Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017160 (gastroenteritis)
 11,398 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During the period from April 1992 to April 1993 at the Clinic for infectious Disease in Sarajevo were hospitalized 213 patients. The major causative agents were different kinds of Shigella. Shigella sonnei with 159 (74.6%) was the most frequent isolated organism, then subsequent Shigella species with 38 (23.9%) and Shigella flexneri 3 with 23 (14.5%). Bacillary dysentery (Shigellosis) was manifested as acute gastroenteritis with 60 patients (37.7%). This disease was manifested in the form of acute enterocolitis in the same number and there were also 39 cases or 24.5% of enterocolitis acuta haemorrhagica. The patients were treated with symptomatic or dietary regimen in 69 (43.4%). As a specific therapy 36 (22.6%) patients were received Trimethoprim-sulfamethoxazole, 28 (17.6%) Chloramphenicol and 24 (15.1%) Pefloxacin, 56 patients were treated with Nifuroxazid (Ercefuryl) only. The most sensitivity of isolated organism were shown up against Pefloxacin (100%), aminoglycosides (99.4%), Chloramphenicol (96.9%) and Cephalosporins (60.4%). The lowest sensitivity, at the same rate had Ampicillin and Trimethoprim sulfamethoxazole. All patients were recovered, there were no complications. The diseases were manifested as acute gastroenterocolitis (28 or 13.1%), and acute enterocolitis (17 or 8.0%) at the patients with bacteriological unknown causative agents. Salmonella was recorded at 9 patients.
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PMID:[Diarrheal disease in hospitalized patients during the first year of the war]. 796 96

Increasing access to rapid diagnostic tests for malaria (mRDTs) has raised awareness of the challenges healthcare workers face in managing non-malarial febrile illnesses (NMFIs). We examined NMFI prevalence, clinical diagnoses, and prescribing practices in outpatient clinics across different malaria transmission settings in Malawi. Standardized facility-based malaria surveillance was conducted at three facilities one of every 4 weeks over 2 years. Information on demographics, presenting symptoms, temperature, clinical diagnosis, and treatment were collected from outpatients presenting with malaria-like symptoms. Of the 25,486 patients with fever, 69% had NMFI. Non-malarial febrile illness prevalence was lower in 5- to 15-year-old patients (55%) than in children < 5 years (72%) and adults > 15 years of age (77%). The most common clinical diagnoses among febrile patients with negative mRDTs in all age-groups and settings were respiratory infections (46%), sepsis (29%), gastroenteritis (13%), musculoskeletal pain (9%), and malaria (5%). Antibiotic prescribing was high in all age-groups and settings. Trimethoprim-sulfamethoxazole (40%) and amoxicillin (29%) were the most commonly prescribed antibiotics and were used for nearly all clinical diagnoses. In these settings with minimal access to diagnostic tools, patients with fever and a negative mRDT received a limited number of clinical diagnoses. Many were likely to be inaccurate and were associated with the inappropriate use of the limited range of available antibiotics. Prescription and diagnostic practices for NMFIs in the facilities require research and policy input. Resource-limited malaria-endemic countries urgently need more point-of-care diagnostic tools and evidence-based diagnosis and treatment algorithms to provide effective and cost-efficient care.
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PMID:Prevalence and Clinical Management of Non-malarial Febrile Illnesses among Outpatients in the Era of Universal Malaria Testing in Malawi. 3258 95