Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0016632 (Fox)
 1,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A precursor of 5S ribosomal RNA from Bacillus subtilis (p5A rRNA, 179 nucleotides in length) is cleaved by RNase M5, a specific maturation endonuclease which releases the mature 5S rRNA (m5, 116 nucleotides) and precursor fragments derived from the 5' (21 nucleotides) and 3' (42 nucleotides) termini of p5A rRNA. Previous results (Meyhack, B., et al. (1978) Proc. Natl. Acad. Sci. U.S.A. 75, 3045) led to the conclusion that recognition elements in potential RNase M5 substrates mainly reside in the mature moiety of the precursor. Limited digestion of p5A rRNA with RNase T1 permitted the isolation of a number of test substrates which contained both precursor-specific segments and were unaltered in the immediate vicinity of the cleavage sites, but which differed in that more or less extensive regions of the mature moiety of the p5A rRNA were deleted. Tests of the capacity of these partial molecules to serve as substrates for RNase M5 indicate clearly that the enzyme recognizes the overall conformation of potential substrates, neglecting only the double-helical "prokaryotic loop" (Fox, G.E., & Woese, C.R. (1975) Nature (London) 256, 505).
Biochemistry 1978 Dec 26
PMID:Involvement of the mature domain in the in vitro maturation of Bacillus subtilis precursor 5S ribosomal RNA. 10 77

Exposure of 32P-labelled human platelets to ionophore A23187 results in an increased incorporation of 32P into polypeptides with apparent mol.wts. of 47 000 (P47) and 20 000 (P20), whereas exposure to prostaglandin E1 results in increased labelling of polypeptides with apparent mol.wts. of 24 000 (P24) and 22 000 (P22) [Haslam, Lynham & Fox (1979) Biochem. J. 178, 397-406]. Labelled platelets that had been incubated with ionophore A23187 or prostaglandin E1 were sonicated and rapidly separated into three fractions by differential centrifugation. Electron microscopy and measurement of marker enzymes indicated that the 1300-19 000 gav. particulate fraction was enriched in granules, mitochondria and plasma membranes, that the 19 000-90 000 gav. particulate fraction was enriched in both intracellular and plasma membranes and that the 90 000 gav. supernatant contained only soluble proteins. 32P-labelled phosphopolypeptide P47 was present almost exclusively in the 90 000 gav. supernatant, whereas phosphopolypeptide P20 was largely dephosphorylated under fractionation conditions that protected other phosphopolypeptides. 32P-labelled phosphopolypeptide P24 was enriched in both particulate fractions, but particularly in the 19 000-90 000 gav. fraction, and may therefore be present in both the intracellular and plasma membranes. Phosphopolypeptide P22 appeared to be similarly distributed. Both particulate fractions were capable of the ATP-dependent oxalate-stimulated uptake of Ca2+. When the 19 000-90 000 gav. membrane fraction was prepared from platelets that had been incubated with ionophore A23187, active uptake of Ca2+ did not occur, but when this fraction was isolated from platelets that had been exposed to prostaglandin E1, uptake of Ca2+ was significantly greater than observed with the corresponding membranes from control platelets. It is suggested that phosphorylation of polypeptide P24 (or P22) by a cyclic AMP-dependent protein kinase may promote the active transport of Ca2+ out of the platelet cytosol.
Biochem J 1979 Dec 15
PMID:Subcellular distribution of the different platelet proteins phosphorylated on exposure of intact platelets to ionophore A23187 or to prostaglandin E1. Possible role of a membrane phosphopolypeptide in the regulation of calcium-ion transport. 12 Feb

