Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0016719 (Friedreich's ataxia)
 2,098 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
mature T-cell proliferation 1 13.9
STM7 13.6
Frataxin 13.6
frataxin 13.6
FRDA 13.3
GAA1 12.6
ISD11 12.4
NFS1 11.9
GAA 11.9
H2AFY2 11.9
IOSCA 11.9
MTIF2 11.9
ATLD 11.6
PMPCA 11.6
ISCU 11.4
DCYTB 11.3
SCA7 11.0
PIP5K1B 11.0
lipoic acid-containing protein 10.9
FARS 10.8
mitochondrial ferritin 10.8
GRX5 10.7
SACS 10.7
SANDO 10.6
pitrilysin metallopeptidase 1 10.6
SCA2 10.5
RNF126 10.5
SCA12 10.5
MRS3/4 10.5
FAD1 10.4
CMTX5 10.4
GLRX5 10.4
POLG protein 10.3
SCA10 10.3
CT51 10.3
putative DNA binding protein 10.3
Caytaxin 10.3
TGM6 10.3
PRKACG 10.3
cysteine desulfurase 10.3
ALS4 10.3
DRPLA 10.3
senataxin 10.2
IscU 10.2
GRAP 10.2
aprataxin 10.1
SCA1 10.1
SPTBN2 10.0
APTX 10.0
ABCB7 10.0
SPG7 9.9
ANO10 9.8
KGDHC 9.8
COG5 9.8
SCA8 9.8
SCA5 9.7
NCLX 9.6
mitoferrin 9.6
TSA-1 9.6
C10orf2 9.6
SPG3 9.6
SCA3 9.5
dentatorubral-pallidoluysian atrophy 9.5
SETX 9.5
JPH3 9.4
ZO2 9.4
ZFYVE26 9.4
aconitase 9.3
SCA6 9.3
SEPW1 9.2
CHCHD4 9.2
Jac1 9.2
DARS2 9.2
CRIPT 9.2
alpha-tocopherol transfer protein 9.2
HEMO 9.1
pantothenate kinase 9.1
iron regulatory protein 2 9.1
MSS4 9.0
MERRF 9.0
ADCK3 9.0
meiotic recombination 11 8.9
AGK 8.9
IkappaB kinase complex-associated protein 8.9
TMEM165 8.9
ATXN10 8.9
Lipoyl synthase 8.8
mitochondrial intermediate peptidase 8.8
neurofilament-light 8.8
ferritin-like protein 8.8
Hallervorden-Spatz syndrome 8.8
TMEM70 8.8
FAST-1 8.7
SCA17 8.7
P94 8.7
PDPK1 8.6
SARA 8.6
lipoamide 8.6
AAT1 8.6
NDUFA1 8.6
HSAN1 8.5
HMSN I 8.5
NARP 8.4
CCTG 8.4
TTBK2 8.4
fatty acid 2-hydroxylase 8.4
electron transfer flavoprotein-ubiquinone oxidoreductase 8.4
NifU 8.3
puratrophin-1 8.3
BCS1L 8.3
Glutaredoxin-1 8.3
SDH2 8.3
3-hydroxy-3-methylglutaryl-CoA lyase 8.3
KCNC3 8.2
SIL1 8.2
hephaestin 8.2
PANK2 8.2
ELP3 8.2
dihydrolipoamide succinyltransferase 8.2
HADHA 8.1
class I histone deacetylase 8.1
mitochondrial aconitase 8.1
CMT2A 8.1
EA1 8.0
EA2 8.0
ALAS1 8.0
FRAXE 8.0
ferroportin 1 8.0
CTP:phosphoethanolamine cytidylyltransferase 8.0
MTP1 8.0
iron regulatory protein 1 8.0
transferrin receptor 2 8.0
lipoamide dehydrogenase 8.0
ethanolamine kinase 7.9
muscle creatine kinase 7.9
adenosine monophosphate deaminase 7.9
Aconitase 7.9
OPA3 7.8
REEP1 7.8
FGF14 7.8
spinocerebellar ataxia type 2 7.8
TR-beta 7.7
nibrin 7.6
ferroportin1 7.6
ALAS 7.6
MELAS 7.6
coproporphyrinogen oxidase 7.6
InsP3R1 7.6
NFAT3 7.6
LHON 7.6
IRP1 7.5
ITPR1 7.5
Barth syndrome 7.4
FTH1 7.4
ferrochelatase 7.4
POLG 7.4
periaxin 7.4
MSH3 7.4
Kufor-Rakeb syndrome 7.4
NCF2 7.4
more...
