Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0016719 (Friedreich's ataxia)
 2,098 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
frataxin 1111
GAA 386
Mol 185
Frataxin 167
Sep 112
FRDA 88
aconitase 69
axonal 66
ATP 47
ferritin 41
MRI 33
insulin 30
SCA2 28
SCA1 27
histone 24
cysteine desulfurase 23
SCA3 21
histone deacetylase 21
SCA6 20
A-T 17
SCA7 17
IscU 17
transferrin 16
NFS1 16
ISCU 16
SACS 16
lipoamide dehydrogenase 16
Nrf2 16
erythropoietin 15
NMR 14
superoxide dismutase 14
ISD11 13
GBS 13
mitochondrial ferritin 12
amyloid precursor protein 12
transferrin receptor 12
ROS 12
unknown function 12
dentatorubral-pallidoluysian atrophy 11
NADH 11
hemoglobin 11
erythroid 11
ferredoxin 11
ferrochelatase 10
glutathione peroxidase 10
fused 10
pyruvate dehydrogenase 10
alpha-tocopherol transfer protein 10
pyruvate dehydrogenase complex 10
GSH 10
muscle creatine kinase 9
GAA1 9
aprataxin 9
GABA 9
pantothenate kinase 9
CSF 8
hemochromatosis 8
MELAS 8
DRPLA 8
telomeric 8
NAD 8
p53 8
ubiquinone 8
citrate synthase 8
cardiac muscle 8
Hsp60 8
endoplasmic reticulum 8
caspase-3 7
X-linked 7
SPG7 7
prion 7
DM1 7
MERRF 7
glutamic acid decarboxylase 6
DM2 6
brain-derived neurotrophic factor 6
ataxin-3 6
lipoamide 6
She 6
hereditary hemochromatosis 6
UTR 6
ubiquitin 6
ABCB7 6
catalase 6
senataxin 6
FMRP 5
heme oxygenase-1 5
STM7 5
Histone deacetylase 5
DNA polymerase 5
ceruloplasmin 5
growth hormone 5
glial fibrillary acidic protein 5
OPA1 5
HFE 5
polypeptide 5
SARA 5
proteasome 5
alpha-fetoprotein 5
Mal 5
ALS4 5
HDAC3 5
cytochrome c 5
AR protein 5
ACS 5
ATM 5
prolactin 5
mitochondrial aconitase 5
GLRX5 4
PGC 4
neuron-specific enolase 4
Emery-Dreifuss muscular dystrophy 4
peroxisome proliferator-activated receptor gamma 4
anonymous 4
MSA 4
SCA10 4
phosphatase 4
Rett syndrome 4
FARS 4
transferrin receptor 2 4
Ferritin 4
creatine kinase 4
FMR1 4
CCTG 4
POLG 4
NAD+ 4
peroxisome proliferator-activated receptor 4
divalent metal transporter 1 4
TTP 4
reductase 4
MSH2 4
P100 4
SCA12 4
iron regulatory protein 2 4
MRS 4
histone H3 4
HEMO 4
spinocerebellar ataxia type 2 4
SCA8 4
albumin 4
S protein 4
ATPase 4
NCLX 4
mitoferrin 4
endonuclease 4
MOT 4
EPI 4
Pol 4
FRAXE 4
Hallervorden-Spatz syndrome 4
C9orf72 4
Barth syndrome 4
huntingtin 4
HDAC 3
metalloprotease 3
strabismus 3
MSH3 3
ferroportin 1 3
SOD2 3
thioredoxin reductase 3
more...
