Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017160 (
gastroenteritis
)
11,398
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The pandemic COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and it is spreading very rapidly worldwide. To date, the origin and intermediate hosts of SARS-CoV-2 remain unclear. In this study, we conducted comparative analysis among SARS-CoV-2 and non-SARS-CoV-2 coronavirus strains to elucidate their phylogenetic relationships. We found: 1, the SARS-CoV-2 strains analyzed could be divided into 3 clades with regional aggregation; 2, the non-SARS-CoV-2 common coronaviruses that infect humans or other organisms to cause respiratory syndrome and epizootic catarrhal
gastroenteritis
could also be divided into 3 clades; 3, the hosts of the common coronaviruses closest to SARS-CoV-2 were
Apodemus chevrieri
(a rodent),
Delphinapterus leucas
(beluga whale),
Hypsugo savii
(bat) ,
Camelus bactrianus
(camel) and
Mustela vison
(mink); and 4, the gene sequences of the receptor
ACE2
from different hosts could also be divided into 3 clades. The
ACE2
gene sequences closest to that of humans in evolution include those from
Nannospalax galili
(Upper Galilee mountains blind mole rat),
Phyllostomus discolor
(pale spear-nosed bat),
Mus musculus
(house mouse),
Delphinapterus leucas
(beluga whale), and
Catharus ustulatus
(Swainson's thrush). We conclude that SARS-CoV-2 may have evolved from a distant common ancestor with the common coronaviruses but not a branch of any of them, implying that the prevalent pandemic COVID-19 agent SARS-CoV-2 may have existed in a yet to be identified primary host for a long time.
...
PMID:Comparative analysis of SARS-CoV-2 and its receptor ACE2 with evolutionarily related coronaviruses. 3318 21