Disease
FRDA2 13.9
Gaze palsy 13.9
Friedreich's ataxia 13.9
Temporal pallor 13.9
FRDA 13.5
Early Onset Cerebellar Ataxia 13.3
Early onset cerebellar ataxia with retained tendon reflexes 13.2
CMT2A2 12.9
Sanger-Brown 12.9
Marie's ataxia 12.3
hereditary ataxia 12.2
IOSCA 12.1
ATLD 11.9
SCAE 11.9
Roussy-Levy 11.9
FRA12A 11.6
SCA25 11.6
Spastic ataxia 11.6
Ocular siderosis 11.3
HMSN VI 11.2
FARR 11.1
AOA2 11.0
SCA7 11.0
SCA23 10.9
SCA16 10.9
alcoholic cerebellar degeneration 10.7
Spinocerebellar degeneration 10.7
CMTX5 10.6
SANDO 10.6
SCA12 10.5
SCA6 10.5
SCA2 10.5
Duchenne's disease 10.4
SCA5 10.3
X-linked sideroblastic anemia 10.3
VED 10.2
olivopontocerebellar atrophy 10.1
SCA1 10.1
SCA15 10.0
Neuromuscular scoliosis 10.0
SPG7 9.9
vitamin E deficiency 9.8
MILS 9.8
SCA28 9.6
SCA8 9.6
SCA4 9.5
Fazio-Londe 9.4
Herpes zoster oticus 9.3
Andermann syndrome 9.3
HMSN I 9.3
disorders of iron metabolism 9.3
SCA14 9.2
SACS 9.2
Machado-Joseph disease 9.1
allergic rash 9.1
SPG31 9.0
Episodic ataxia 9.0
MERRF 9.0
FRAXE 8.9
hereditary chorea 8.9
Cerebellum 8.9
SCAN1 8.8
Cerebellar atrophy 8.8
ALS4 8.7
MGA3 8.7
OPA3 8.6
Kennedy syndrome 8.6
Thiamine-responsive megaloblastic anemia 8.6
HMSN I 8.6
SCA17 8.6
spastic paraplegia 8.6
sideroblastic anemia 8.6
Auditory neuropathy 8.6
Speech impairment 8.5
hyponasality 8.5
FXTAS 8.4
Kugelberg-Welander 8.4
cerebellar syndrome 8.3
Channelopathies 8.2
Pontocerebellar hypoplasia 8.1
acquired dyslexia 8.1
Refsum disease 8.1
HSAN1 8.1
FRAXA 8.1
Keshan disease 8.1
Chronic progressive external ophthalmoplegia 8.0
Leber's hereditary optic neuropathy 8.0
MELAS 8.0
thrombopathy 8.0
TGCT 8.0
psycho-organic syndrome 8.0
Hallervorden-Spatz disease 8.0
Complex I deficiency 8.0
Barth syndrome 7.9
mitochondrial disease 7.8
white muscle disease 7.8
Charcot-Marie-Tooth disease 7.8
DM1 7.8
spinal degeneration 7.8
sensory neuropathy 7.7
HDL1 7.7
multifocal atrial tachycardia 7.7
Hypertrophic cardiomyopathy 7.7
MELAS 7.7
tocopherol deficiency 7.7
Oropharyngeal dysphagia 7.7
disorders of amino acid metabolism 7.6
hypertrophic cardiomyopathy 7.6
degenerative disease 7.5
hereditary motor and sensory neuropathy 7.5
Spinocerebellar ataxia 7.5
Leigh syndrome 7.4
optic atrophy 7.4
apraxia 7.4
Kearns-Sayre syndrome 7.4
fragile X syndrome 7.3
Huntington's disease 7.2
PARK6 7.2
McLeod syndrome 7.2
Kufs' disease 7.2
cardiomyopathy 7.2
Upper limb 7.2
SPG11 7.1
eye movement disorder 7.1
FANCD1 7.1
AAT1 7.1
neuromuscular disorder 7.1
hereditary sensory neuropathy 7.1
Emery-Dreifuss muscular dystrophy 7.0
disorders of carbohydrate metabolism 7.0
iron overload 7.0
CLN6 7.0
myoclonus epilepsy 7.0
Danon disease 7.0
IgG subclass deficiency 6.9
Parinaud's syndrome 6.9
Wolfram syndrome 6.9
SBMA 6.9
OPA1 6.8
gluten sensitivity 6.8
AOA 6.8
progressive muscular atrophy 6.8
Multiple system atrophy 6.8
early disease onset 6.8
lipoproteinemia 6.8
DM2 6.7
tabes 6.7
Mohr 6.7
xanthomatosis 6.7
familial dysautonomia 6.7
FRA 6.6
Optic neuropathy 6.6
orphan disease 6.6
RAT 6.6
mitochondrial myopathy 6.6
CMTX 6.6
scoliosis 6.6
GAN 6.6
tropical sprue 6.5
Joubert syndrome 6.5
more...
