Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0016632 (Fox)
 1,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A review of cutaneous reactions associated with oral contraceptives intended to help the practitioner is presented. The skin responses to gestagens depend upon the sensitivity of the patient, the nature of the gestagen, and the ratio of progestogen to estrogen. Reactions are classified according to their physiologic mechanisms: hormonal effects, immune response, altered porphyrin metabolism, and miscellaneous skin problems. Some of the reactions associated with pseudopregnancy include herpes gestationis, melasma, vaginal candidiasis, cholestatic jaundice, alopecia, and possibly hypertophic gingivitis, neurofibromatosis, and telangiectasia. Hormonal effects include acneform eruptions, diffuse hair loss, and decrease of sebum production. Adverse effects exerted via the immune system include: candidiasis, decreased delayed skin-test reactivity, increased viral infections, flare of lupus erthematosus, erythema nodosum, erythema multiforme, photodermatitis, and herpes gestationis. Altered porphyrin metabolism effects include induction of porphyria and of variegate porphyria. Beneficial effects of oral contraceptives include improvement of acne, lessening of premenstrual flaring of aphthous ulcers, and improvement of Fox-Fordyce disease with estrogenic preparations. There is an unclear association between seborrhea, epithelial inclusion cysts, and hidradenitis supporativa and contraceptive therapy.
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PMID:Desirable and undesirable cutaneous effects of oral contraceptives. 1222 28

Melasma, moniliasis, photosensitivity, alopecia, and bullous eruptions are the most frequently reported dermatological side-effects of oral contraceptives. Other conditions reported occasionally as resulting from or being aggravated by these drugs have been acne, hidradenitis suppurativa, seborrhea, and Fox-Fordyce disease. Very rarely erythema nodosum, purpura, lupus erythematosus, increase in number of moles, and hypertrophic gingivitis have been associated. Melasma occurs within months or after a year in most cases, and may pass off gradually after stopping the drug. A malnutrition factor has been suggested and vitamin-B used as therapy. Photosensitivity may be a factor in melasma or occur independently. A period of months is required for the development of moniliasis. Family planning centers with their large numbers of patients should be a help in solving these problems but other specialists are needed also.
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PMID:Oral contraceptive and dermatology. 1230 10

We report a case of a healthy 26-year-old male with multiple asymptomatic reddish papules and papule-nodules on the central area of the face, persisting from more than 2 months and gradually increasing in number. An incisional skin biopsy revealed a confluent dense granulomatous infiltrate centred by large areas of eosinophilic necrosis consistent with the diagnosis of lupus miliaris disseminatus faciei (LMDF). This is a rare dermatosis first described in 1878 by Fox, that often poses a clinical challenge as it is a disease process which is difficult to diagnose. In fact, in our case, a diagnosis of LMDF was made on skin biopsy. We think that collaboration among dermatologists and General Practitioners is very important for diagnosis of rare dermatosis and especially for management of it, in order to prevent the development of depressed scars.
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PMID:Lupus miliaris disseminatus faciei in a young male. 2634 25