Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017160 (gastroenteritis)
 11,398 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The mean serum aldosterone concentration of 37 infants with acute gastroenteritis and dehydration was markedly elevated on admission (mean +/- SE 94.3 +/- 12.1 ng/ml) and approximated to normal values (18.2 +/- 3.7 ng/ml) following recovery from the acute disease (t=3.56 p less than 0.005). Serum aldosterone levels were significantly positively correlated with the percent weight loss (r=0.41, p less than 0.05) and with the blood urea nitrogen levels (r=0.55, p less than 0.001). There was no correlation between either serum sodium levels or blood osmolarity and aldosterone concentrations. Serum potassium levels were positively correlated with aldosterone levels (r=0.53, p less than 0.001). These findings indicate that small infants when dehydrated respond appropriately with elevated aldosterone levels. The amount of body fluid depletion and hyperkalemia are the major factors determining the amount of aldosterone response.
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PMID:Aldosterone concentrations in dehydrated infants. 670 40

Intraluminal perfusion with Escherichia coli heat-stable enterotoxin (ST) reversed water and electrolyte movements from net absorption to net secretion in porcine jejunal segments. Addition of berberine hydrochloride (3.2 X 10(-5) M) to the perfusate reduced the jejunal secretory response of water, sodium, potassium, and chloride to ST and enhanced water and electrolyte absorption in control segments. At lower concentrations (1.1 X 10(-5) M), berberine reduced the secretory response in ST-exposed segments, but only the decrease of sodium flux was significant. In the presence of berberine, the mucosal enzyme activities of adenosine triphosphatase and disaccharidases were not significantly different between control and ST-exposed segments. Doses of 1, 2, 3, 4, 5, and 10 mg of berberine were injected into ligated loops of proximal part of the jejunum with 1 ml of ST filtrate. At doses of 2 or more mg/loop, berberine was effective in reducing water and electrolyte secretions induced by ST; the effect was dose-dependent. These findings indicate that berberine may be an effective antidiarrheal agent in E coli heat-stable enterotoxin mediated secretory diarrhea and provide a basis for the frequent empirical use of berberine alkaloid and berberine-containing plants in gastroenteritis and infectious diarrhea in Asian and other countries.
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PMID:Effect of berberine on intestinal secretion mediated by Escherichia coli heat-stable enterotoxin in jejunum of pigs. 675 29

Hyperglycemia and glucosuria are frequently seen during the acute phase of dehydration secondary to gastroenteritis. In this paper, 33 patients in hypovolemic shock due to diarrhea were studied. Serum glucose resulted above 140 mg/100 ml. in 14 patients (41%); it was below 27 mg/100 ml. in 2 more patients (5.8%). Despite high glucose concentration, only 4 out of the 14 hyperglycemic patients had serum insulin concentration above that observed in normal fasting children. Plasma cortisol was significantly higher in the group with hyperglycemia (54 +/- 24 micrograms/100 ml.) in comparison with the group with normal glucose levels (15 +/- 6.4 micrograms/100). No correlation was found between serum glucose and the concentrations of sodium, potassium, bicarbonate, growth hormone nor with plasma osmolarity. All disturbances observed turned normal after rehydration. Hyperglicemia is explained as a response to stress and is probably due to the gluconeogenic action of cortisol and the inhibitory effect of catecholamines upon insulin secretion.
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PMID:[Hyperglycemia of the dehydrated infant]. 699 Sep 40

Alternate cases of infantile gastroenteritis (IGE) admitted to the Department of Pediatrics, National University of Singapore, were put on rice water (RW) or the standard World Health Organization oralyte solution (WOS) to compare the effect of oral RW to WOS. On admission, each patient's hydration status was assessed. Serum electrolytes were taken before any treatment was initiated. Milk was totally withdrawn for 24 hours, or longer, as the situation demanded. Those who needed intravenous fluid hydration were dripped accordingly for 24 hours usually and then the oral fluids (RW or WOS) were given depending on the protocol. There were 63 patients on WOS and 67 on RW. All recovered fully, and there were no deaths nor any sequelae from the episode of gastroenteritis. The compability of the 2 groups was assessed in terms of the age groups, sex, race, number of days of diarrhea before admission, degree of dehydration, and the electrolytes prior to treatment. There were no statistical differences between the serum sodium (Na), chloride (Cl), urea, potassium (K), and bicarbonate (HCO3) in the 2 groups. The 2 groups were comparable. After each group had been treated with WOS or RW, the serum electrolytes were repeated on day 3 to see if there were any differences in the results. The only statistically significant difference was between C and H, i.e., in the WOS group the serum urea was lower in those with intravenous drip, between N and S, i.e., in the RW group. Babies on rice water passed fewer stools/day compared to those on WOS. The most important finding from this controlled trial with WOS and RW in the management of IGE was the effectiveness of RW in reducing the frequency of stools and hence faster rehydration compared to WOS. The 2 groups were eminently comparable, yet RW was as effective or even more effective than WOS in controlling the diarrhea. It is recommended that in the Singapore context rice water is a convenient, sterile, and effective antidiarrheal agent.
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PMID:Gastroenteritis: III. Rice-water in the management of infantile gastroenteritis in Singapore. 705 47