Symptom
poor balance and coordination 12.3
urgent urination 12.3
Ataxic 9.3
Pyramidal signs 9.3
cerebellar ataxia 9.1
ataxia 9.0
dysarthria 8.2
ataxic gait 8.1
inanition 7.1
neurological disability 6.6
exertional chest pain 6.6
abnormal gait 6.6
intention tremor 6.4
impaired motor coordination 6.3
chorea 6.2
paraparesis 5.9
athetosis 5.9
male subfertility 5.8
ophthalmoplegia 5.8
spasticity 5.7
DNA marker 5.6
incoordination 5.4
dystonia 5.4
loss of balance 5.1
clumsiness 4.8
Gastrointestinal symptoms 4.7
myoclonus 4.6
pallor 4.6
tremor 4.5
CSR 4.5
clonus 4.4
hypotonia 4.2
weakness 4.1
bradykinesia 3.7
thinning 3.6
hypertonia 3.6
hyperoxia 3.5
asthenia 2.5
memory loss 2.1
apathy 1.9
syncope 1.7
dizziness 1.6
paresthesia 1.6
ENT 1.5
lethargy 1.4
paresis 1.4
back pain 1.3
starvation 1.3
anorexia 1.1
angina 1.1
spasm 1.0
nausea 1.0
hypercapnia 0.9
seizures 0.9
chest pain 0.8
dyspnea 0.7
analgesia 0.7
collapse 0.7
splenomegaly 0.6
anesthesia 0.6
discomfort 0.4
discomfort 0.3
sleepiness 0.2
functional recovery 0.2
exhaustion 0.2
headache 0.1
abdominal pain -0.0
fatigue -0.2
respiratory distress -0.4
cough -0.7
overweight -0.8
vomiting -1.1
pain -1.3
diarrhea -1.9
Drug
Idebenone 11.0
Parnate 9.6
TTC 8.7
Chantix 8.4
Elm 7.9
Tetrofosmin 7.7
CTT 7.5
Epoetin alfa 7.2
Epoetin alfa 6.6
GVG 6.5
Desferal 5.9
Vitamin E 5.9
DM1 5.8
Desferal 5.8
Exenatide 5.6
Guanidine 5.5
Guanidine 5.5
Flunitrazepam 5.4
vitamin E 5.1
ADM 4.9
EPI 4.8
Vitamin B12 4.6
Heme 4.3
AGG 4.3
TAT 4.2
Alliance 4.1
Gastro 4.1
Clopidogrel 3.8
Estrogens 3.8
CoCl2 3.6
CoCl2 3.6
Methylene blue 3.6
ZnCl2 3.5
ZnCl2 3.5
Posture 3.5
FeCl3 3.5
BH4 3.3
MgSO4 3.3
Ranitidine 3.3
ROS 3.2
TAC 3.2
Simvastatin 3.2
Glutathione 3.1
Parkin 3.0
Parkin 3.0
NADH 2.9
Dakar 2.8
TMS 2.7
pyridoxal phosphate 2.6
citric acid 2.2
niacin 2.0
CSF 2.0
Adriamycin 1.7
ICI 1.5
Mutagen 1.4
lysine 1.0
ROC 1.0
THF 0.9
DNase I 0.9
ENT 0.8
ABC 0.8
Gel 0.0
MAP -0.0
ascorbate -0.6
Cardiovasc -1.4
Enzyme
valine dehydrogenase 11.0
IscS 9.8
aconitase 9.2
pantothenate kinase 9.1
phosphoethanolamine cytidylyltransferase 8.9
NADH kinase 8.6
electron transfer flavoprotein dehydrogenase 8.1
ethanolamine kinase 7.9
dihydrolipoamide succinyltransferase 7.7
3-hydroxy-3-methylglutaryl-CoA lyase 7.6
ferrochelatase 7.4
coproporphyrinogen oxidase 6.9
