Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0016632 (Fox)
 1,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Carbon Capture and Storage (CCS) is one of the possible mitigation measures to reduce the CO(2) emissions produced from anthropogenic sources and thus help address the issue of global warming. Accidental CO(2) releases may occur at any of the CCS stages, having potentially harmful consequences on the people who work in the CCS facilities, the general public in their vicinity and the environment. CFD is an increasingly used tool to investigate the behavior of released substances and predict the consequences of hazardous scenarios. This information aids the development of mitigation methods to minimize the consequences of an accident. The validation of numerical codes and models is a necessary preliminary step before their application to safety and risk assessment analysis. In this context, numerical simulations of CO(2) release and dispersion field experiments were performed with a CFD code. The experimental data were taken from the Kit Fox CO(2) gas field experiments which were designed to investigate the effect of ground roughness of industrial process plants and of meteorological conditions on the formation and extent of the CO(2) gas cloud. This study presents a comparison between the simulation results and the experimental measurements in order to assess the accuracy of the code with different modeling approaches.
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PMID:Validation of a numerical code for the simulation of a short-term CO2 release in an open environment: effect of wind conditions and obstacles. 2147 37

Carbon nanotubes with extraordinary properties may become a novel drug and gene delivery tool in nanomedicine; however, insufficient information is available regarding their biosafety. Therefore, this work was performed to study the effect of prenatal exposure of single-walled carbon nanotubes (SWCNTs) on reproductive and neurobehavioral endpoints in mice. Thirty pregnant female mice were assigned to three groups (n = 10 for each group). The two treated groups were injected intraperitoneally (i.p.) with 1 or 10 mg/kg body weight (b.w.) of SWCNTs suspended in 1 ml of phosphate buffer saline (PBS) on gestational days 0 and 3. The control group was injected i.p. with an equal volume of PBS. The neurobehavioral ontogeny of pups was evaluated using a modified Fox battery. A decrease in litter size on postnatal day 2 was observed in the group treated with 10 mg/kg b.w. of SWCNTs whereas no significant differences between groups were observed in any other parameters. The behavioral development of pups did not show significant differences during growth except for the surface righting reflex, which showed significant delay compared to control in the group treated with 1 mg/kg b.w. SWCNTs. Moreover, exposed offspring (10 mg/kg b.w. SWCNTs) displayed enhanced anxiety in the elevated plus maze; however, other ethological analysis (Morris water maze and open field test) did not show behavioral changes in the experimental groups. In conclusion, the present results demonstrated small changes in offspring sensory and motor development following exposure to SWCNTs and support the idea that SWCNT risk assessment merits further investigation.
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PMID:Effects of prenatal exposure to single-wall carbon nanotubes on reproductive performance and neurodevelopment in mice. 2550 Jul 57