Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017160 (gastroenteritis)
 11,398 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report a case of eosinophilic gastroenterocolitis in a 2-year-old child with extensive fibrosis, atrophy of the muscularis propria and involvement of stomach, small bowel and colon. Following an attack of acute gastroenteritis at the age of 15 months the symptoms of ileus persisted. A biopsy of small bowel at the age of 18 months showed numerous eosinophilic granulocytes in the mucosa. At the age of 28 months the child died with paralytic ileus. This is the first case known to us of an eosinophilic gastroenteritis in early childhood with a fatal outcome.
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PMID:Fatal eosinophilic gastroenterocolitis in a two-year-old child. 16 Jun 65

Fourteen cases of intestinal pneumotosis were found in a review of 1 477 plain abdomen X-ray films taken because of different conditions. These 14 cases were associated in most instances with septicemia, gastroenteritis and paralytic ileus. The mortality was high. The treatment should be directed to the management of the primary condition: intestinal pneumatosis, septicemia, gastroenteritis, paralytic ileus.
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PMID:[Intestinal pneumatosis]. 87 30

Intestinal infarction was studied in 20 children with acute gastroenteritis. Eighteen cases (90%) died and 2 (10%) recovered. The disease was most frequently seen in infants under one month of age (85%) and in malnourished cases with subnormal weight at birth. It was suspected only in four patients and in the rest, it was a surgical or post mortem finding. No clinical or radiological findings were detected to orient diagnosis. The following signs are considered jointly to support a diagnostic suspicion; prolonged paralytic ileus, abdominal vascular distress, peritoneal irritation, shock and history of diarrhea. Considerations are made on its pathology, clinical picture and treatment, stressing the fact that an early surgical treatment may increase survival possibilities.
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PMID:[Intestinal infarction in the newborn]. 124 78

Oral rehydration is an ideal form of treatment of gastroenteritis in India both in large hsopitals and in rural health centers where adequate facilities and trained personnel are lacking. This paper concerns a study of oral rehydration in 30 patients (aged 17 days to 5 years) admitted to the Children's Ward (of Goa Medical College between April to August 1972) for gastroenteritis and 210 children who were treated in the Outpatients' Dept. (Ta 1). Tables 2 and 3 show the complaints on admission and clinical signs of the disorder. Fluid replacement was divided into 2 phases. Intravenous fluid thera was administered to all children admitted in shock. Rehydration was started in all cases without shock and was maintained with orally administered glucose electrolyte solution. 12 patients had severe dehydration, 9 moderate and 9 mild. Table 5 details the control of diarrhea while Table 6 details the amount oral fluids given to different age groups and to patients with varying degrees of dehydration. 2 patients (3- and 5- month old females) developed paralytic ileus that led to their deaths. Paralytic ileus is a grave complication with a high mortality rate. It can be prevented by early and adequate administration of potassium. It is possible that some of the 210 outpatients in this study had transient diarrhea, cured themselves of it or took electrolytes which prevented complications from developing. The practice of dispensing "salts" to outpatient appear promising and should be encouraged.
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PMID:Oral rehydration in gastroenteritis in children. 476 71

A case is presented of a fatal drug interaction caused by ingestion of clozapine (Clozaril) and fluoxetine (Prozac). Clozapine is a tricyclic dibenzodiazepine derivative used as an "atypical antipsychotic" in the treatment of severe paranoid schizophrenia. Fluoxetine is a selective serotonin reuptake inhibitor used for the treatment of major depression. Clinical studies have proven that concomitant administration of fluoxetine and clozapine produces increased plasma concentrations of clozapine and enhances clozapine's pharmacological effects due to suspected inhibition of clozapine metabolism by fluoxetine. Blood, gastric, and urine specimens were analyzed for fluoxetine by gas chromatography/mass spectrometry (GC/MS) and for clozapine by gas-liquid chromatography (GLC). Clozapine concentrations were: plasma, 4.9 micrograms/mL; gastric contents, 265 mg; and urine, 51.5 micrograms/mL. Fluoxetine concentrations were: blood, 0.7 microgram/mL; gastric contents, 3.7 mg; and urine 1.6 micrograms/mL. Norfluoxetine concentrations were: blood, 0.6 microgram/mL, and none detected in the gastric contents or urine. Analysis of the biological specimens for other drugs revealed the presence of ethanol (blood, 35 mg/dL; vitreous, 56 mg/dL; and urine 153 mg/dL) and caffeine (present in all specimens). The combination of these drugs produced lethal concentrations of clozapine and high therapeutic to toxic concentrations of fluoxetine. The deceased had pulmonary edema, visceral vascular congestion, paralytic ileus, gastroenteritis and eosinophilia. These conditions are associated with clozapine toxicity. The combined central nervous system, respiratory and cardiovascular depression of these drugs was sufficient to cause death. The death was determined to be a clozapine overdose due to a fatal drug interaction.
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PMID:A fatal drug interaction between clozapine and fluoxetine. 972 31

A 2-year-old girl was diagnosed as having acute gastroenteritis with severe diarrhoea, for which she was prescribed a loperamide solution. Following this she developed paralytic ileus. She was then treated conservatively and was administered fluid and electrolytes parenterally. She started to recover after 48 hours. In young children with acute diarrhoea there usually is no place for medicinal treatment, and certainly not with antimotility drugs such as loperamide.
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PMID:[Ileus after the use of loperamide in a child with acute diarrhea]. 1271 53