biliverdin reductase 6.8
LipA 6.7
diaphorase 6.5
Lod 6.3
PIP kinase 6.2
SCP 6.1
PDH 6.1
MPP 6.0
pyruvate dehydrogenase 5.7
succinate dehydrogenase 5.7
pyruvate dehydrogenase 5.4
pyruvate dehydrogenase 5.4
alpha-L-iduronidase 5.3
fumarase 5.3
biotinidase 5.3
pyruvate decarboxylase 5.2
alpha-ketoglutarate dehydrogenase 5.2
complex I 5.0
TRS 4.9
citrate synthase 4.8
isopeptidase 4.7
lecithin:cholesterol acyltransferase 4.7
porphobilinogen deaminase 4.6
polynucleotide kinase 4.5
acyl-CoA dehydrogenase 4.4
ceruloplasmin 4.4
TOR 4.4
rhodanese 4.4
glutamate synthase 4.3
ClpP 4.3
glutamate synthase 4.3
acyl-CoA dehydrogenase 4.3
TAT 4.3
cytochrome oxidase 4.2
glutamate synthase 4.2
thioredoxin reductase 4.2
LasR 4.1
delta-aminolevulinic acid dehydratase 4.0
ALA synthase 3.9
heme oxygenase 3.9
NADH dehydrogenase 3.8
PDK1 3.8
GRK5 3.8
hexosaminidase 3.7
histone acetyltransferase 3.5
RNase H 3.5
pyruvate carboxylase 3.3
botulinum neurotoxin 3.0
adenylate kinase 3.0
chaperonin 2.8
phosphoglycerate kinase 2.8
glutathione peroxidase 2.8
malate dehydrogenase 2.7
MIP 2.6
pyruvate kinase 2.5
peroxiredoxin 2.5
DNA ligase 2.5
DNA ligase 2.5
DNA polymerase 2.4
diaphorase 2.4
isocitrate dehydrogenase 2.3
thyroid peroxidase 2.3
isocitrate dehydrogenase 2.1
RNA polymerase 2.1
lipoprotein lipase 2.1
thymidylate synthase 2.1
phosphofructokinase 2.0
proteasome 1.9
phosphoenolpyruvate carboxykinase 1.9
superoxide dismutase 1.9
phosphoenolpyruvate carboxykinase 1.8
glutamate dehydrogenase 1.8
glutamate dehydrogenase 1.8
CAD 1.8
CAD 1.8
glutamate dehydrogenase 1.8
CAD 1.7
phosphoenolpyruvate carboxykinase 1.7
endonuclease 1.7
creatine kinase 1.7
deaminase 1.6
dihydrofolate reductase 1.4
ACE 1.3
AMP-activated protein kinase 1.2
GSK 1.2
ATP synthase 1.1
MAP 1.0
caspase-9 1.0
glucose-6-phosphate dehydrogenase 1.0
catalase 0.9
RNase 0.9
caspase-3 0.8
RNase 0.8
topoisomerase 0.7
transcriptase 0.7
glutathione reductase 0.7
topoisomerase 0.6
monoamine oxidase 0.5
aspartate aminotransferase 0.5
ATPase 0.5
chymotrypsin 0.5
protein kinase 0.4
AMPK 0.3
luciferase 0.3
acid phosphatase 0.2
PARP 0.2
neuraminidase 0.1
beta-galactosidase 0.1
tyrosine hydroxylase 0.0
ACS -0.0
APC -0.1
lipase -0.3
phosphodiesterase -0.3
peroxidase -0.5
alanine aminotransferase -0.8
