Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017160 (gastroenteritis)
 11,398 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

On occasion of an epidemic of acute nonbacterial gastroenteritis virus particles were visualized by electronmicroscopy in the faeces of 76 newborns; these particles had the following properties: mean diameter 28 nm; ether-resistent, stable at pH 3.0; buoyant density 1.33--1.34 g/ml in CsCl. About 10% of these particles had a definite star-like structure on their surface. Due to these properties the virusparticles were considered to be astroviruses. The virus was not cytopathogenic for cell cultures susceptible for enteroviruses, and not pathogenic for newborn mice.
Zentralbl Bakteriol Orig A 1978 Dec
PMID:[Visualization by electronmicroscopy of 28 nm virusparticles (astroviruses) in faeces of newborns with acute nonbacterial gastroenteritis (author's transl)]. 3 52

Methanol precipitation of transmissible gastroenteritis virus was tested at Ph 4.0, 5.0, 6.0, and 7.0 and at methanol concentrations of 15%, 25%, and 30%. Supernatant and precipitate fractions were tested for complement-fixing and agar-diffusion soluble antigens and plaque-forming units, and were examined by electron microscopy. Virus could be obtained free of detectable agar-diffusion antigens and most of the complement-fixing antigens. Most of the virions were without peplomers after methanol treatment but they retained infectivity.
Am J Vet Res 1979 Dec
PMID:Methanol precipitation of transmissible gastroenteritis virus. 4 7

61 Boston children aged five years or less with acute diarrhoea were studied for evidence of infection with Escherichia coli strains that produce heat-labile enterotoxin (L.T.) or with a reovirus-like agent associated with childhood gastroenteritis. This represented the first evaluation of the prevalence of disease produced by these two agents in the same population. E. coli, isolated from acute-phase stool specimens, were tested in adrenal-cell tissue-culture and adult-rabbit ileal-loop assays for L.T. Acute and convalescent phase sera, collected from 31 children, were tested by the adrenal-cell assay for anti-L.T. activity. None of the 61 children demonstrated evidence of infection with L.T.-positive E. coli. Paired sera from 31 of the children studied were also tested for evidence of recent infection with the reovirus-like agent by determining titres of immunofluorescent-staining antibody to the serologically related Nebraska calf diarrhoea virus. 11 of the children (35%) had evidence of recent infection. These results suggest that an important proportion of endemic acute diarrhoea of young children in Boston is caused by the reovirus-like agent, and that disease caused by L.T.-producing E. coli is uncommon.
Lancet 1975 Dec 06
PMID:Role of heat-labile toxigenic Escherichia coli and Reovirus-like agent in diarrhoea in Boston children. 5

An 8 month old infant, who died of severe gastroenteritis, presented a degeneration of the cerebellar cortex involving cells arising from the outer granular layer as well as Purkinje and Golgi II cells. Residual Purkinje cells showed vacuolar change of the cell body and dendritic abnormalities. Related lesions were atrophy of the inferior olives and degeneration of the mossy fibers.
J Neurol 1978 Dec 07
PMID:Early degeneration of the cerebellar cortex, particularly the granular cells. 8 61

Clinical signs of transmissible gastroenteritis were not observed in newborn pigs orally inoculated with the high-passaged vaccinal transmissible gastroenteritis virus (TO-163 strain). Vaccinal viral multiplication in digestive tract of newborn pigs fed colostrum before inoculation and kept at 21 to 22 C was diminished, but was not diminished in those fed colostrum and kept at 10 to 11 C. Other groups of newborn pigs inoculated with the attenuated vaccinal virus and kept at 18 to 22 C or at 31 to 34 C were challenge exposed with virulent intestinal virus on the 1st, 2nd, . . ., or 6th postinoculation (PI) days. In the groups kept at 18 to 22 C, 2 of 7 inoculated pigs challenge exposed with virulent virus on the 3rd PI day, 4 of 7 pigs exposed on the 4th PI day, and all of the pigs exposed on and after the 5th PI day survived the exposure. In the groups kept at 18 to 22 C, the attenuated vaccinal virus was distributed mainly in the respiratory organs and lymphatic tissues. On the contrary, in the groups kept at 31 to 34 C, all of the pigs died in 2 to 5 days after challenge exposure, and the attenuated vaccinal virus was scarcely detected in any of the pigs.
Am J Vet Res 1976 Dec
PMID:Vaccination of newborn pigs with an attenuated strain of transmissible gastroenteritis virus. 18 88

