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Query: UMLS:C0016632 (Fox)
 1,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Many of the problems associated with the clinical application of event-related potentials (ERPs) are well recognized. These include the broad inter-subject variability of peak latencies and amplitudes in control groups, as well as the apparent non-specificity of some ERP tests. In addition, it is often the case that the same test yields a different proportion of 'hits' (in terms of identification of abnormality in patients classified by other means as having dementia) when used by different research groups. This is almost certainly due to differences in the disease state of the patients being tested. The difference between hit rates identifies another important factor which is not often considered in the application of ERP tests in clinical medicine. This is that although an ERP test may identify abnormality in the later stages of disease, the true task for the test is to identify abnormality in early disease when evidence of cognitive dysfunction will be different and less frank than in later stages of the disorder. It is therefore, necessary to identify the cognitive deficits associated with the early stages of dementia and devise appropriate ERP tests to detect these deficits. A recent paper by Fox et al. (Fox, N.C., Warrington, E.K., Seiffer, A.L., Agnew, S.K., Rossor, M.N., 1998. Presymptomatic cognitive deficits in individuals at risk of familial Alzheimer's disease. A longitudinal prospective study. Brain 121, 1631-1639.) suggests that ERP tests of verbal memory function may be the most sensitive for detecting the early stages of Alzheimer's disease.
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PMID:Clinical application of event-related potentials in dementing illness: issues and problems. 1082 74

Fox, Greiffenstein, and Lees-Haley (2005) and McCaffrey and Yantz (2005) criticized our 2004 article that reported neuropsychological evidence of cognitive impairment in a sample of individuals exposed to toxic molds who complained of cognitive difficulties (Gordon et al., 2004). They critiqued the study's justification, design, analyses, and conclusions and characterized it as poor epidemiology. This article is a rebuttal to their comments. It documents that both sets of negative comments are based on frequent inaccuracies, mischaracterizations of our findings, and red herrings. Furthermore, they failed to refute the implications of the study's main findings.
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PMID:Cognitive impairment associated with toxigenic fungal exposure: a response to two critiques. 1613 39

The prevalence of dementia in the UK is rising rapidly and is predicted to double over the next 30 years. The NHS in England has been told to push for a rapid rise in dementia diagnosis rates, so that by 2015, two out of three cases are identified. The Prime Minister has raised the 'dementia challenge' as a priority for the NHS. While there is agreement on the need for action, debate arises over the nature of that intervention. Some, including Professor Alessi, argue that tools exist to support the diagnosis of mild cognitive impairment and they should be used because the disease is amenable to interventions. He believes that we need a shift in knowledge and attitude from thresholds to a continuum of cognitive impairment, from late to early stages and from effects to causes. The Montreal Cognitive Assessment (MoCa) should become part of the routine NHS Health Check after people reach age 40. Dr Fox argues on the other hand that widespread testing could lead to unnecessary anxiety and panic among those at risk and that funding should be focused on learning more about the early stages of dementia. While the concept of early testing is appealing, there is a large knowledge gap; instruments in use have not been tested in pre-dementia patients and have limited validity. While there is debate over the approach, we can agree that the economic and social impacts of this condition need to be addressed sooner rather than later.
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PMID:The use of wide-scale mental agility testing to identify people at risk of dementia: crucial or harmful? 2499 45

Older adults are the largest consumer of cable news, which includes negative and politicized content and may constitute a daily stressor. As older adults are also vulnerable to the negative consequences of stress, we hypothesized that cable news watching could induce a stress reaction and impair cognitive function. We tested exposures to cable news (i.e., Fox News and MSNBC) in a within-subject randomized controlled design in 34 healthy older adults. We also included negative (Public Broadcasting Station) and positive (trier social stress test) controls. Cable news watching had no effect on psychological stress, physiological stress, or cognitive function. This remained true even if the news exposures were discordant with participants' political affiliation. We conclude that brief cable news watching does not induce a physiological or subjective stress response or cognitive impairment among healthy older adults.
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PMID:Effects of Cable News Watching on Older Adults' Physiological and Self-Reported Stress and Cognitive Function. 2913 20