Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0016632 (
Fox
)
1,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We report an action of the protein kinase WNK3 on the neuronal mRNA splicing factor
Fox
-1.
Fox
-1 splices mRNAs encoding proteins important in synaptic transmission and membrane excitation.
WNK3
, implicated in the control of neuronal excitability through actions on ion transport, binds
Fox
-1 and inhibits its splicing activity in a kinase activity-dependent manner. Phosphorylation of
Fox
-1 by
WNK3
does not change its RNA binding capacity; instead,
WNK3
increases the cytoplasmic localization of
Fox
-1, thereby suppressing
Fox
-1-dependent splicing. These findings demonstrate a role of
WNK3
in RNA processing. Considering the implication of
WNK3
and
Fox
-1 in disorders of neuronal development such as autism,
WNK3
may offer a target for treatment of
Fox
-1-induced disease.
...
PMID:Protein kinase WNK3 regulates the neuronal splicing factor Fox-1. 2302 29
