Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0017168 (gastroesophageal reflux disease)
 11,783 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

13.5-year-old girl who was admitted to hospital because of anorexia nervosa started to complain of abdominal pain in her 3-rd week of hospitalization. She underwent 24-hour pH-metry and upper GI endoscopy. These procedures showed that GER was the cause of anorexia. Therapeutic management led to marked improvement.
 ...
PMID:[Anorexia as the main symptom of gastroesophageal reflux: case study of a 13.5-year-old girl]. 871 Apr 33

We have studied 18 patients with anorexia nervosa with antroduodenal manometry for 24 hours and also 24 hours oesophageal pH studies. After the first 12 hours of measurements we started treatment with Cisapride (n = 8) or Erythromycin (n = 10) in a blind study. The results of measurements reveal a severe gastroesophageal reflux in 4 patients. Antroduodenal manometry showed dysfunctions in gastric motility, without relation with weight loss or duration of the disease. Cisapride and more so Erythromycin favor gastrointestinal motility.
 ...
PMID:[Anorexia nervosa or somatic disease]. 1154 40

The experience of the past decade proves that tooth wear occurs in an increasing number of cases in general dental practice. Tooth wear may have physical (abrasion and attrition) and/or chemical (erosion) origin. The primary physical causes are inadequate dental hygienic activities, bad oral habits or occupational harm. As for dental erosion, it is accelerated by the highly erosive foods and drinks produced and sold in the past decades, and the number of cases is also boosted by the fact that bulimia, anorexia nervosa and gastro-oesophageal reflux disease prevalence have become more common. The most important defensive factor against tooth wear is saliva, which protects teeth from the effect of acids. Tertiary dentin formation plays an important role in the protection of the pulp. Ideally, destructive and protective factors are in balance. Both an increase in the destructive forces, and the insufficiency of defense factors result in the disturbance of the equilibrium. This results in tooth-wear, which means an irreversible loss of dental hard tissue. The rehabilitation of the lost tooth material is often very difficult, irrespectively of whether it is needed because of functional or esthetic causes. For that reason, the dentist should carry out primary and secondary dental care and prevention more often, i.e. dental recall is indispensable every 4-6 months.
 ...
PMID:[Destructive and protective factors in the development of tooth-wear]. 1744 27

Acid reflux, which is the entry of acidic gastric contents into the upper gastrointestinal tract, may manifest as two clinical syndromes-gastroesophageal reflux and/or laryngopharyngeal reflux. The latter syndrome, laryngopharyngeal reflux, is associated with the symptom of hoarseness. In the literature on eating disorders, according to general articles on medical complications, case reports, review articles on reflux, and empirical research, patients with self-induced vomiting (e.g., anorexia nervosa binge-eating purging type, bulimia nervosa purging type) are at risk for acid reflux, potentially culminating in either reflux syndrome. Because of the unique voice effects encountered with laryngopharyngeal reflux, hoarseness may be an indistinct clinical indicator of an eating-disorder syndrome characterized by self-induced vomiting-particularly when present in a young female of normal weight or underweight status. Thus, hoarseness in young women may suggest an eating disorder, both in psychiatric and primary care settings.
 ...
PMID:Hoarseness: a sign of self-induced vomiting? 2319 76

Barrett's esophagus (BE) is a metaplastic lesion that may result from long-lasting gastroesophageal reflux and it is an established precursor of esophageal adenocarcinoma. There are reports of an increased prevalence of BE, and eventually esophageal adenocarcinoma, in patients with eating disorders characterized by purging behaviors like those with bulimia nervosa (BN). Among patients with eating disorders, those affected by anorexia nervosa binging purging subtype (ANBP), are behaviorally very similar to those with BN, but to our knowledge there are no data in literature about BE in patients with ANBP. We present the case of a 37-year-old female with a 20-year history of ANBP in comorbidity with bipolar disorder, who developed a BE requiring multi-specialistic intervention.
 ...
PMID:Barrett's esophagus in anorexia nervosa: a case report. 2475 36

A middle school girl started a diet; she developed an eating disorder, and was diagnosed with anorexia nervosa. Endoscopic examination revealed no esophagitis due to gastric reflux, but slackness was seen in the cardiac region. Multichannel intraluminal impedance pH monitoring revealed marked non-acidic reflux. On the basis of positive symptom index (SI) and symptom association probability (SAP) values, the patient was diagnosed with non-erosive gastroesophageal reflux. The patient was afraid to eat because of the reflux; therefore, laparoscopic reflux prevention surgery was performed. The symptoms completely disappeared after surgery, and normal oral ingestion was possible.
...
PMID:[Non-erosive gastroesophageal reflux disease in a teenager misdiagnosed as anorexia nervosa]. 2480 34

The two most clinically serious eating disorders are anorexia nervosa and bulimia nervosa. A drive for thinness and fear of fatness lead patients with anorexia nervosa either to restrict their food intake or binge-eat then purge (through self-induced vomiting and/or laxative abuse) to reduce their body weight to much less than the normal range. A drive for thinness leads patients with bulimia nervosa to binge-eat then purge but fail to reduce their body weight. Patients with eating disorders present with various gastrointestinal disturbances such as postprandial fullness, abdominal distention, abdominal pain, gastric distension, and early satiety, with altered esophageal motility sometimes seen in patients with anorexia nervosa. Other common conditions noted in patients with eating disorders are postprandial distress syndrome, superior mesenteric artery syndrome, irritable bowel syndrome, and functional constipation. Binge eating may cause acute gastric dilatation and gastric perforation, while self-induced vomiting can lead to dental caries, salivary gland enlargement, gastroesophageal reflux disease, and electrolyte imbalance. Laxative abuse can cause dehydration and electrolyte imbalance. Vomiting and/or laxative abuse can cause hypokalemia, which carries a risk of fatal arrhythmia. Careful assessment and intensive treatment of patients with eating disorders is needed because gastrointestinal symptoms/disorders can progress to a critical condition.
 ...
PMID:Gastrointestinal symptoms and disorders in patients with eating disorders. 2649 70

During the last decades, an increasingly greater interest in dental erosion has been observed in clinical dental practice, in dental public health and in dental research because prevalence of erosive tooth wear is still increasing especially in young age group of population. Erosive tooth wear is a multifactorial etiology process characterized by progressive loss of hard dental tissue. It is defined as the exogenous and/or endogenous acids dissolution of the dental tissue, without bacterial involvement. In the development of dental erosive wear, interactions are required which include chemical, biological, behavioral, diet, time, socioeconomic, knowledge, education, and general health factors. Examples of risk groups could be patients with eating disorders, like anorexia nervosa or bulimia nervosa, gastroesophageal reflux disease, chronic alcohol abuse or dependence. Special nutrition habits groups with high consumption of soft or sport drinks, special diets like vegetarian, vegan or raw food diet, the regular intake of drugs, medications and food supplements can also increase the risk for dental erosion. Comprehensive knowledge of the different risk and protective factors is a perquisite for initiating adequate preventive measures.
 ...
PMID:[Tooth erosion - a multidisciplinary approach]. 2700 Aug 9