Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0016632 (
Fox
)
1,461
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Although mixtures of
HES
and sugars are used to preserve cells during freezing or drying, little is known about the glass transition of
HES
, or how mixtures of
HES
and sugars vitrify. These difficulties may be due to the polydispersity between
HES
samples or differences in preparation techniques, as well as problems in measuring the glass transition temperature (T(g)) using differential scanning calorimetry (DSC). In this report, we examine the T(g) of mixtures of
HES
and trehalose sugar with <1% moisture content using DSC measurements. By extrapolating these measurements to pure
HES
using the Gordon-Taylor and
Fox
equations, we were able to estimate the T(g) of our
HES
sample at 44 degrees C. These results were additionally confirmed by using mixtures of glucose-
HES
which yielded a similar extrapolated T(g) value. Our approach to estimating the glass transition temperature of
HES
may be useful in other cases where glass transitions are not easily identified.
...
PMID:The glass transition temperature of mixtures of trehalose and hydroxyethyl starch. 1223 95