Disease
Friedreich's ataxia 2098
cardiomyopathy 198
Huntington's disease 134
Alzheimer's disease 109
diabetes 107
Parkinson's disease 104
hypertrophic cardiomyopathy 92
neuropathy 77
amyotrophic lateral sclerosis 66
DM1 63
FRDA 61
vitamin E deficiency 55
Cerebellum 55
iron overload 53
scoliosis 53
hereditary ataxia 52
ATM 50
Charcot-Marie-Tooth disease 44
fragile X syndrome 38
spastic paraplegia 37
heart failure 36
olivopontocerebellar atrophy 35
multiple sclerosis 34
degenerative disease 34
Machado-Joseph disease 33
apraxia 31
peripheral neuropathy 30
ventricular hypertrophy 29
mitochondrial disease 28
heart disease 28
stroke 28
SCA2 28
SCA1 27
cancer 26
epilepsy 26
dilated cardiomyopathy 26
muscular atrophy 25
sensory neuropathy 25
optic atrophy 25
neurological disease 21
SCA6 20
dementia 18
glucose intolerance 17
Leigh syndrome 17
myopathy 17
SCA7 17
genetic disorder 16
Leber's hereditary optic neuropathy 16
nystagmus 15
malnutrition 15
mental retardation 14
Hypertrophic cardiomyopathy 13
muscular dystrophy 13
mental retardation 13
retinitis pigmentosa 13
cystic fibrosis 12
deafness 12
cognitive impairment 12
neuromuscular disorder 12
hemochromatosis 12
depression 12
movement disorder 11
congestive heart failure 11
iron deficiency 11
parkinsonism 11
cerebellar syndrome 11
polyneuropathy 11
ABL 10
sideroblastic anemia 10
lactic acidosis 10
thalassemia 10
GSH 10
X-linked sideroblastic anemia 10
schizophrenia 10
Wilson's disease 10
cerebral palsy 9
neuroblastoma 9
Spinocerebellar ataxia 9
tumor 9
NOD 8
encephalopathy 8
Duchenne muscular dystrophy 8
Refsum disease 8
MELAS 8
MELAS 8
Kearns-Sayre syndrome 7
immunodeficiency 7
MERRF 7
restless legs syndrome 7
mitochondrial myopathy 7
type 2 diabetes 7
rare disease 7
hereditary hemochromatosis 7
Down syndrome 6
DM2 6
herpes simplex 6
polio 6
bipolar disorder 6
cold 6
wasting 6
ash 6
hereditary motor and sensory neuropathy 6
hypertension 6
myoclonus epilepsy 6
macular degeneration 6
atherosclerosis 6
flutter 6
dysphagia 6
HFA 6
anemia 6
myocardial ischemia 5
NBS 5
protein deficiency 5
metabolic disorder 5
hyperlipidemia 5
confusion 5
cataract 5
carcinoma 5
hypogonadism 5
thiamine deficiency 5
leukemia 5
malabsorption 5
SPG7 5
OPA1 5
VED 4
hypercholesterolemia 4
obesity 4
Syndrome 4
tardive dyskinesia 4
brain atrophy 4
Hallervorden-Spatz disease 4
disorders of iron metabolism 4
blindness 4
diabetic ketoacidosis 4
coronary artery disease 4
Fabry 4
Rett syndrome 4
retinopathy 4
MRS 4
Marie's ataxia 4
SCA12 4
AOA2 4
motor neuron disease 4
TTP 4
Barth syndrome 4
telangiectasia 4
Roussy-Levy 4
FRAXA 4
TTP 4
SACS 4
developmental delay 4
FRAXE 4
Emery-Dreifuss muscular dystrophy 4
HMSN I 4
EPI 4
autism 4
Kugelberg-Welander 4
MSA 4
Early Onset Cerebellar Ataxia 4
xeroderma pigmentosum 3
more...
