Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0017160 (gastroenteritis)
 11,398 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Human listeriosis is caused by the Gram-positive bacterium Listeria monocytogenes. In humans, this pathogen has the ability to cross the intestinal, placental and blood-brain barriers, leading to gastroenteritis, maternofetal infections and meningoencephalitis, respectively. The entry of L. monocytogenes into cultured human epithelial cells is mediated by the interaction of an L. monocytogenes surface protein, internalin, with its human receptor, E-cadherin. The internalin-E-cadherin interaction is species-specific, and relies on the nature of a single amino-acid in the E-cadherin molecule, which is proline in permissive species such as humans, and glutamic acid in non-permissive species such as the mouse. In a transgenic mouse model that expresses human E-cadherin in enterocytes, internalin allows L. monocytogenes to cross the intestinal barrier. Epidemiological evidence also supports a role for internalin in human listeriosis, not only for crossing the intestinal barrier, but also for targeting and crossing the placental and blood-brain barriers. Consistent with these epidemiological data, infection with L. monocytogenes of trophoblastic cell lines, primary trophoblast cultures and human placental villous explants demonstrates that bacterial invasion of the syncytiotrophoblast barrier is mediated by the internalin-E-cadherin interaction, leading to histopathological lesions that mimic those seen in the placentas of women with listeriosis. Thus, the internalin-E-cadherin interaction that plays a key role in the crossing of the intestinal barrier in humans is also exploited by L. monocytogenes to target and cross the placental barrier. Further investigations are currently focusing on the molecular mechanisms by which L. monocytogenes targets and crosses the blood-brain barrier.
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PMID:Understanding how Listeria monocytogenes targets and crosses host barriers. 1588 92

A 75-year-old man, with a long history of recurrent lymphoplasmacytoid lymphoma, presented with diffuse large-cell lymphoma affecting adrenal glands and causing severe hypoadrenalism. The lymphoma responded to rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) chemotherapy. Seven months postcompletion of chemotherapy, he developed signs of gastroenteritis and septicaemia. He deteriorated 24 h postadmission with a significant fall in Glasgow Coma Scale Score. Polymerase chain reaction testing of cerebrospinal fluid suggested enteroviral encephalitis. He responded symptomatically to intravenous immunoglobulins. His immunoglobulin levels were monitored weekly and supplemented to maintain immunoglobulin G level at 10 g/l, but in spite of this, his neurological condition deteriorated and he died after 14 weeks. Rituximab can cause prolonged B-cell deficiency. We speculate that profound immunosuppression induced by rituximab, together with previous chemotherapy, predisposed this patient to fatal enteroviral meningoencephalitis.
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PMID:Enteroviral meningoencephalitis in a patient with non-Hodgkin's lymphoma treated previously with rituximab. 1643 Apr 65

Listeria monocytogenes infection, although rare in horses, can lead to septicaemia, gastroenteritis and abortion or stillborn foals. Equine cerebral listeriosis has been reported, but only in newborn animals. This report describes a Freiberger gelding with severe neuronal symptoms of sudden onset. The animal collapsed within 24 h and was humanely killed. Necropsy revealed multiple small brown to reddish foci within the brain stem and pons. Histopathology demonstrated multifocal suppurative meningoencephalitis with microabscesses and occasional intra-lesional, coccoid to rod-shaped, bacteria. These were identified immunohistochemically as Listeria spp. and further specified as L. monocytogenes by a commercial test system based on in-situ hybridization.
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PMID:Cerebral listeriosis in an adult Freiberger gelding. 1654 74

A lethal case of Brazilian spotted fever (BSF) is presented. Clinical features were initially of gastrointestinal involvement and evolved with progression to septic shock, meningoencephalitis and death on the 6th day of illness. Indirect immunofluorescence assay (IFA) for spotted fever group rickettsia (SFGR) was non-reactive. Diagnosis was confirmed by the polymerase chain reaction (PCR) and the nucleotide sequencing of a fragment of the ompA gene showed 100% homology to Rickettsia rickettsii. BSF has not been reported in the city of Rio de Janeiro in the last three decades, and the present description should alert the clinicians to its presence in urban Rio de Janeiro, and to the differential diagnosis with dengue fever, gastroenteritis, leptospirosis and bacterial septic shock, among others.
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PMID:Characterization of rickettsia rickettsii in a case of fatal Brazilian spotted fever in the city of Rio de Janeiro, Brazil. 1864 53

