Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017160 (gastroenteritis)
 11,398 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During the period from April 1992 to April 1993 at the Clinic for infectious Disease in Sarajevo were hospitalized 213 patients. The major causative agents were different kinds of Shigella. Shigella sonnei with 159 (74.6%) was the most frequent isolated organism, then subsequent Shigella species with 38 (23.9%) and Shigella flexneri 3 with 23 (14.5%). Bacillary dysentery (Shigellosis) was manifested as acute gastroenteritis with 60 patients (37.7%). This disease was manifested in the form of acute enterocolitis in the same number and there were also 39 cases or 24.5% of enterocolitis acuta haemorrhagica. The patients were treated with symptomatic or dietary regimen in 69 (43.4%). As a specific therapy 36 (22.6%) patients were received Trimethoprim-sulfamethoxazole, 28 (17.6%) Chloramphenicol and 24 (15.1%) Pefloxacin, 56 patients were treated with Nifuroxazid (Ercefuryl) only. The most sensitivity of isolated organism were shown up against Pefloxacin (100%), aminoglycosides (99.4%), Chloramphenicol (96.9%) and Cephalosporins (60.4%). The lowest sensitivity, at the same rate had Ampicillin and Trimethoprim sulfamethoxazole. All patients were recovered, there were no complications. The diseases were manifested as acute gastroenterocolitis (28 or 13.1%), and acute enterocolitis (17 or 8.0%) at the patients with bacteriological unknown causative agents. Salmonella was recorded at 9 patients.
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PMID:[Diarrheal disease in hospitalized patients during the first year of the war]. 796 96

Resistance patterns, plasmid profiles and the genetic resistance determinants were investigated in 38 isolates of Salmonella enterica serotype Typhimurium and 19 isolates of Salmonella enterica serovar Enteritidis derived from children hospitalized in two clinics in Cluj-Napoca, during the period of 1995-1997. Incidence of plasmid and antibiotic resistance was very high in Salmonella typhimurium isolates. All strains were resistant to almost all antibiotics tested but susceptible to the third generation cephalosporines and fluoroquinolones. We identified three resistance patterns and six plasmid profiles. Each plasmid profile was characterized by the presence of two large plasmids of 150-180 Kbp. Approximately 60% of strains harbored three or four small plasmids of 1.3 to 9.5 Kbp. The plasmids of 8.5 Kbp encoded resistance to beta-lactam antibiotics and were non-conjugative. The other small plasmids were cryptic and also non-conjugative. Salmonella enteritidis isolates were susceptible to many antibiotics, except Tetracycline and Trimethoprim-Sulfamethoxazole. We identified three different resistance patterns but nine plasmid profiles. All plasmid profiles were characterized by the presence of a large plasmid (> 100 Kbp). The number and the diversity of small plasmids were higher than in S. typhimurium strains. There was no parallelism between resistance and plasmid profile: for the same resistance pattern a number of two or three plasmid profiles were found. Our conclusions are that Salmonella typhimurium strains were multiresistant to antibiotics and that many genetically different strains of Salmonella typhimurium and Salmonella enteritidis were responsible for gastroenteritis in children from Cluj County. The increasing antibiotic resistance highlights the need for more refined methods in genetic and epidemiological characterization of bacteria involved in gastrointestinal infections.
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PMID:Plasmid profile analysis and antibiotic resistance of Salmonella strains from clinical isolates in Cluj-Napoca. 974 25