Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017160 (gastroenteritis)
 11,398 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The number of recognized infectious causes of diarrhea potentially treatable with specific antibiotics has markedly increased within the past ten years. Laboratories are developing and expanding their abilities to deal with these new pathogens. Neither prophylaxis nor specific treatment of diarrhea in travelers is simple, practical, and safe. Although enterotoxigenic Escherichia coli is the most important cause of diarrhea in U.S. travelers to tropical areas, Campylobacter jejuni causes acute diarrhea in persons in the United States about as often as do Salmonella and Shigella. Vibrio parahemolyticus is an important cause of outbreaks of gastroenteritis following ingestion of improperly cooked shellfish; Bacillus cereus is important in outbreaks of diarrhea after ingestion of improperly cooked and stored rice in Chinese restaurants. Although Yersinia enterocolitica is probably an important cause of severe enteritis in the United States, imperfect techniques for its isolation and lack of good serologic tests have hampered recognition of its importance. Practical means for diagnosing antibiotic-associated colitis and the role of Clostridium difficile toxins in this disease are now available. Vancomycin, metronidazole, bacitracin, and cholestyramine are useful in treatment of antibiotic-associated colitis.
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PMID:Recent advances in management of bacterial diarrhea. 640 74

A 34-year-old female with end-stage renal disease was admitted for severe metabolic acidosis, uremic encephalopathy, pericarditis and severe anemia following a bout of acute gastroenteritis. She improved on aggressive medical management including intensive hemodialysis and was initiated onto maintenance heparin-free hemodialysis (twelve hours per week) and discharged. After a week, she presented with fever with chills and rigors for three days, was toxic, severely orthopenic and had a pulsus paradoxus of 36 mmHg. Echocardiography suggested cardiac tamponade. Aspiration revealed frank pus with polymorphonuclear predominance and Staphylococcus aureus on culture. CT of the thorax revealed pericardial effusion. In the absence of any obvious septic foci, concomitant pleuro-pulmonary sepsis, mediastinal or intra-abdominal pathology; a diagnosis of "acute primary purulent pericarditis" was made. Patient was put on parenteral antibiotics-ceftriaxone and metrogyl. Vancomycin was added after sensitivity results. Pericardial drainage was required initially. After toxemia improved, paradox decreased and fever subsided, the pericardial catheter was removed and antibiotics continued for a period of four weeks. Maintenance hemodialysis was continued during hospital stay and after discharge.
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PMID:Staphylococcal pericarditis in a chronic renal failure patient. 1280 14

Vancomycin is a preferred antibiotic for treating Clostridium difficile infection (CDI) and has been associated with a rate of recurrence of CDI of as high as 20% in treated patients. Recent studies have suggested that berberine, an alternative medical therapy for gastroenteritis and diarrhea, exhibits several beneficial effects, including induction of anti-inflammatory responses and restoration of the intestinal barrier function. This study investigated the therapeutic effects of berberine on preventing CDI relapse and restoring the gut microbiota in a mouse model. Berberine was administered through gavage to C57BL/6 mice with established CDI-induced intestinal injury and colitis. The disease activity index (DAI), mean relative weight, histopathology scores, and levels of toxins A and B in fecal samples were measured. An Illumina sequencing-based analysis of 16S rRNA genes was used to determine the overall structural change in the microbiota in the mouse ileocecum. Berberine administration significantly promoted the restoration of the intestinal microbiota by inhibiting the expansion of members of the family Enterobacteriaceae and counteracting the side effects of vancomycin treatment. Therapy consisting of vancomycin and berberine combined prevented weight loss, improved the DAI and the histopathology scores, and effectively decreased the mortality rate. Berberine prevented CDIs from relapsing and significantly improved survival in the mouse model of CDI. Our data indicate that a combination of berberine and vancomycin is more effective than vancomycin alone for treating CDI. One of the possible mechanisms by which berberine prevents a CDI relapse is through modulation of the gut microbiota. Although this conclusion was generated in the case of the mouse model, use of the combination of vancomycin and berberine and represent a novel therapeutic approach targeting CDI.
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PMID:Berberine blocks the relapse of Clostridium difficile infection in C57BL/6 mice after standard vancomycin treatment. 2582 19