Adenoviruses are associated with numerous disease outbreaks, particularly those involving d-cares, schools, children's camps, hospitals and other health care centers, and military settings. In addition, adenoviruses have been responsible for many recreational water outbreaks, including a great number of swimming pool outbreaks than any other waterborne virus (Gerba and Enriquez 1997). Two drinking water outbreaks have been documented for adenovirus (Divizia et al. 2004; Kukkula et al. 1997) but none for food. Of the 51 known adenovirus serotypes, one third are associated with human disease, while other infections are asymptomatic. Human disease associated with adenovirus infections include gastroenteritis, respiratory infections, eye infections, acute hemorrhagic cystitis, and meningoencephalitis (Table 2). Children and the immunocompromised are more severely impacted by adenovirus infections. Subsequently, adenovirus is included in the EPA's Drinking Water Contaminant Candidate List (CCL), which is a list of unregulated contaminants found in public water systems that may pose a risk to public health (National Research Council 1999). Adenoviruses have been detected in various waters worldwide including wastewater, river water, oceans, and swimming pools (Hurst et al. 1988; Irving and Smith 1981; Pina et al. 1998). Adenoviruses typically outnumber the enteroviruses, when both are detected in surface waters. Chapron et al. (2000) found that 38% of 29 surface water samples were positive for infectious Ad40 and Ad41. Data are lacking regarding the occurrence of adenovirus in water in the US, particularly for groundwater and drinking water. Studies have shown, however, that adenoviruses survive longer in water than enteroviruses and hepatitis A virus (Enriquez et al. 1995), which may be due to their double-stranded DNA. Risk assessments have been conducted on waterborne adenovirus (Crabtree et al. 1997; van Heerden et al. 2005c). Using dose-response data for inhalation from Couch et al. (1966), human health risks of infection, illness and death have been determined for various adenovirus exposures. Crabtree et al. (1997) conclude that, even at an adenovirus concentration of 1 per 1,000 L of drinking water, annual risks of infection exceed the suggested risk recommendation of 1 x 10(-4) per yr (Regli et al. 1991) (Table 8). Using the same exposure and dose-response assumptions, van Heerden et al. (2005c) determined annual risks of infection to be 1-1.7 x 10(-1) for two drinking water samples from South Africa containing 1.40 and 2.45 adenoviruses per 10,000 L, respectively. This present study estimated annual risks of infection associated with varying levels of adenoviruses per 100 L (Table 9). By assuming a 2 L/d exposure and utilizing the exponential model at r = 0.4172 (Haas et al. 1993), yearly risks exceed the risk recommendation of 1 x 10(-4) at every exposure level. There are limited data regarding the removal of adenoviruses by conventional water treatment or other physical-chemical treatment processes, but studies do suggest that adenoviruses are of equal or greater sensitivity to oxidizing disinfectants, when compared to waterborne viruses (the most resistant to ultraviolet light). Data suggest that the chlorine doses applied to control other waterborne viruses are more effective against adenovirus, resulting in a greater than 4-log10 removal of adenoviruses by conventional treatment and chlorination. If treatment can achieve a 4-log10 removal of adenoviruses, then, based on the risk levels presented in Table 9, surface water concentrations should not exceed 0.5 adenoviruses per 100 L (Fig. 2). More data are needed regarding effectiveness of water treatment against adenovirus and the human-virus dose-response relationship to fully understand the role of adenovirus as a waterborne public health threat.
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PMID:Waterborne adenovirus. 1925 37

A 31/2-year-old child presented with symptoms of acute gastroenteritis and evidence of central nervous system disease. Evaluation revealed findings consistent with meningoencephalitis and rotavirus detected in the cerebrospinal fluid by polymerase chain reaction. A review of the literature describes 23 cases of central nervous system disease attributed to rotavirus.
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PMID:Rotavirus meningoencephalitis in a previously healthy child and a review of the literature. 2011 93