Symptom
ataxia 526
cerebellar ataxia 133
dysarthria 75
weakness 44
tremor 27
dystonia 23
spasticity 22
ophthalmoplegia 12
paraparesis 11
anesthesia 11
chorea 10
seizures 10
ataxic gait 10
thinning 9
abnormal gait 7
pain 7
myoclonus 7
hypotonia 7
neurological disability 6
incoordination 5
pallor 4
headache 4
hyperoxia 4
starvation 4
angina 3
nausea 3
DNA marker 3
fatigue 3
Ataxic 3
analgesia 3
collapse 3
dyspnea 3
bradykinesia 2
chest pain 2
inanition 2
poor balance and coordination 2
abdominal pain 2
back pain 2
intention tremor 2
discomfort 2
syncope 2
dizziness 2
anorexia 2
discomfort 2
overweight 1
hypertonia 1
memory loss 1
paresis 1
spasm 1
clumsiness 1
paresthesia 1
functional recovery 1
exertional chest pain 1
CSR 1
asthenia 1
respiratory distress 1
clonus 1
urgent urination 1
apathy 1
splenomegaly 1
athetosis 1
impaired motor coordination 1
loss of balance 1
exhaustion 1
cough 1
male subfertility 1
Pyramidal signs 1
diarrhea 1
lethargy 1
Gastrointestinal symptoms 1
vomiting 1
sleepiness 1
hypercapnia 1
ENT 1
Drug
TTC 50
vitamin E 41
Idebenone 17
Vitamin E 13
ROS 12
NADH 11
CSF 8
lysine 8
DM1 6
ADM 6
Cardiovasc 5
CTT 5
Heme 4
Posture 4
EPI 4
TAT 3
Glutathione 3
Alliance 3
citric acid 3
Epoetin alfa 2
Epoetin alfa 2
Vitamin B12 2
Estrogens 2
Parkin 1
Elm 1
MAP 1
ABC 1
Gastro 1
Dakar 1
CoCl2 1
Desferal 1
Clopidogrel 1
ZnCl2 1
MgSO4 1
CoCl2 1
Gel 1
Guanidine 1
GVG 1
AGG 1
niacin 1
Adriamycin 1
ICI 1
Tetrofosmin 1
TAC 1
Simvastatin 1
ascorbate 1
Chantix 1
ENT 1
Parnate 1
ROC 1
pyridoxal phosphate 1
DNase I 1
Mutagen 1
Parkin 1
TMS 1
Ranitidine 1
Exenatide 1
FeCl3 1
Flunitrazepam 1
THF 1
Guanidine 1
Methylene blue 1
BH4 1
ZnCl2 1
Desferal 1
Enzyme
aconitase 69
succinate dehydrogenase 28
IscS 26
complex I 19
pyruvate dehydrogenase 19
diaphorase 16
superoxide dismutase 14
cytochrome oxidase 11
pyruvate dehydrogenase 10
RNA polymerase 10
glutathione peroxidase 10
pyruvate dehydrogenase 10
ferrochelatase 10
pantothenate kinase 9
citrate synthase 8
MPP 8
protein kinase 7
ceruloplasmin 7
catalase 7
proteasome 7
DNA polymerase 6
ATPase 6
ACS 5
caspase-3 4
creatine kinase 4
endonuclease 4
heme oxygenase 4
fumarase 3
TAT 3
PDH 3
valine dehydrogenase 3
peroxidase 3
hexosaminidase 3
luciferase 3
alpha-ketoglutarate dehydrogenase 3
thioredoxin reductase 3
mitogen-activated protein kinase 3
ACE 3
coproporphyrinogen oxidase 2
AMP-activated protein kinase 2
aspartate aminotransferase 2
RNase H 2
acyl-CoA dehydrogenase 2
TOR 2
lipoprotein lipase 2
lecithin:cholesterol acyltransferase 2
pyruvate decarboxylase 2
biliverdin reductase 2
diaphorase 2
NADH dehydrogenase 2
malate dehydrogenase 2
histone acetyltransferase 2
RNase 2
PDK1 2
MIP 2
SCP 2
RNase 2
pyruvate kinase 2
pyruvate carboxylase 1
isopeptidase 1
TRS 1
ethanolamine kinase 1
DNA ligase 1
thymidylate synthase 1
LipA 1
CAD 1
thrombin 1
chymotrypsin 1
CAD 1
NADH kinase 1
delta-aminolevulinic acid dehydratase 1