Sodium, potassium and magnesium were measured in serum resp. plasma and in erythrocytes of oliguricanuric children with acute haemolytic uraemic syndrome (HUS). Potassium was in serum resp. plasma and in red cells in normal range or decrease compared with other forms of acute renal failure in children. These findings were different to statements in the relevant literature, which describe hyperkaliaemia. We suppose a potassium depletion in the early state of HUS. The cause is still unknown. Furthermore we found a hyponatriaemia according to severity of edema and gastroenteritis. Sodium in red cells and magnesium in plasma and erythrocytes were slightly elevated.
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PMID:[Pattern of serum and red cell electrolytes in acute haemolytic uraemic syndrome (author's transl)]. 719 93

Electrolyte disturbances and response to oral electrolyte therapy were studied in 88 children with mild to moderate dehydration due to acute gastroenteritis. A solution with a sodium concentration of 50 mmol/litre was tested in a group of 60 children and results obtained with those in a group of 28 children taking a standard oral solution with a concentration of 90 mmol/litre. Adequate hydration was accomplished in both groups and none of them received intravenous fluids. Neither group received additional water or other fluid in the first 24 hours. There was a significant rise in sodium concentration with both solutions and none of the children developed hypernatraemia. A significant rise in potassium is observed in children with clinical kwashiorkor when hydrated with the low sodium solution.
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PMID:Oral rehydration for diarrhoeal diseases in children. 732 31

Broad spectrum antibiotics are known to predispose towards oral candidiasis and gastroenteritis. Oral nitrite synthesis by commensal bacteria may be important in protecting the mouth and lower intestine from pathogenic organisms, including Candida albicans. The effect of 2 days administration of the broad spectrum antibiotic amoxycillin on salivary nitrite concentration, following a 200 mg potassium nitrate oral load, was studied in 10 healthy volunteers. The Cmax fell by 40% and the AUC was reduced by 1227 microM h (43%, 95% CI 273, 2181, P < 0.006) in the antibiotic treated group when compared with control. These findings suggest that destruction of nitrate reductase containing bacteria in the mouth by antibiotics may explain an increased incidence of infection with Candida and other pathogens.
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PMID:The effect of amoxycillin on salivary nitrite concentrations: an important mechanism of adverse reactions? 764 Jan 57

Thallium (Tl) is one of the most toxic of the heavy metals. Its continued use as a rodenticide in many developing countries and its increasing use in an expanding number of new technologies raise concerns about exposure risk to animals and humans. Because Tl and potassium (K) have the same charge and similar ionic radii, Tl follows K distribution pathways and alters and number of K-dependent processes. Possible toxic mechanisms of Tl include ligand formation with protein sulfhydryl groups, inhibition of cellular respiration, interaction with riboflavin and riboflavin-based cofactors, and disruption of calcium homeostasis. The principal clinical features of thallotoxicosis are gastroenteritis, peripheral neuropathy of unknown etiology, and alopecia. The presence of elevated Tl levels in the urine or other biologic materials confirms the diagnosis of Tl poisoning. Treatment with prussian blue (or activated charcoal) will interrupt the enterohepatic cycling of Tl, thus enhancing fecal elimination of the metal. Forced diuresis with potassium loading will increase the renal clearance of Tl, but should be used cautiously because neurologic and cardiovascular symptom may be exacerbated. If recognized and treated early, Tl poisoning carries a favorable prognosis for full recovery.
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PMID:A review of thallium toxicity. 824 71

Hypokalemic periodic paralysis is a condition, characterized by episodic weakness of the skeletal muscle. It may be presented as familial or sporadic (secondary). In sporadic cases, the patient may present with paralysis without any previous self or familial history. It is known that these patients are more susceptible to hypokalemia than normal individuals. In low serum K+ concentrations that the normal population can tolerate, these patients may easily suffer from paralysis. A sporadic case of hypokalemic quadriparesis associated with acute gastroenteritis without any self or family history is reported. The patient had experienced two episodes of quadriparesis within a short interval and responded dramatically to potassium replacement therapy.
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PMID:Hypokalemic paralysis in association with acute gastroenteritis: a report of a sporadic case. 958 5

Of 68 patients who were admitted with acute quadriparesis to a hospital in northern India, over 70% were found to be hypokalaemic. The most common cause of hypokalaemia was that associated with gastroenteritis (54%). These patients had all received intravenous fluids previously. It is likely that their hypokalaemia was caused by gastrointestinal loss compounded by parenteral fluid replacement. The next most common group of hypokalaemia-associated quadriparesis had no obvious cause for hypokalaemia (38%). Hypokalaemia-induced quadriparesis is a potentially life-threatening illness which can be readily treated with potassium supplements. The physician should consider hypokalaemia in patients who present with acute onset quadriparesis, and even if diagnostic tests for hypokalaemia are not available, should consider a judicious trial of potassium supplementation empirically, provided that there are no contraindications.
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PMID:Preponderance of hypokalaemia as a cause of acute onset quadriparesis in northern India/southern Nepal. 1044 37


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