and empirical research, patients with self-induced vomiting (e.g., anorexia nervosa binge-eating purging type, bulimia nervosa purging type) are at risk for acid reflux, potentially culminating in either reflux syndrome. Because of the unique voice effects encountered with laryngopharyngeal reflux, hoarseness may be an indistinct clinical indicator of an eating-disorder syndrome characterized by self-induced vomiting-particularly when present in a young female of normal weight or underweight status. Thus, hoarseness in young women may suggest an eating disorder, both in psychiatric and primary care settings.
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PMID:Hoarseness: a sign of self-induced vomiting? 2319 76

Bulimia nervosa is an eating disorder characterized by consuming a large amount of food in a short amount of time followed by an attempt to rid oneself of the food consumed (purging), typically by vomiting, taking a laxative, diuretic, or stimulant, and/or excessive exercise, because of an extensive concern for body weight. The frequent contact between teeth and gastric acid, in particular, may cause: severe dental erosion, perimolysis, or the erosion of tooth enamel and swollen salivary glands. Constant vomiting can lead to gastroesophageal reflux. The aim of this article is to report two cases of patients with severe dental demineralization associated with bulimia nervosa during orthodontic treatment. Diagnosis and prevention aspects are highlighted and discussed.
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PMID:Dental white spots associated with bulimia nervosa in orthodontic patients. 2442 44

A middle school girl started a diet; she developed an eating disorder, and was diagnosed with anorexia nervosa. Endoscopic examination revealed no esophagitis due to gastric reflux, but slackness was seen in the cardiac region. Multichannel intraluminal impedance pH monitoring revealed marked non-acidic reflux. On the basis of positive symptom index (SI) and symptom association probability (SAP) values, the patient was diagnosed with non-erosive gastroesophageal reflux. The patient was afraid to eat because of the reflux; therefore, laparoscopic reflux prevention surgery was performed. The symptoms completely disappeared after surgery, and normal oral ingestion was possible.
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PMID:[Non-erosive gastroesophageal reflux disease in a teenager misdiagnosed as anorexia nervosa]. 2480 34

Individuals have different risks for developing erosive lesions depending on background, behavioural, dietary and medical variables. It is anticipated that people with regular impact of gastric juice, i.e. patients with eating disorders and gastroesophageal reflux disease (GERD) have a specially high risk of developing dental erosions; the same could be true for those with special diets, regular consumption of acidic beverages, medicine and drug intake and occupational exposure to acids. Eating disorders are associated with an increased occurrence, severity and risk for dental erosion, even though not all bulimic patients show a pathological level of tooth wear. There seems also to be a tendency that in the case of GERD, erosion is more common and more severe than in healthy controls. Regarding exogenous causes, many studies, though not all, document a positive association between the consumption of acidic beverages and dental erosions and there seems to be a dose-response relationship; however, further studies are necessary for a final statement. The same applies for the association between drug or medication intake or special diet and erosion prevalence. Though only few studies exist, there seems to be a tendency for an increase of erosion prevalence amongst persons abusively consuming alcohol. Some studies show an increased risk for dental erosion for employees testing wine or working in acid processing factories. Even though some associations between acid impact and erosion prevalence appear clear, the number of studies is small. There is a lack of controlled prevalence studies, making it difficult to give final statements for all risk groups.
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PMID:Prevalence of erosive tooth wear in risk groups. 2499 59