Listeria monocytogenes causes listeriosis, a human foodborne infection leading to gastroenteritis, meningoencephalitis and maternofetal infections. InlA and InlB, two L. monocytogenes surface proteins, interact with their respective receptors E-cadherin and Met and mediate bacterial entry into human cultured cells. Here, we present protocols for studying listeriosis in three complementary animal models: (i) the human E-cadherin (hEcad) transgenic mouse line; (ii) the knock-in E16P mouse line; and (iii) the gerbil, in which both InlA-E-cadherin and InlB-Met species-specific interactions occur as in humans. Two routes of infection are described: oral inoculation, the natural route for infection; and intravenous inoculation that bypasses the intestinal barrier. We describe how to monitor L. monocytogenes infection, both qualitatively by imaging techniques and quantitatively by bacterial enumeration. The advantage of these methods over the classical intravenous inoculation of L. monocytogenes in wild-type mice (in which the InlA-E-cadherin interaction does not occur) is that it allows the pathophysiology of listeriosis to be studied in animal models relevant to humans, as they are permissive to the interactions that are thought to mediate L. monocytogenes crossing of human host barriers. The whole procedure (inoculation, in vivo imaging, bacterial enumeration, histopathology) takes one full week to complete, including 3 d of actual experiments.
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PMID:Modeling human listeriosis in natural and genetically engineered animals. 1944 38

Listeria monocytogenes is a Gram-positive bacterium responsible for a severe infection associated with different clinical features (gastroenteritis, meningoencephalitis, and abortion in pregnant women). These pathologies are caused by the unusual capacity of the bacterium to cross three host barriers during infection and to invade nonphagocytic cells. To invade host cells, Listeria uses two proteins, InlA and InlB, which have specific receptors on the host-cell surface, E-cadherin and Met, respectively. Here, we discuss the specificity of the InlA-E-cadherin interaction, the signaling cascade activated on E-cadherin engagement by InlA, and the role of InlA and E-cadherin in the breaching of host barriers and the dissemination of the infection.
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PMID:Listeria monocytogenes internalin and E-cadherin: from bench to bedside. 2006 1

Coxsackievirus B4 (CVB4) can cause a broad range of diseases such as aseptic meningitis, meningoencephalitis, myocarditis, hepatitis, pancreatitis, gastroenteritis, necrotizing enterocolitis, pneumonia and sudden death in the neonates. CVB4 has also been implicated as a possible etiological agent for type 1 insulin dependent diabetes mellitus (IDDM). In this study, the possibility of RNA interference (RNAi) as a potential therapeutic approach to treat CVB4 infection was explored. The results showed that the Rhabdomyosarcoma (RD) cells treated with 19-mer siRNAs displayed high specificity against CVB4 replication without displaying any sign of target effects. The siRNA targeting the 3C(pro) region of CVB4 genome was also established to be the most effective in inhibition of CVB4 replication in RD cell line in a dosage dependent manner, indicating its potential to be developed as an antiviral strategy against CVB4.
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PMID:Development of potential antiviral strategy against coxsackievirus B4. 2021 33

A 1-week old, two-humped female camel (Camelus bactrianus) calf with continual whining, epiphora, anorexia, muscle twitching, and lateral recumbency was referred to a veterinary hospital. Although she died shortly after preliminary clinical examination, but necropsy was performed and tissue samples were taken for further microbiological and pathological examinations. On bacteriological investigation, Salmonella typhimurium and Streptococcus agalactiae were isolated. Histopathologically, lesions consisted of hyperemia and hemorrhage in all serosal and mucosal surfaces, gastroenteritis, and purulent ascites, associated with suppurative omphalitis. Acute nutmeg liver demonstrated centrilobular congestion and moderate fatty changes without any inflammatory cell infiltration. The abomasal and intestinal mucosa were hemorrhagic and erosive. The brain was hyperemic with severe fibrinopurulent meningoencephalitis. Except for dromedary camels and llamas, there has been no previous report of an acute, fatal septicemia in a two-humped camel calf due to S. typhimurium accompanied by S. agalactiae.
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PMID:Septicemic salmonellosis in a two-humped camel calf (Camelus bactrianus). 2056 2


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