Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0016632 (Fox)
 1,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Variation in the percentage of lambs seroconverting to bluetongue viruses was seen between sites and years in Barbados. Transmission at some sites was nearly absent whereas all lambs at one site became seropositive. The agar gel immunodiffusion test for bluetongue gave consistent results in series of serum samples from 112 of 121 sentinel lambs. Collections of biting midges in association with sheep yielded six species: Culicoides insignis Lutz, C. pusillus Lutz, C. phlebotomus (Williston), C. furens (Poey), C. jamaicensis Edwards and C. trilineatus Fox. The first two species comprised 92% of those caught during a sentinel lamb study and were the predominant species trapped for virus isolation. No viruses were recovered from 5517 C. insignis, 614 C. pusillus, three C. trilineatus and two C. furens placed into pools during two brief intensive trapping operations.
 ...
PMID:Bluetongue epidemiology in the Caribbean region: serological and entomological evidence from a pilot study in Barbados. 196 78

Potential biting midge vectors were collected at two sites on St. Croix as part of an ongoing study on the epidemiology of bluetongue viruses in the Caribbean region. Six species of Culicoides were trapped in a New Jersey light trap (mean = 173 biting midges/trap night) near cattle on a dairy farm. C. furens (Poey) and C. insignis Lutz were the predominant phototactic species, and C. pusillus Lutz, C. trilineatus Fox, C. jamaicensis Edwards, and C. phlebotomus (Williston) were collected less frequently. Four species of Culicoides were aspirated from bovine bait during the morning and evening crepuscular periods with a modified car vacuum. C. furens was aspirated primarily from the ventral portions of the bovine host, whereas C. insignis and C. pusillus were collected principally from the dorsum, and C. trilineatus was collected equally from all aspects. At least one individual of each of these aspirated species was blood engorged. Because C. furens, C. insignis, C. pusillus, and C. trilineatus were most abundant and feed on cattle, they deserve further consideration as vectors of bluetongue virus on St. Croix.
 ...
PMID:Culicoides spp. (Diptera: Ceratopogonidae) associated with cattle in St. Croix, Virgin Islands, and their relevance to bluetongue virus. 217 91

In 1982, we advanced a phylogeny that attributed eight alleles of the phosphoglucomutase 1 locus (PGM1) to three independent mutations in a primal allele, followed by four intragenic recombination events involving these mutants [Takahashi, N., Neel, J. V., Satoh, C., Nishizaki, J. & Masunari, N. (1982) Proc. Natl. Acad. Sci. USA 79, 6636-6640]. The recent description of a cDNA probe for this locus [Whitehouse, D. B., Putt, W., Lovegrove, J. U., Morrison, K., Hollyoake, M., Fox, M. F., Hopkinson, D. A. & Edwards, Y. H. (1992) Proc. Natl. Acad. Sci. USA 89, 411-415] now renders it possible to test the validity of this phylogeny. cDNAs of PGM1 reverse-transcribed from mRNAs obtained from Japanese individuals possessing eight different electrophoretically defined alleles (PGM1*1+, PGM1*1-, PGM1*2+, PGM1*2-, PGM1*3+, PGM1*3-, PGM1*7+, PGM1*7-) were amplified by PCR and the sequences were determined. Only three different base substitutions were identified when PGM1*1+ was taken as the reference allele, as follows: an A to T transversion at residue 265, a C to T transition at residue 723, and a T to C transition at residue 1320. The second of these substitutions creates a Bgl II restriction enzyme site and the third creates a Nla III site. At the amino acid level, these substitutions alter amino acid 67 from Lys to Met, amino acid 220 from Arg to Cys, and amino acid 419 from Tyr to His, respectively. These mutations resulted in the electrophoretic properties defining PGM1*7+, the PGM1*2+, and the PGM1*1- alleles, respectively. Subsequent intragenic recombinational events resulted in the remaining four alleles. For two of these latter alleles (PGM1*7- and PGM1*3-), more than one type of intragenic crossover can produce the allele. These findings verify the predicted phylogeny and provide a case study in the evolution of complexity at a genetic locus.
 ...
PMID:Intragenic recombination at the human phosphoglucomutase 1 locus: predictions fulfilled. 790 67

Dr. Ida Lystic completed her MD degree at the prestigious Harvey Medical School (which has since been renamed the Harvey Provider School) and her residency in internal medicine and gastroenterology fellowship at the OTHER (Owen T. Henry and Eugene Rutherford) Medical Center. She was subsequently hired as an assistant professor at the BEST (Byron Edwards and Samuel Thompson) Medical Center in 2015. After eventually completing an extensive list of employment requirements, she was able to begin seeing patients. She had not anticipated a change in the electronic medical record systems-from the user-friendly intuitive SIMPLE (Succinct Input Making Patients' Lives Electronic) system to the complicated and challenging LEGEND (perhaps, as her colleagues had suggested, Lengthy and Excessively Graded Evaluation and Nomenclature for Diagnosis) system. Nor had she expected some of the challenges encountered in her daily clinic routine: The lack of schedulers for her patients (based on recommendations by the Optima Efficiency Consultant Group and incorporated by the BEST efficiency department) and the addition of egg timers on the doors along with a compliance spreadsheet and corrective action plan for the tardy physicians to complete to encourage punctuality (based on the assessment of the Wait Time Committee). She joined the LOST (Laboratory OverSight and Testing) Committee, because participation to support BEST Medical Center practices is strongly suggested for faculty seeking promotion; however, when the new committee chairman-who is a surgeon-was elected, the noon meetings were rescheduled for 6:00 am each month. At the request of her recently divorced department chairman, the philandering Dr. Seymore Fox, she became deputy head of the Gastroenterology Fellowship Selection Committee; she recently coordinated the selection of the physicians for next year's fellowship. The fellowship candidate selection process at the BEST Medical School is probably similar to that performed at the OTHER Medical Center; however, innovative interview techniques-such as assessment for manual dexterity (with the "space race") and typing skills-have been incorporated to enhance the selection of the best candidates. Dr. Ida Lystic, the gastroenterology department, and the medical school at "the BEST Medical Center" are creations of the author's imagination; yet, many of the anecdotes are based on actual events whose details have been modified to protect the guilty.
 ...
PMID:Fellowship candidate selection at the BEST Medical Center: A novel process. 2891 30