This study examined the precision of the bivariate method in subjects with high-frequency sensorineural hearing loss. The current bivariate data effectively separated normal hearing subjects from those with pure tone averages of greater than 32 dB HL, in a manner consistent with the results of Popelka and Trumpf (1976) and Margolis and Fox (1977b). However, for persons with high-frequency losses the prediction of hearing levels from acoustic reflex thresholds (ARTs) appears to be complicated. Moderate hearing losses involving 500, 1000 and 2000 Hz ("speech frequencies") as well as higher frequencies were identified on the basis of elevated average ARTs for 500, 1000 and 2000 Hz. Normal ears (pure tone averages of less than 30 dB HL) were isolated from others on the basis of position on the bivariate graph. Those with (1) normal hearing in the "speech frequencies" and a high-frequency loss and (2) a mild loss in the "speech frequencies" and a high-frequency loss, could be separated from those with normal hearing by location on the bivariate graph, and from those with moderate (or worse) losses on the basis of average ART for tones. Consideration of these findings is useful in the evaluation of patients at risk for high-frequency loss, such as patients with noise exposure, and is particularly useful in cases of suspected functional impairment within this population. A modification of the bivariate method is suggested which extends its application to patient populations with a large incidence of high frequency sensorineural hearing loss.
J Speech Hear Res 1979 Dec
PMID:Prediction of hearing levels from acoustic reflex thresholds in persons with high-frequency hearing losses. 51 80

Clinical teaching has become increasingly complex and difficult for nursing instructors. Pressures for public accountability in nursing education and patient care, economic stresses, marked changes in the nursing curricula, and the growth of collective bargaining units have all complicated the task of educating student nurses. Traditional issues focusing on teaching strategies, academic and clinical evaluation concerns have been extensively researched. What are the current issues facing nurse educators? Our project aimed to identify some current student nurse issues in selected nursing programmes. Using a convenience sample, data were collected from the chairmen of nursing education in selected agencies. Analysis following the Fox and Diamond framework (1965) revealed recurring issues relating to mature students, stress and the clinical environment, and the mentor needs are a few of the issues discussed in this paper.
Nurse Educ Today 1992 Dec
PMID:Nurse Education Tomorrow Conference 1991. An examination of selected current student nurse issues. 128 38

Previous work on the developmental aspects of neurobehavioural toxicity in rats and mice has shown the reliability of a variety of procedures aimed at assessing changes that may have widespread functional consequences, for example: (i) modified Fox batteries to study the maturation of various reflexes and responses after birth, (ii) activity/habituation and analgesia tests with age-specific profiles of reactivity to selected drug challenges, and (iii) simple learning tasks such as active and passive avoidance [1]. We will now summarize more recent work on other portions of the behavioural repertoire which deserve to be thoroughly assessed in "higher-tier" studies.
Toxicol Lett 1992 Dec
PMID:Developmental aspects of neurobehavioural toxicity. 147 Nov 79

The first step in developing a quality assurance program for radiation oncology nursing is to define the services the nurse should provide to the patient receiving radiation therapy. The focus of radiation oncology nurses should be quality of life issues provided through their roles as teachers, direct care givers, and counselors. With this focus in mind, a three-phase plan was developed at Fox Chase Cancer Center to operationalize a quality assurance program for radiation oncology nursing based on Guidelines for cancer nursing practice by the Oncology Nursing Society (ONS) and the American Nurses' Association (ANA).
Cancer Nurs 1990 Dec
PMID:Model quality assurance program for radiation oncology nursing. 227 5

1. T-, and L-type Ca2+ channels were studied in cell-attached patch recordings from the cell bodies of chick dorsal root ganglion neurones. All experiments were performed with isotonic BaCl2 (110 mM) in the recording pipette and with isotonic potassium aspartate in the bathing solution to zero the cell membrane potential. 2. L-type channels are distinguished by a unitary slope conductance of 25 pS, activation over the range of membrane potentials between 0 and +40 mV, little inactivation over the course of a 136 ms depolarization, and availability for opening even at depolarized holding potentials (h.p. greater than -40 mV). L channels show a predominant mode of gating (mode 1) characterized by brief openings (approximately 1 ms), occasionally interspersed with another pattern of gating characterized by much longer openings (mode 2). 3. The dihydropyridine (DHP) Ca2+ agonist Bay K 8644 promotes mode 2 activity and shifts the voltage dependence of L-type channel activation towards more negative potentials. It leaves the unitary current-voltage relation unchanged. 4. Nifedipine, a DHP Ca2+ antagonist, strongly inhibits L-type channel activity through an increase in the proportion of blank sweeps. 5. T-type Ca2+ channels are distinguished by a much smaller unitary slope conductance (8 pS) and by activation and inactivation over relatively negative ranges of potential. Inactivation is complete by the end of 136 ms pulses to test potentials beyond -20 mV. 6. N-type Ca2+ channels are distinguished by an intermediate unitary slope conductance (13 pS), and by activation over a range of potentials between those of T- and L-type channels. Inactivation of N-type channels takes place over an exceptionally broad range of holding potentials (-80 to -20 mV). 7. Cell-attached patch data on the voltage dependence of activation and inactivation of T- and N-type channels are in excellent agreement with results from whole-cell recordings (Fox, Nowycky & Tsien, 1987) if allowances are made for variations in external surface potential. 8. Patches containing one or two channels of a single type were used for analysis of gating kinetics. The predominant pattern of activity for each of the channel types is an exponential distribution of relatively brief (approximately 1 ms) openings, and a bi-exponential distribution of short and long closings. 9. Patches containing all possible combinations of channel types were observed. However, preliminary evidence suggests that channels are distributed unevenly over the cell body; clustering of N-type channels is particularly prominent.(ABSTRACT TRUNCATED AT 400 WORDS)
J Physiol 1987 Dec
PMID:Single-channel recordings of three types of calcium channels in chick sensory neurones. 245 Oct 17

