Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017160 (gastroenteritis)
 11,398 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 45 newly-weaned 3 to 4-week-old piglets, diarrhoea was induced by a combined infection with transmissible gastroenteritis (TGE) virus and enterotoxigenic E. coli (ETEC) strains. In untreated control animals this dual inoculation resulted in profuse diarrhoea, vomiting, hypovolaemic shock and death of 77% of the animals within five days of TGE virus inoculation. Antisecretory drugs were administered intramuscularly for three consecutive days after experimental infection. The neurolepticum chlorpromazine, at 2 mg/kg/24 h, resulted in a significant inhibition of diarrhoea and vomiting, and in an increase in weight gain and survival. Sedation and hypothermia, however, were serious side-effects. The alpha 2 agonist clonidine, at 80 micrograms/kg/12 h, induced a significant antidiarrhoeal effect and a reduction in mortality. The drug, however, provoked decreased activity of alpha 2-adrenergic excitation and incoordination. The beta-adrenergic antagonist propranolol, at 0.33 mg/kg/8 h, and the calcium channel blocker verapamil, at 2 mg/kg/8 h, had no beneficial effect on the experimentally induced diarrhoea.
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PMID:Effect of antisecretory drugs on experimentally induced weanling diarrhoea in piglets. 267 57

The rapid economic change experienced in the Arab Gulf countries in the past two decades has resulted in a dramatic decline in the number of infants breast fed and the duration of breast feeding. This survey describes the current status of breast feeding in the Arabian Gulf countries in terms of the duration of exclusive breast feeding; initiation, frequency, and duration of breast feeding; bottle feeding practices; breast feeding and fertility; reasons for cessation of breast feeding; and the relationship between breast feeding and gastroenteritis. After a brief discussion of weaning practices, the paper considers factors influencing the decision to breast feed, including mothers age, education, urban-rural residence, and employment status; the influence of house maids and health workers; and the sex of the child. The marketing of baby foods in the area is described, as are various programs to support breast feeding, such as maternity protection, educational activities, marketing activities, support of appropriate weaning practices, workshops and seminars, and research activities. It is concluded that these programs have had very little effect on the promotion of breast feeding in the region for the following reasons: 1) lack of coordination; 2) lack of health regulations covering formulas and baby foods; 3) the encouragement of bottle feeding in private hospitals; 4) insufficient knowledge of managing breast feeding among health personnel; 5) a shortage of studies relating to breast feeding; and 6) insufficient training of health personnel. The institution of a global promotional policy is recommended. Such a policy would include the development of strict regulations covering marketing of substitutes, training of health workers, mass media campaigns, school and university curricula changes, and convincing policy-makers that breast feeding is beneficial.
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PMID:Breastfeeding patterns in the Arabian Gulf countries. 749 43

The comparative effects of diazinon and malathion on Najdi sheep were described in sheep allotted as untreated controls, diazinon-treated at 25 mg/kg/d or 50 mg/kg/d, and malathion-treated at 25 mg/kg/d or 50 mg/kg/d. Although serum cholinesterase (ChE) activity was reduced, neither significant clinical signs nor severe pathological changes were produced in sheep dosed orally with 25 or 50 mg diazinon/kg/d for 21 d. Both oral dose levels of malathion were lethal to sheep between 1 and 6 d and caused, prior to death, hyperexcitability, tremors, clonic convulsions, salivation, nasal discharge, incoordination of movement, paresis of the limbs and recumbency. Lesions were widespread congestion and hemorrhage, patchy pulmonary cyanosis, gastroenteritis and hepatonephropathy. These changes were accompanied by increases in the activities of serum SDH and AST, in the concentrations of urea, triglyceride and cholesterol, and decreases in ChE activity and in RBC, PCV and Hb values.
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PMID:Comparative effects of diazinon and malathion in Najdi sheep. 1050 28