Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0016632 (Fox)
 1,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An observer views a long (1-2 sec) monocular stimulus. Following stimulus offset there is a dark interstimulus interval (ISI). After the ISI, brief test flashes are presented to both eyes simultaneously. For ISIs less than 100-200 msec, only the test flash contralateral to the stimulated eye is seen. The test flash in the ipsilateral eye is not seen. For ISIs of 200-1000 msec, the contralateral test flash is seen more clearly and completely than the ipsilateral flash (Experiments 1 and 2). The initial and ipsilateral test flash need not be spatially similar. The initial stimulus can be dim but must be longer than 150 msec (Experiment 3). Experiment 3 precludes forward masking or light adaptation as explanation. The effect is relatively independent of the length of the test flash (Experiment 4). The results can be explained in terms of the known properties of binocular rivalry and reinforce the hypothesis (Fox and Check, 1968) that rivalry acts nonselectively, independent of factors such as spatial frequency, luminance, or orientation.
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PMID:Reversing ocular dominance and suppression in a single flash. 674 Sep 66

The National Cancer Institute (NCI), in its goal to reduce cancer mortality by 50% by the year 2000, has placed a special emphasis on prevention and early detection, especially in underserved populations. Check-Up On Health is a community based health education program being carried out by Fox Chase Cancer Center in three inner city Philadelphia neighborhoods, to improve the provision of appropriate cancer screening and prevention services to older, blue-collar adults by their primary care physicians. Primary care physicians in the chosen neighborhoods were targeted to receive a brief cancer prevention educational message delivered by project staff and patterned on the model of drug detailing developed by the pharmaceutical industry. This study represents an attempt to evaluate the feasibility and acceptability of such an approach aimed at improving cancer prevention promotion in the health care system. Primary care physicians were identified by community residents who attended one of 67 Check-Up On Health education presentations about cancer prevention at churches, social clubs, and senior-citizen centers within the targeted neighborhoods. An attempt was then made by project staff to visit each identified physician in his/her office or clinic, during office hours, both to conduct a brief survey and to deliver an educational message about either cancer screening guidelines or counseling for smoking cessation. The physicians were also provided with educational materials for themselves as well as their patients. Twelve months after the visit, a follow-up phone call to the physicians assessed the impact of the visit and solicited suggestions for future outreach efforts.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Academic detailing: a model for in-office CME. 818 79

The prevalence of dementia in the UK is rising rapidly and is predicted to double over the next 30 years. The NHS in England has been told to push for a rapid rise in dementia diagnosis rates, so that by 2015, two out of three cases are identified. The Prime Minister has raised the 'dementia challenge' as a priority for the NHS. While there is agreement on the need for action, debate arises over the nature of that intervention. Some, including Professor Alessi, argue that tools exist to support the diagnosis of mild cognitive impairment and they should be used because the disease is amenable to interventions. He believes that we need a shift in knowledge and attitude from thresholds to a continuum of cognitive impairment, from late to early stages and from effects to causes. The Montreal Cognitive Assessment (MoCa) should become part of the routine NHS Health Check after people reach age 40. Dr Fox argues on the other hand that widespread testing could lead to unnecessary anxiety and panic among those at risk and that funding should be focused on learning more about the early stages of dementia. While the concept of early testing is appealing, there is a large knowledge gap; instruments in use have not been tested in pre-dementia patients and have limited validity. While there is debate over the approach, we can agree that the economic and social impacts of this condition need to be addressed sooner rather than later.
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PMID:The use of wide-scale mental agility testing to identify people at risk of dementia: crucial or harmful? 2499 45