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Query: UMLS:C0016632 (Fox)
 1,461 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In spite of remarkable therapeutic results obtained by gestagens with antiandrogenic activity, usually combined with estrogen, in oily seborrhea, acne, Fox-Fordyce disease, androgenetic alopecia and hirsutism many dermatologist still hesitate to treat the named disorders by hormones. The reason for their hesitation appears to be the erroneous belief, that the named disturbances represent hormonal disorders the treatment of which does not belong to dermatology. After a survey on the mechanism of action of antiandrogens the basic difference between androgen dependent skin disorders and endocrinopathies with manifestation on the skin and its appendages is explained. Androgen dependent skin disorders, like oily seborrhea and most cases of acne are not the result of endocrine disturbances in the sense of an pathologically increased or decreased production of sexual hormons. Administering sexual hormons the physician takes advantage of the sebosuppressive effect of female sexual hormons as he does of the antiallergic activity of the hormon cortisol (and related compounds) in the treatment of eczemas. The antiandrogenic treatment of androgenetic alopecia, hirsutism and androgenetic acne--with their underlying hormonal disturbance, consisting in an increased production of androgens, represents an quasi etiological therapy. As in these cases the hormonal disturbances finds its expression mainly or exclusively in disorders of the skin or hair growth, the dermatologist, preferentially in cooperation with endocrinogists and/or gynacologists remains entitled to take over the treatment. The available drugs are discussed and suggestions are made for their appropriate use.
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PMID:[Dermatologic indications for anti-androgenic treatment]. 8 9

A review of cutaneous reactions associated with oral contraceptives intended to help the practitioner is presented. The skin responses to gestagens depend upon the sensitivity of the patient, the nature of the gestagen, and the ratio of progestogen to estrogen. Reactions are classified according to their physiologic mechanisms: hormonal effects, immune response, altered porphyrin metabolism, and miscellaneous skin problems. Some of the reactions associated with pseudopregnancy include herpes gestationis, melasma, vaginal candidiasis, cholestatic jaundice, alopecia, and possibly hypertophic gingivitis, neurofibromatosis, and telangiectasia. Hormonal effects include acneform eruptions, diffuse hair loss, and decrease of sebum production. Adverse effects exerted via the immune system include: candidiasis, decreased delayed skin-test reactivity, increased viral infections, flare of lupus erthematosus, erythema nodosum, erythema multiforme, photodermatitis, and herpes gestationis. Altered porphyrin metabolism effects include induction of porphyria and of variegate porphyria. Beneficial effects of oral contraceptives include improvement of acne, lessening of premenstrual flaring of aphthous ulcers, and improvement of Fox-Fordyce disease with estrogenic preparations. There is an unclear association between seborrhea, epithelial inclusion cysts, and hidradenitis supporativa and contraceptive therapy.
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PMID:Desirable and undesirable cutaneous effects of oral contraceptives. 1222 28

Melasma, moniliasis, photosensitivity, alopecia, and bullous eruptions are the most frequently reported dermatological side-effects of oral contraceptives. Other conditions reported occasionally as resulting from or being aggravated by these drugs have been acne, hidradenitis suppurativa, seborrhea, and Fox-Fordyce disease. Very rarely erythema nodosum, purpura, lupus erythematosus, increase in number of moles, and hypertrophic gingivitis have been associated. Melasma occurs within months or after a year in most cases, and may pass off gradually after stopping the drug. A malnutrition factor has been suggested and vitamin-B used as therapy. Photosensitivity may be a factor in melasma or occur independently. A period of months is required for the development of moniliasis. Family planning centers with their large numbers of patients should be a help in solving these problems but other specialists are needed also.
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PMID:Oral contraceptive and dermatology. 1230 10

Recently a group of hormonal contraceptives, used in the treatment of skin diseases, has been taken off the market, leading dermatologists to critically evaluate sex hormone (SH) therapy. The antiandrogenic side effect of hormonal contraceptives has been effective in treating hormonally induced skin disorders, e.g., involving oil or endocrine secretion, and hair growth. SH therapy is indicated for treatment of female acne (reports of 70% success after 2-6 months' intensive therapy), and in some cases male acne, and also for seborrhoea (report of 90% success after 1-3 months' intensive treatment), also for female sebocystamatose and Fox-Fordyce disease. In the case of female androgenic alopecia and hirsutism, SH therapy results are limited. Rosacea and periole dermatitis should probably not be treated with SH therapy. Patients with skin disorders should carefully avoid any androgen-effective oral contraceptives, even for birth control purposes, and pay particular attention to the progesterone content, since some progesterones have androgenic aftereffects (testosterone anabolica, nortestosterone derivatives). The 2-phased Eunomin with chlormadinone is 1 recommended hormonal antiandrogenic preparation available at the present time. If 1-phase therapy is preferable, Menova may be used. Since remissions of psoriasis have been observed in pregnancy, SH therapy with nortestosterone may be indicated; and also in the case of herpes simplex menstrualis and perigo simplex subacuta, therapy should be attempted.
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PMID:[Systematic treatment with sex hormones in dermatology]. 1230 25