Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017160 (gastroenteritis)
 11,398 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Gastroenteritis and food poisoning caused by several Salmonella serotypes are frequently observed in many countries. In particular, S. typhimurium has been found ranking first that put forward the question whether S. typhimurium can be characterized by distinct biological properties. In this paper attempts to characterized 378 Salmonella strains according to their enterotoxigenicity by means of the vascular permeability factor (PF) have been summarized. PF-positive strains are common among all Enteritis-Salmonellae, in particular among S. typhimurium. This serotype is also found with quantitative strongest PF activity. PF-positive strains are found to be active producers of exo-enterotoxins, which have been characterized as LT-enterotoxins by other assays, too. Since the capacity of Enteritis-Salmonellae to produce enterotoxins is in accordance with their clinical and epidemiological importance, the determination of the PF-factor as a rapid screening assay for enterotoxigenicity is proposed in this paper in order to survey epidemiological and clinical significant Salmonellae.
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PMID:Enterotoxigenicity among salmonellae--a prospective analysis for a surveillance programme. 34 70

In a total of 720 faecal specimens from patients with secretory diarrhoea, vomiting, dehydration, gastroenteritis, cholera and cholera like illnesses, 18 strains of V. mimicus were isolated as pure culture. These were characterized for various toxin types and virulence factors using conventional in vitro and in vivo assays. Labile and stable toxins were elaborated by 15 and 2 strains respectively by ligated rabbit ileal loop (RIL) and suckling mouse assays. While 15 of the whole cell culture elaborated labile toxin, only 7 strains produced the same when culture filtrate was tested in RIL assay. Culture filtrates of 15 strains exhibited vascular permeability factor (PF) on adult rabbit skin, none of the strains were invasive as indicated by Sereny's test. Culture supernatants of all strains produced a cytotoxic factor to Vero and Chinese hamster ovary cells. Four of the 18 strains (22%) were resistant to multiple drugs (a combination of 3 or more drugs). The results emphasize the significance of continuous screening and identification of V. mimicus and to include in the differential diagnosis of patients with acute diarrhoea.
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PMID:Toxigenicity & drug sensitivity of Vibrio mimicus isolated from patients with diarrhoea. 899 33