Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017160 (gastroenteritis)
 11,398 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Random fecal alpha-1-antitrypsin concentration was measured in children with various gastrointestinal diseases and in normal subjects. One hundred fifteen subjects were evaluated: controls (39); chronic inflammatory bowel disease (20); chronic diarrhea (18); acute gastroenteritis (17); allergic gastroenteropathy (5); chronic pancreatic exocrine insufficiency (4); acute gastrointestinal bleeding (4); nonspecific colitis (4); celiac disease (3); and intestinal lymphangiectasia (1). Mean fecal-alpha-1-antitrypsin for the controls was 0.98 mg/g lyophilized stool. All children with celiac disease, allergic gastroenteropathy, lymphangiectasia, nonspecific colitis, acute gastrointestinal bleeding, and 19 of 20 patients with active chronic inflammatory bowel disease had fecal alpha-1-antitrypsin concentrations greater than 2.6 mg/g stool (mean of the controls + 2 SD). These disorders have all been previously documented to cause protein-losing enteropathy by 51Cr-labeled albumin excretion tests. The other study patients had normal fecal alpha-1-antitrypsin excretion when compared with controls. Serial fecal antitrypsin concentrations paralleled disease activity and clinical response to therapy. The results suggest that random fecal antitrypsin concentration is a valuable screening test for mucosal disorders associated with abnormal transmucosal serum protein loss.
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PMID:Random fecal alpha-1-antitrypsin concentration in children with gastrointestinal disease. 697 Jul 2

Antibody response and serum protein and immunoglobulin concentrations in pigs from sows fed various crude protein sequences during gestation and lactation were studied over three consecutive parities at two locations. Each sow was placed on one of the following dietary crude protein sequences during gestation/lactation: (1) 14%/14%, (2) 12%/16% or (3) 9%/18%. Pig weights were recorded and blood samples taken at 1, 28, 42 and 49 days of age. Generally, body weight gain did not differ between pigs from sows fed different protein sequences. Sow protein sequence had no apparent influence on the pigs' ability to respond to a Salmonella H antigen (1.8 x 10(10) organisms/ml) intraperitoneally injected at 28 days of age when titers were determined 14 and 21 days later. Serum protein concentrations of progeny at 1, 28 and 49 days of age were not influenced by sow protein sequence, although pigs from sows given higher protein levels during lactation tended to have higher (P less than .10) concentrations at weaning (28 days). Serum IgG, IgA and IgM concentrations were not different for pigs from sows on different protein sequences. However, during the first parity at one of the locations, serum IgG and IgA concentrations were elevated (P less than .01) in pigs in all groups, possibly because of transmissible gastroenteritis which interfered with the pig antibody response. Sow protein sequence had no effect on antibody response or serum immunoglobulin concentrations, and pigs from first-litter gilts had a reduced ability to respond to a Salmonella H antigen.
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PMID:Antibody response and serum protein and immunoglobulin concentrations in pigs from sows fed different protein sequences during gestation and lactation. 731 69

A prospective study of 90 children admitted to Ethio-Swedish Children's Hospital in Addis Ababa, Ethiopia, in 1992 with severe protein-energy malnutrition assessed the clinical profile and patterns of infection. The children, who ranged in age from 4 to 60 months, suffered from marasmus (49%), marasmic-kwashiorkor (42%), and kwashiorkor (19%). Septicemia, the most alarming complication of severe protein-energy malnutrition, was present in 32 children (36%); gram-negative enteric bacilli were the most common bacterial pathogen. 57 children (63%) had pneumonia and 23 (26%) had tuberculosis. Another 33 (37%) had a urinary tract infection. 17 children (19%) presented with diarrhea, 33 (37%) had clinical and radiologic evidence of rickets, and 15 (17%) had clinical evidence of vitamin A deficiency. There were 29 deaths in this series (from septicemia, gastroenteritis, pneumonia, and disseminated tuberculosis), for a case fatality rate of 32%. Mortality was significantly greater among children with a total serum protein of 5 gm% or less and those with systemic infection. This profile differs from those recorded in other developing countries, suggesting that severe protein-energy malnutrition has clinical and geographic heterogeneity.
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PMID:Clinical profile and pattern of infection in Ethiopian children with severe protein-energy malnutrition. 806 77