Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0017160 (gastroenteritis)
 11,398 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty first-season Holstein crossbred calves were used in a study conducted to investigate the efficacy of two strategic treatments with doramectin (s.c. 200 micrograms kg-1 bodyweight). They were allocated in two equal groups: Group D was treated with doramectin at turn-out and 8 weeks later and Group C served as control group. Tracers were used at turn-out, in August and before housing. At monthly intervals all principal animals were weighed, and their faeces were sampled for faecal egg counts and cultured for larval identification. Serum samples were collected for determination of pepsinogen. Animals were slaughtered for worm counts 3 weeks after housing. Clinical signs of parasitic gastroenteritis (PGE) in Group C necessitated a salvage treatment with pyrantel citrate. No signs of PGE were seen in Group D. The faecal egg output remained very low (less than 50 eggs g-1) in Group D, whereas in Group C a mean geometric maximum of 352 eggs g-1 was observed. Pepsinogen levels were below 2000 mU tyrosine in Group D, compared with maximum levels of 4190 mU tyrosine in Group C. The worm counts of the tracers at housing showed an overall reduction of 94% in the total number of gastrointestinal nematodes present on the D pasture, compared with the C pasture. Worm counts of the principal animals showed an 87.8% reduction in the total worm burden. The present results show clearly that doramectin given at turn-out and at Week 8 controls PGE in calves during the first grazing season.
 ...
PMID:Control of gastrointestinal nematodes in first-season grazing calves by two strategic treatments with doramectin. 767 98

The influence of chemoprophylaxis on the immune response to gastrointestinal nematodes was evaluated in three groups of ten first-season grazing calves. Group C functioned as untreated controls, whereas Group L received two treatments, one at turn-out and one 8 weeks later, with doramectin (200 micrograms kg-1) and Group H three treatments, 3, 8, and 13 weeks post turn-out, with ivermectin (200 micrograms kg-1). At housing, five calves of each group were randomly selected for necropsied for worm counts. The remaining calves were challenged with 50,000 Ostertagi and 100,000 Cooperia oncophora and necropsied 4 weeks later. During the grazing season, Group C suffered from an outbreak of parasitic gastroenteritis which necessitated two anthelmintic treatments. In both treated groups no clinical symptoms were observed and growth rates were normal. Pepsinogen levels and antibody concentrations indicated a moderate and low gastrointestinal nematode infection in Group L and Group H, respectively. The Ostertagia and Cooperia worm populations present in the calves necropsied at housing were reduced in both treated groups in comparison with Group C. In the challenged calves, egg output was significantly higher in Group H than in Group L and Group C. Ostertagia and Cooperia worm burdens after challenge were high in Group H, moderate to low in Group L and low in Group C. This study indicates that highly suppressive prophylactic programmes, such as the ivermectin 3, 8 and 13 weeks schedule, can impair immune development against gastrointestinal nematodes during the first grazing season.
 ...
PMID:Effect of chemoprophylaxis with avermectins on the immune response to gastrointestinal nematodes in first-season grazing calves. 767 99

In this paper the different options for the diagnosis of gastrointestinal nematode infections are discussed. Diagnostic tests have a role in confirming the clinical diagnosis of parasitic gastroenteritis, but are more important for herd health monitoring of nematode infections, in particular for cattle. Therefore, emphasis is placed on discussing the available diagnostic parameters on their usefulness for that purpose. For clinical diagnosis the clinical signs, combined with the history of the animals is usually sufficient and a laboratory confirmation is not required. Faecal egg counts are, with two exceptions, not suitable for confirmation of the clinical diagnosis, because correlation between faecal egg counts and infection levels is usually low. These exceptions are the diagnosis of haemonchosis in small ruminants and the detection of anthelmintic resistance. This also limits the value of DNA-based tests of faecal material; even quantitative tests of nematode species specific DNA will have little value for diagnosis and monitoring. Pasture larval counts and worm counts are useful parameters for basic epidemiological studies on nematode infections. However, they are too laborious to be used for either routine diagnosis or monitoring. Blood parameters, such as gastrin and pepsinogen and serology are valuable tools for diagnosis. Pepsinogen and ELISAs based on recombinant proteins show most promise as parameters for herd health monitoring. However, extensive epidemiological studies are still needed before these parameters can be implemented in routine herd health monitoring schemes for parasitic gastroenteritis.
 ...
PMID:Value of present diagnostic methods for gastrointestinal nematode infections in ruminants. 1087 14