lactate dehydrogenase -0.9
mitogen-activated protein kinase -1.1
thrombin -1.1
renin -1.2
focal adhesion kinase -1.5
protein kinase C -1.7
ERK -2.7
Compound
Dyclonine 12.3
Dyclonine 11.6
C7H6N2O3 11.6
DFH 9.4
TTC 8.4
2-aminobenzamide 8.2
Calpeptin 8.0
Choline chloride 7.8
Diacetoxyscirpenol 7.3
coenzyme Q10 7.3
Lipozyme 7.1
Coenzyme Q10 6.8
Dimethyl fumarate 6.8
Tranylcypromine 6.7
Atracurium 6.4
Emery 6.3
CoQ 6.2
NFA 5.9
4-phenyl-1,2,3,6-tetrahydropyridine 5.9
Desferal 5.9
INN 5.9
Sulforaphane 5.9
Amantadine 5.9
iron 5.7
AAB 5.7
AAB 5.7
Purine 5.6
Vitamin E 5.6
DFO 5.5
PDH 5.5
HPT 5.5
Vigabatrin 5.4
BSO 5.3
TBE 5.3
Alizarin Red S 5.2
MAOA 5.1
TCC 5.1
SDA 4.9
Flumazenil 4.9
PAPS 4.9
Antimycin 4.9
CAA 4.9
Protoporphyrin IX 4.9
VMA 4.9
Creatine 4.8
IPN 4.7
Topiramate 4.7
Isoform 4.7
Thiamine 4.6
Bisulfite 4.6
Pyruvate 4.6
5-hydroxytryptophan 4.6
ubiquinone 4.5
beta-alanine 4.5
TTP 4.5
TTA 4.4
Heme 4.4
Tiron 4.4
DDVP 4.4
ATC 4.4
L-carnitine 4.3
ATC 4.3
benzamide 4.3
Taurine 4.3
5-HTP 4.2
isobutyric acid 4.2
5-HTP 4.2
malonic acid 4.2
HVA 4.1
MPP 4.1
Tumor Necrosis Factor 4.1
MPP 4.1
tetraphosphate 4.0
Pima 4.0
Methylene blue 4.0
Thioredoxin 4.0
MCP 4.0
DTT 3.9
Isoflurane 3.9
DTT 3.8
salicylaldehyde 3.8
salicylaldehyde 3.8
salicylaldehyde 3.8
salicylaldehyde 3.8
salicylaldehyde 3.8
salicylaldehyde 3.8
GSSG 3.7
phosphocreatine 3.6
TBP 3.5
delta-aminolevulinic acid 3.4
Neuronal 3.4
HMG-CoA 3.4
5-HIAA 3.4
DPA 3.3
DPA 3.3
DPA 3.3
DPA 3.3
DPA 3.3
TBP 3.3
Inositol 3.2
8-OHdG 3.2
Histone 3.2
Phosphatidylcholine 3.2
aspartic acid 3.2
TAA 3.2
Biotin 3.2
GM2 3.2
2-nonenal 3.1
ubiquinol 3.1
Lac 3.1
aspartic acid 3.1
aspartic acid 3.1
C2H2 3.1
Choline 3.0
SPM 3.0
NADH 2.9
TXA2 2.8
TRH 2.8
aspartic acid 2.8
pyrimidine 2.8
pyrimidine 2.7
25-dihydroxycholecalciferol 2.7
TPP 2.7
nicotinamide 2.7
Hemoglobin 2.7
NAD 2.7
GPT 2.7
2-oxoglutarate 2.6
NAD 2.6
NTA 2.6
MPTP 2.5
TBI 2.5
DIC 2.5
CIT 2.5
ATP 2.4
NADP 2.4
Paclitaxel 2.4
Rhodamine B 2.4
cysteine 2.4
AAA 2.4
Retinal 2.3
nicotinic acid 2.3
nicotinic acid 2.3
H2O2 2.3
superoxide radical 2.3
COX 2.3
DNA 2.3
nicotinic acid 2.3
GSH 2.2
GSH 2.2
Glutamate 2.2
Substance P 2.2
N-acetylaspartate 2.2
Curcumin 2.2
Rapamycin 2.2
Valproic acid 2.2
isoleucine 2.2
succinic acid 2.1
isoleucine 2.1
glucose-6-phosphate 2.1
more...