An in vitro leukocyte-aggregation assay was developed to detect the exposure of swine to transmissible gastroenteritis virus. Leukocytes in heparinized blood samples aggregated when mixed with test antigen prepared from transmissible gastroenteritis-infected swine testicle cell cultures. Twenty-two of 23 swine exposed 3 days or more were positive or suspects in the assay; 6 nonexposed swine were negative. Aggregation was shown as early as 3 days postexposure in 1 sow and persisted for as long as 14 months in another. Persistence of the assay was proved by repeated evaluations on 2 experimentally exposed swine.
Am J Vet Res 1976 Dec
PMID:Leukocyte-aggregation assay for transmissible gastroenteritis of swine. 18 89

Three hundred and fifty-seven sera selected at random from hospital patients of all ages were examined for rotavirus antibodies using indirect immunofluorescence (FA) and complement fixation levels (CFT). Three hundred and fourteen of these were also tested for neutralizing antibodies to human rotavirus. Sera from patients admitted with a diagnosis of acute gastroenteritis were excluded from this survey. FA antibodies were found in newborn infants but fell to undetectable titres at 3 months. The highest titres were found in children between the ages of one and three years. In older age groups, the model titre fell gradually with increasing age until, in sera from those above 70 years of age, FA antibodies were almost undetectable. The same pattern was observed with neutralizing antibodies. A high model titre of CF antibodies was only found in sera from those aged one to three years.
J Hyg (Lond) 1977 Dec
PMID:Distribution and titres of rotavirus antibodies in different age groups. 20 Jun 76

We had an outbreak of acute infantile gastroenteritis accompanied by milky-white stool (called Hakuri in Japanese) during the winters of 1976 and 1977. Stool specimens collected from 72 cases of Hakuri were studied by negative-staining electron microscopy. Rotavirus was detected with a very high frequency (89%). Rotavirus obtained from one of the patients was isolated and passaged in cultures of primary human embryonic kidney cells. Viral antigens could be detected in the cytoplasm of the cells by indirect immuno-fluorescence. The fluorescence-positive cells increased in number with repeated passage. Serum anti-viral activities in 11 patients were titrated by indirect immuno-fluorescence, using the cells infected with the passaged rotavirus. All 11 patients developed IgM responses in the convalescent phase. However, in 4 of the 11 patients, no IgG responses were detected even 2--3 weeks after the onset of illness. The reinfection which has occasionally be seen in our country may be related to these poor IgG responses.
Eur J Pediatr 1978 Dec 01
PMID:Acute infantile gastroenteritis caused by rotavirus in Japan. 21 5

Children repeatedly admitted to a Jamaican clinic with gastroenteritis associated with protein-energy-malnutrition (PEM) were treated by oral glucose-electrolyte rehydration. Children were fed other food from the outset if they so requested. The solution was administer by cup and spoon, i.e., small amounts vs. bottle administration, frequently throughout the day and night. A simple solution, very inexpensive, is outlined and includes a 3-finger pinch of salt, a 3-finger pinch of sodium bicarbonate, and 2 teaspoons of potassium chloride dissolved in 100 cu. cm of water. In all, 16 children suffering from sporadic, unspecific diarrhea over a period of 9 months showed marked improvement of the condition within 1-2 days of cup and spoon rehydration.
J Trop Pediatr Environ Child Health 1977 Dec
PMID:Cup and spoon rehydration of children with acute diarrhoea. 24 5

During a 21-month period from April 1974 to February 1976, 948 children with gastroenteritis were studied. Aetiologic agents were identified in 43% of these patients. Isolates were identified as follows: V. cholera El Tor, 273 (67%); Salmonella enteritidis, 64 (16%); enteropathogenic E. coli, 28 (7%); Shigella, 28 (7%); Vibrio (NAG), 9 (2%): and V. parahaemolyticus, 7,2%). Gastroenteritis with dehydration is a serious continuing pediatric problem in Jakarta, constituting 30% of admissions to Sumber Waras hospital. The incidence of both cholera and salmonellosis increased during the past 2 years, as judged by the distribution of enteric bacteria isolated from the rectal swabs of gastroenteritis patients in Sumber Waras hospital.
Southeast Asian J Trop Med Public Health 1977 Dec
PMID:Diarrhoeal disorders of bacterial origin in Jakarta. 35 19


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