The recently described Ta1 antigen is expressed by activated T cells in vitro and in vivo, as observed in patients with certain immune-mediated diseases, such as multiple sclerosis. In this paper we report on the tissue distribution of the Ta1 antigen. Serological testing of human tumour cell lines and immunohistochemical analysis of human tissue sections revealed a reactivity of the anti-Ta1 antibody with normal and malignant tissues of the upper gastro-intestinal tract, the biliary tract, exocrine pancreas and kidney. SDS-PAGE analysis of immunoprecipitates from 125I-labelled cells, employing the anti-Ta1 antibody, yielded a 113-115 kD band from three serologically Ta1 positive tumour cell lines, from a serologically Ta1 negative human EBV-transformed B lymphoblastoid cell line, from peripheral blood mononuclear cells (PBMC) and, as previously described, a 105 kD band from PHA activated T cells (Fox et al., 1984). After endoglycosidase F treatment similar bands of 85 kD were precipitated from activated T cells and from tumour cell lines. It is therefore likely that very similar glycoproteins, which differ only modestly in the size of carbohydrate chains, bear the Ta1 epitope on Ta1 positive tissues.
Clin Exp Immunol 1988 Dec
PMID:Tissue distribution of the T cell activation antigen Ta1. Serological, immunohistochemical and biochemical investigations. 246 91

Controversies about reporting communicable diseases in both the past and present are viewed as political conflicts rather than as scientific or technological issues. Debates about reporting have been ideological and have reflected different attitudes about physicians' authority and social values. Fox describes the work of Hermann Biggs, public health chief in New York City during the mid 1890s, in implementing a compulsory reporting system that stressed confidentiality, as well as the growth of tensions between public and private medicine from 1920 to 1960. Although there has been increased acceptance of recordkeeping and regulation in the past 20 years, the epidemic of acquired immunodeficiency syndrome (AIDS) has reignited the controversy over the use of case reports and has fueled fears in the homosexual population concerning discrimination.
Hastings Cent Rep 1986 Dec
PMID:From TB to AIDS: value conflicts in reporting disease. 354 98

Wilson, Bacon, Kaszniak, and Fox (1982) suggest that the learning of low associate pairs on the Wechsler Memory Scale involves episodic memory alone while the learning of high associate pairs involves semantic memory as well. Tulving (1983) also comments that, whereas some information in episodic memory is relatively unorganized and access to its content tends to be deliberate and requiring conscious effort (e.g., low associate pairs), information in semantic memory is organized and access to its content is more automatic (e.g., high associate pairs). As there may be occasions when it would be useful to compare these two types of memory functioning, differential diagnosis between depressive pseudodementia and organic dementia for example, normative data is provided enabling the calculation of the frequency with which differences between the learning of the two kinds of associate occur, based on the performance of 500 subjects with no known neuropsychiatric involvement.
J Clin Exp Neuropsychol 1986 Dec
PMID:Paired associate learning: normative data for differences between high and low associate word pairs. 378 44


1 2 3 4 5 6 7 8 9 10 Next >>