Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0016632 (Fox)
 1,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Human neuroblastoma (NB) is a highly malignant tumor arising in cells that originate in the embryonal neural crest. Several lines of investigation suggest that both NB and other tumors of developing tissues are blocked in their ability to differentiate and achieve growth arrest. Since in vivo differentiation of NB has been frequently observed and may be of clinical importance (Fox et al., 1959; Evans et al., 1976), we have utilized the in vitro induction of NB differentiation by retinoic acid (RA) to study the molecular events associated with NB differentiation. We have focused our studies on changes that occur in the expression of various proto-oncogenes during NB tumors cell differentiation because proto-oncogenes are likely to be of central importance in mediating processes critical for cellular growth and maturation. In these studies, we have found that the expression of no fewer than five proto-oncogenes including c-Ha-ras, c-ets-1, and c-fos change during the differentiation of NB cells, while the expression of c-erb-B changes in association with the arrest of growth that occurs during NB differentiation. In some cases the altered expression of a proto-oncogene was transcriptionally regulated, while in others post-transcriptional mechanisms were important.
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PMID:The expression of multiple proto-oncogenes is differentially regulated during retinoic acid induced maturation of human neuroblastoma cell lines. 306 Jul 92

Forkhead Box m1b (Foxm1b) is a subtype of the Fox transcription factor family. It is detected in all proliferative cells, but disappears when cells enter into their terminal differentiation phase. Foxm1b is closely related to hepatocellular growth, mainly through inhibiting cyclin-dependent kinase (CDK) inhibitors to influence cell proliferation. It also participates in growth hormone (GH) mediated cell multiplication, but does not induce tumors. The expression of Foxm1b has been observed in many tumor cell lines and malignant tumors, indicating that it might be an essential proto-oncogene in carcinogenesis. Furthermore, Foxm1b may take part in liver regeneration after hepatectomy, hepatic failure and liver transplantation. Foxm1b is a new potential target for the treatment human hepatic cell carcinoma (HCC).
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PMID:[Significance of Forkhead Box m1b (Foxm1b) gene in cell proliferation and carcinogenesis]. 1871 Jun 29