Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0017160 (
gastroenteritis
)
11,398
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Today, an alarming rise of bacterial
gastroenteritis
in humans resulting from consuming
Campylobacter
-tainted foods is being observed. One of the solutions for mitigating this issue may be the antibacterial activity of essential oils. In the present research, we propose to study the antibacterial activity against
Campylobacter
and other Gram-negative bacteria of
Daucus carota
essential oil and its active molecules. In addition, a few chemically synthesized molecules such as (
E
)-methylisoeugenol,
Elemicin
, and eugenol were also studied. The results showed that the essential oil itself and its most active component, (
E
)-methylisoeugenol, exhibited bactericidal effects. Similar effects were detected using purified and chemically synthesized molecules. Also, it was observed that the
Daucus carota
essential oil and its active molecules affected intracellular potassium and intracellular ATP contents in
Campylobacter
cells. Inhibition of the membrane bound F
O
F
1
-ATPase was also observed. Eventually, for the first time, the efflux mechanism of active molecules of
Daucus carota
essential oil was also identified in gamma proteobacteria and its specific antibacterial activity against
Campylobacter jejuni
was associated with the lack of this efflux mechanism in this species.
...
PMID:Antibacterial Mode of Action of the
Daucus carota
Essential Oil Active Compounds against
Campylobacter jejuni
and Efflux-Mediated Drug Resistance in Gram-Negative Bacteria. 3323 54
