Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0016719 (
Friedreich's ataxia
)
2,098
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Treatment of rats with
asparagine
or glutamine caused substantial increases in glutamine concentrations in cerebellum and medulla oblongata. Insulin treatment caused a diminution of glutamate and GABA in these regions of brain. Since it is now well-established that glutamine is a very efficient precursor of the neurotransmitter pool of glutamate in mammalian brain, treatment with
asparagine
or glutamine could be of therapeutic (replacement) value in the treatment of neurological disorders such as
Friedreich's ataxia
, in which cerebral glutamate concentrations have been found to be diminished.
...
PMID:Effect of asparagine, glutamine and insulin on cerebral amino acid neurotransmitters. 611 88