isocitrate dehydrogenase 1
neuraminidase 1
phosphoglycerate kinase 1
alpha-L-iduronidase 1
ATP synthase 1
chaperonin 1
beta-galactosidase 1
APC 1
isocitrate dehydrogenase 1
lipase 1
PIP kinase 1
acid phosphatase 1
glutamate synthase 1
alanine aminotransferase 1
glutamate synthase 1
biotinidase 1
ERK 1
phosphodiesterase 1
deaminase 1
glutamate dehydrogenase 1
DNA ligase 1
ALA synthase 1
caspase-9 1
focal adhesion kinase 1
glutamate dehydrogenase 1
adenylate kinase 1
porphobilinogen deaminase 1
topoisomerase 1
ClpP 1
phosphofructokinase 1
AMPK 1
glutamate dehydrogenase 1
Lod 1
topoisomerase 1
monoamine oxidase 1
PARP 1
protein kinase C 1
phosphoethanolamine cytidylyltransferase 1
glutamate synthase 1
phosphoenolpyruvate carboxykinase 1
GRK5 1
peroxiredoxin 1
phosphoenolpyruvate carboxykinase 1
thyroid peroxidase 1
dihydrolipoamide succinyltransferase 1
3-hydroxy-3-methylglutaryl-CoA lyase 1
glutathione reductase 1
MAP 1
glucose-6-phosphate dehydrogenase 1
polynucleotide kinase 1
acyl-CoA dehydrogenase 1
phosphoenolpyruvate carboxykinase 1
lactate dehydrogenase 1
rhodanese 1
dihydrofolate reductase 1
transcriptase 1
tyrosine hydroxylase 1
electron transfer flavoprotein dehydrogenase 1
GSK 1
botulinum neurotoxin 1
CAD 1
renin 1
LasR 1
Compound
iron 476
DNA 264
Dec 124
oxygen 104
Clin 96
TTC 50
ATP 47
glucose 46
calcium 33
Cardiol 30
cysteine 26
coenzyme Q10 24
zinc 21
hydrogen 20
copper 18
GSH 13
GSH 13
His 13
Vitamin E 13
NADH 11
glutamate 11
NAD 11
H2O2 10
Coenzyme Q10 9
ubiquinone 9
GABA 9
pyrimidine 9
pyrimidine 9
GABA 9
phosphate 9
lysine 8
NAD 8
water 8
Neuronal 8
sodium 7
aspartic acid 7
nitrogen 7
Asp 7
glutamine 7
nicotinamide 7
manganese 6
aspartic acid 6
selenium 6
aspartic acid 6
CoQ 6
aspartic acid 6
nitric oxide 6
5-hydroxytryptophan 5
ACS 5
Heme 5
sulfate 5
methionine 5
L-carnitine 5
ACS 5
PEG 5
alanine 5
GSSG 5
galactose 4
benzamide 4
arginine 4
ammonium 4
phosphorus 4
CO2 4
phosphocreatine 4
TTP 4
Ile 4
acetate 4
salt 4
DFO 4
2-aminobenzamide 4
NADP 4
Hemoglobin 3
Taurine 3
isoleucine 3
Sulforaphane 3
cAMP 3
isoleucine 3
Lipozyme 3
Histone 3
N-acetylcysteine 3
2-oxoglutarate 3
Insulin 3
COS 3
PDH 3
TRH 3
ADP 3
TEM 3
Pyruvate 3
mercury 3
urea 3
glycerol 3
beta-alanine 3
valine 3
Purine 3
Bisulfite 2
DMSO 2
retinoic acid 2
MCP 2
potassium 2
serine 2
Retinal 2
aluminum 2
silver 2
DTT 2
BSO 2
MPP 2
Glutamate 2
TCC 2
MPP 2
Curcumin 2
ethanol 2
NADPH 2
Amantadine 2
Methylene blue 2
methane 2
cobalt 2
leucine 2
superoxide radical 2
ADP 2
Thiamine 2
ADP 2
PEG 2
tryptophan 2
HVA 2
quinoline 2
MPTP 2
cyanide 2
HPT 2
Creatine 2
8-OHdG 2
GTP 2
NADPH 2
tryptophan 2
DTT 2
Emery 2
SDS 2
CAA 2
MTT 2
acetic acid 2
quinoline 2
glutamic acid 2
AMP 1
creatinine 1
nickel 1
acetamide 1
CAT 1
proline 1
COX 1
AAA 1
asparagine 1
THF 1
5-HTP 1
Alizarin Red S 1
cGMP 1
Choline 1
gamma-aminobutyric acid 1
TAA 1
Antimycin 1
5-HT 1
VMA 1
more...