Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017160 (gastroenteritis)
 11,398 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The study was performed on 20 piglets of both sexes. The control group consisted of 10 healthy piglets, the experimental, group included 10 piglets with symptoms of gastroenteritis. All the animals were subjected to euthanasia at the age of 21 or 35 days (weaning), or 7 days after weaning, and immunohistochemical and histopathological examinations were performed on all of them. Immunohistochemical examinations of the experimental piglets included additional tests made on five piglets with gastroenteritis, characterized by poor general condition. Histopathological examinations of the pancreas revealed retrogressive changes, which might result from hemodynamic disorders. Changes in the localization of SOM and VIP found in the pancreas suggested inhibition of pancreatic enzyme synthesis in piglets with diarrhea. The co-localization of GAL and dopamine beta-hydroxylase (D beta H--a key enzyme of the noradrenaline synthesis pathway) in perivascular nerve fibers could lead to considerable vasospasms in the pancreas, resulting in deeper hypoxia of the organ. Immunohistochemical and histopathological examinations confirmed the results of biochemical analyses, indicating failure of the pancreatic exocrine function in piglets with gastroenteritis.
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PMID:Effect of metabolic disorders accompanying gastroenteritis on the pancreatic exocrine function in piglets. C. Histopathological and immunohistochemical changes in the pancreas of piglets with gastroenteritis. 1244 81

A 62-year-old male died of colchicine poisoning after accidental ingestion of Colchicum autumnale (meadow saffron). He ate a salad of plant with green leaves regarded as wild garlic (Allium ursinum). A few hours later he developed symptoms of gastroenteritis and was admitted to hospital. In spite of gastric lavage, activated charcoal and supportive measures, multi-organ system failure developed over the next two days. Laboratory analysis showed highly elevated blood concentrations of hepatic enzymes, creatine kinase, lactate dehydrogenase and blood urea nitrogen, as well as leukocytopenia and thrombocytopenia. Mechanical ventilation, dopamine, noradrenaline, crystalloid solutions and fresh frozen plasma were applied but despite treatment the patient died five days after the ingestion. Post-mortem examination revealed hepatic centrilobular necrosis, nephrotoxic acute tubular necrosis, petechial bleeding in fatty tissue, blunt and shortened intestinal villi and cerebral toxic edema. Botanical identification of incriminated plant gave Colchicum autumnale which confirmed colchicine poisoning. Although the accidental ingestion of Colchicum autumnale is rare and to our knowledge only five such cases have been described in detail, this is the second fatal case in Croatia described in the last 3 years.
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PMID:Fatal colchicine poisoning by accidental ingestion of meadow saffron-case report. 1574 68